KHSRP (KH-type splicing regulatory protein)

2007-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
FBP2,FUBP2,KSRP,p75
FUSION GENES

Other Information

Locus ID:

NCBI: 8570
MIM: 603445
HGNC: 6316
Ensembl: ENSG00000088247

Variants:

dbSNP: 8570
ClinVar: 8570
TCGA: ENSG00000088247
COSMIC: KHSRP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088247ENST00000398148Q92945
ENSG00000088247ENST00000594496M0R263
ENSG00000088247ENST00000594745M0QYG1
ENSG00000088247ENST00000595223M0R3J3
ENSG00000088247ENST00000595258M0QXW7
ENSG00000088247ENST00000595548M0QYH3
ENSG00000088247ENST00000597656M0R251
ENSG00000088247ENST00000599395M0R0I5
ENSG00000088247ENST00000600480M0R0C6
ENSG00000088247ENST00000619396A0A087WTP3

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994
Gene ExpressionREACTOMER-HSA-74160
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
KSRP (KHSRP) binds and destabilizes mRNAREACTOMER-HSA-450604

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194586192009The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.284
151751532004A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.173
206398842010Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis.128
179087892007Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets.72
166484662006Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay.49
146572382004Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA.43
155149712005IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR.41
191985872009Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding.40
195856522009Overexpression of far upstream element binding proteins: a mechanism regulating proliferation and migration in liver cancer cells.39
211962642011KSRP, many functions for a single protein.30

Citation

Dessen P

KHSRP (KH-type splicing regulatory protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45774/khsrp