Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KDM7A (lysine demethylase 7A)

Identity

Alias_namesJHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
lysine (K)-specific demethylase 7A
Alias_symbol (synonym)KIAA1718
Other alias
HGNC (Hugo) KDM7A
LocusID (NCBI) 80853
Atlas_Id 52632
Location 7q34  [Link to chromosome band 7q34]
Location_base_pair Starts at 139784546 and ends at 139876741 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ERBB2 (17q12) / KDM7A (7q34)KDM7A (7q34) / BRAF (7q34)KDM7A (7q34) / NDUFB2 (7q34)
KDM7A (7q34) / SND1 (7q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KDM7A   22224
Cards
Entrez_Gene (NCBI)KDM7A  80853  lysine demethylase 7A
AliasesJHDM1D
GeneCards (Weizmann)KDM7A
Ensembl hg19 (Hinxton)ENSG00000006459 [Gene_View]  chr7:139784546-139876741 [Contig_View]  KDM7A [Vega]
Ensembl hg38 (Hinxton)ENSG00000006459 [Gene_View]  chr7:139784546-139876741 [Contig_View]  KDM7A [Vega]
ICGC DataPortalENSG00000006459
TCGA cBioPortalKDM7A
AceView (NCBI)KDM7A
Genatlas (Paris)KDM7A
WikiGenes80853
SOURCE (Princeton)KDM7A
Genetics Home Reference (NIH)KDM7A
Genomic and cartography
GoldenPath hg19 (UCSC)KDM7A  -     chr7:139784546-139876741 -  7q34   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KDM7A  -     7q34   [Description]    (hg38-Dec_2013)
EnsemblKDM7A - 7q34 [CytoView hg19]  KDM7A - 7q34 [CytoView hg38]
Mapping of homologs : NCBIKDM7A [Mapview hg19]  KDM7A [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB051505 AK057208 AK131497 BC127007 BX641017
RefSeq transcript (Entrez)NM_030647
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929333
Consensus coding sequences : CCDS (NCBI)KDM7A
Cluster EST : UnigeneHs.308710 [ NCBI ]
CGAP (NCI)Hs.308710
Alternative Splicing GalleryENSG00000006459
Gene ExpressionKDM7A [ NCBI-GEO ]   KDM7A [ EBI - ARRAY_EXPRESS ]   KDM7A [ SEEK ]   KDM7A [ MEM ]
Gene Expression Viewer (FireBrowse)KDM7A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80853
GTEX Portal (Tissue expression)KDM7A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZMT4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZMT4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZMT4
Splice isoforms : SwissVarQ6ZMT4
Catalytic activity : Enzyme1.14.11.- [ Enzyme-Expasy ]   1.14.11.-1.14.11.- [ IntEnz-EBI ]   1.14.11.- [ BRENDA ]   1.14.11.- [ KEGG ]   
PhosPhoSitePlusQ6ZMT4
Domaine pattern : Prosite (Expaxy)JMJC (PS51184)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)   
Domains : Interpro (EBI)JmjC_dom    Zinc_finger_PHD-type_CS    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)JmjC (PF02373)    PHD (PF00628)   
Domain families : Pfam (NCBI)pfam02373    pfam00628   
Domain families : Smart (EMBL)JmjC (SM00558)  PHD (SM00249)  
Conserved Domain (NCBI)KDM7A
DMDM Disease mutations80853
Blocks (Seattle)KDM7A
PDB (SRS)3KV5    3KV6    3KV9    3KVA    3KVB    3U78   
PDB (PDBSum)3KV5    3KV6    3KV9    3KVA    3KVB    3U78   
PDB (IMB)3KV5    3KV6    3KV9    3KVA    3KVB    3U78   
PDB (RSDB)3KV5    3KV6    3KV9    3KVA    3KVB    3U78   
Structural Biology KnowledgeBase3KV5    3KV6    3KV9    3KVA    3KVB    3U78   
SCOP (Structural Classification of Proteins)3KV5    3KV6    3KV9    3KVA    3KVB    3U78   
CATH (Classification of proteins structures)3KV5    3KV6    3KV9    3KVA    3KVB    3U78   
SuperfamilyQ6ZMT4
Human Protein AtlasENSG00000006459
Peptide AtlasQ6ZMT4
IPIIPI00418567   IPI00738581   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZMT4
IntAct (EBI)Q6ZMT4
FunCoupENSG00000006459
BioGRIDKDM7A
STRING (EMBL)KDM7A
ZODIACKDM7A
Ontologies - Pathways
QuickGOQ6ZMT4
Ontology : AmiGOiron ion binding  iron ion binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  transcription, DNA-templated  zinc ion binding  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors  midbrain development  histone demethylase activity  histone demethylase activity (H3-K9 specific)  histone H3-K9 demethylation  methylated histone binding  histone H4-K20 demethylation  histone demethylase activity (H4-K20 specific)  positive regulation of transcription, DNA-templated  histone demethylase activity (H3-K36 specific)  oxidation-reduction process  histone H3-K36 demethylation  histone H3-K27 demethylation  histone demethylase activity (H3-K27 specific)  
Ontology : EGO-EBIiron ion binding  iron ion binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  transcription, DNA-templated  zinc ion binding  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors  midbrain development  histone demethylase activity  histone demethylase activity (H3-K9 specific)  histone H3-K9 demethylation  methylated histone binding  histone H4-K20 demethylation  histone demethylase activity (H4-K20 specific)  positive regulation of transcription, DNA-templated  histone demethylase activity (H3-K36 specific)  oxidation-reduction process  histone H3-K36 demethylation  histone H3-K27 demethylation  histone demethylase activity (H3-K27 specific)  
NDEx NetworkKDM7A
Atlas of Cancer Signalling NetworkKDM7A
Wikipedia pathwaysKDM7A
Orthology - Evolution
OrthoDB80853
GeneTree (enSembl)ENSG00000006459
Phylogenetic Trees/Animal Genes : TreeFamKDM7A
HOVERGENQ6ZMT4
HOGENOMQ6ZMT4
Homologs : HomoloGeneKDM7A
Homology/Alignments : Family Browser (UCSC)KDM7A
Gene fusions - Rearrangements
Fusion : MitelmanKDM7A/SND1 [7q34/7q32.1]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKDM7A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KDM7A
dbVarKDM7A
ClinVarKDM7A
1000_GenomesKDM7A 
Exome Variant ServerKDM7A
ExAC (Exome Aggregation Consortium)KDM7A (select the gene name)
Genetic variants : HAPMAP80853
Genomic Variants (DGV)KDM7A [DGVbeta]
DECIPHER (Syndromes)7:139784546-139876741  ENSG00000006459
CONAN: Copy Number AnalysisKDM7A 
Mutations
ICGC Data PortalKDM7A 
TCGA Data PortalKDM7A 
Broad Tumor PortalKDM7A
OASIS PortalKDM7A [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDKDM7A
BioMutasearch KDM7A
DgiDB (Drug Gene Interaction Database)KDM7A
DoCM (Curated mutations)KDM7A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KDM7A (select a term)
intoGenKDM7A
Cancer3DKDM7A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenKDM7A
Genetic Testing Registry KDM7A
NextProtQ6ZMT4 [Medical]
TSGene80853
GENETestsKDM7A
Huge Navigator KDM7A [HugePedia]
snp3D : Map Gene to Disease80853
BioCentury BCIQKDM7A
ClinGenKDM7A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80853
Chemical/Pharm GKB GenePA162392512
Clinical trialKDM7A
Miscellaneous
canSAR (ICR)KDM7A (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKDM7A
EVEXKDM7A
GoPubMedKDM7A
iHOPKDM7A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:06:03 CEST 2017

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