KIF18A (kinesin family member 18A)

2010-10-01  

Identity

HGNC
LOCATION
11p14.1
LOCUSID
ALIAS
MS-KIF18A,PPP1R99
FUSION GENES

Other Information

Locus ID:

NCBI: 81930
MIM: 611271
HGNC: 29441
Ensembl: ENSG00000121621

Variants:

dbSNP: 81930
ClinVar: 81930
TCGA: ENSG00000121621
COSMIC: KIF18A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121621ENST00000263181Q8NI77

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383727482024KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.2
384463082024Kinesin Family Member-18A (KIF18A) Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma.0
383727482024KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.2
384463082024Kinesin Family Member-18A (KIF18A) Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma.0
327166402022Knockdown of Circ_CCNB2 Sensitizes Prostate Cancer to Radiation Through Repressing Autophagy by the miR-30b-5p/KIF18A Axis.19
359264612022Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.7
327166402022Knockdown of Circ_CCNB2 Sensitizes Prostate Cancer to Radiation Through Repressing Autophagy by the miR-30b-5p/KIF18A Axis.19
359264612022Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.7
336192542021Chromosomally unstable tumor cells specifically require KIF18A for proliferation.49
338729882021KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.18
336192542021Chromosomally unstable tumor cells specifically require KIF18A for proliferation.49
338729882021KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.18
316771272020Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells.4
319779172020Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.0
320942632020Kinesin KIF18A is a novel PUM-regulated target promoting mitotic progression and survival of a human male germ cell line.4

Citation

Dessen P

KIF18A (kinesin family member 18A)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51714/kif18a