KIF15 (kinesin family member 15)

2016-10-01  

Identity

HGNC
KIF15
LOCATION
3p21.31
LOCUSID
56992
ALIAS
HKLP2,KLP2,KNSL7,NY-BR-62
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56992
MIM: 617569
HGNC: 17273
Ensembl: ENSG00000163808

Variants:

dbSNP: 56992
ClinVar: 56992
TCGA: ENSG00000163808
COSMIC: KIF15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163808ENST00000326047Q9NS87
ENSG00000163808ENST00000422209H7BZT2
ENSG00000163808ENST00000425755C9JKA9
ENSG00000163808ENST00000438321F8WC33
ENSG00000163808ENST00000453693H7C1K7
ENSG00000163808ENST00000481166D6RCT7

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198186182009Kif15 cooperates with eg5 to promote bipolar spindle assembly.107
198186192009The role of Hklp2 in the stabilization and maintenance of spindle bipolarity.61
237917272013Kinesin-12 differentially affects spindle assembly depending on its microtubule substrate.38
270914502016Kinesin-5 inhibitor resistance is driven by kinesin-12.31
246681682014The Kinesin-12 Kif15 is a processive track-switching tetramer.28
251271422014Balanced activity of three mitotic motors is required for bipolar spindle assembly and chromosome segregation.26
285952602017KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway.23
269697272016Kinesin-12 motors cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles.21
220249252011Modulated microtubule dynamics enable Hklp2/Kif15 to assemble bipolar spindles.19
244193852014The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal development.12

Citation

Dessen P

KIF15 (kinesin family member 15)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56576/kif15