Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KIF2C (kinesin family member 2C)

Identity

Alias (NCBI)CT139
KNSL6
MCAK
HGNC (Hugo) KIF2C
HGNC Alias symbMCAK
CT139
HGNC Previous nameKNSL6
HGNC Previous namekinesin-like 6 (mitotic centromere-associated kinesin)
LocusID (NCBI) 11004
Atlas_Id 41069
Location 1p34.1  [Link to chromosome band 1p34]
Location_base_pair Starts at 44739837 and ends at 44767766 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KIF2C (1p34.1)::CHTF8 (16q22.1)KIF2C (1p34.1)::LYPD6B (2q23.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KIF2C   6393
Cards
Entrez_Gene (NCBI)KIF2C    kinesin family member 2C
AliasesCT139; KNSL6; MCAK
GeneCards (Weizmann)KIF2C
Ensembl hg19 (Hinxton)ENSG00000142945 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142945 [Gene_View]  ENSG00000142945 [Sequence]  chr1:44739837-44767766 [Contig_View]  KIF2C [Vega]
ICGC DataPortalENSG00000142945
TCGA cBioPortalKIF2C
AceView (NCBI)KIF2C
Genatlas (Paris)KIF2C
SOURCE (Princeton)KIF2C
Genetics Home Reference (NIH)KIF2C
Genomic and cartography
GoldenPath hg38 (UCSC)KIF2C  -     chr1:44739837-44767766 +  1p34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KIF2C  -     1p34.1   [Description]    (hg19-Feb_2009)
GoldenPathKIF2C - 1p34.1 [CytoView hg19]  KIF2C - 1p34.1 [CytoView hg38]
ImmunoBaseENSG00000142945
Genome Data Viewer NCBIKIF2C [Mapview hg19]  
OMIM604538   
Gene and transcription
Genbank (Entrez)AB264115 AK290688 AK300756 AK302267 AK312606
RefSeq transcript (Entrez)NM_001297655 NM_001297656 NM_001297657 NM_006845
Consensus coding sequences : CCDS (NCBI)KIF2C
Gene ExpressionKIF2C [ NCBI-GEO ]   KIF2C [ EBI - ARRAY_EXPRESS ]   KIF2C [ SEEK ]   KIF2C [ MEM ]
Gene Expression Viewer (FireBrowse)KIF2C [ Firebrowse - Broad ]
GenevisibleExpression of KIF2C in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11004
GTEX Portal (Tissue expression)KIF2C
Human Protein AtlasENSG00000142945-KIF2C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99661   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99661  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99661
PhosPhoSitePlusQ99661
Domaine pattern : Prosite (Expaxy)KINESIN_MOTOR_1 (PS00411)    KINESIN_MOTOR_2 (PS50067)   
Domains : Interpro (EBI)Kinesin-like_fam    Kinesin_motor_CS    Kinesin_motor_dom    Kinesin_motor_dom_sf    P-loop_NTPase   
Domain families : Pfam (Sanger)Kinesin (PF00225)   
Domain families : Pfam (NCBI)pfam00225   
Domain families : Smart (EMBL)KISc (SM00129)  
Conserved Domain (NCBI)KIF2C
PDB (RSDB)2HEH    4UBF    4Y05    5MIO   
PDB Europe2HEH    4UBF    4Y05    5MIO   
PDB (PDBSum)2HEH    4UBF    4Y05    5MIO   
PDB (IMB)2HEH    4UBF    4Y05    5MIO   
Structural Biology KnowledgeBase2HEH    4UBF    4Y05    5MIO   
SCOP (Structural Classification of Proteins)2HEH    4UBF    4Y05    5MIO   
CATH (Classification of proteins structures)2HEH    4UBF    4Y05    5MIO   
SuperfamilyQ99661
AlphaFold pdb e-kbQ99661   
Human Protein Atlas [tissue]ENSG00000142945-KIF2C [tissue]
HPRD05172
Protein Interaction databases
DIP (DOE-UCLA)Q99661
IntAct (EBI)Q99661
BioGRIDKIF2C
STRING (EMBL)KIF2C
ZODIACKIF2C
Ontologies - Pathways
QuickGOQ99661
Ontology : AmiGOchromosome, centromeric region  kinetochore  kinetochore  microtubule motor activity  protein binding  ATP binding  nucleus  centrosome  spindle  cytosol  kinesin complex  microtubule  cytoplasmic microtubule  microtubule-based movement  microtubule depolymerization  microtubule depolymerization  microtubule depolymerization  mitotic metaphase plate congression  microtubule binding  microtubule cytoskeleton  membrane  ATP hydrolysis activity  centromeric DNA binding  establishment or maintenance of microtubule cytoskeleton polarity  microtubule plus-end  microtubule plus-end  microtubule plus-end binding  cell division  metaphase plate congression  attachment of mitotic spindle microtubules to kinetochore  regulation of chromosome segregation  
Ontology : EGO-EBIchromosome, centromeric region  kinetochore  kinetochore  microtubule motor activity  protein binding  ATP binding  nucleus  centrosome  spindle  cytosol  kinesin complex  microtubule  cytoplasmic microtubule  microtubule-based movement  microtubule depolymerization  microtubule depolymerization  microtubule depolymerization  mitotic metaphase plate congression  microtubule binding  microtubule cytoskeleton  membrane  ATP hydrolysis activity  centromeric DNA binding  establishment or maintenance of microtubule cytoskeleton polarity  microtubule plus-end  microtubule plus-end  microtubule plus-end binding  cell division  metaphase plate congression  attachment of mitotic spindle microtubules to kinetochore  regulation of chromosome segregation  
NDEx NetworkKIF2C
Atlas of Cancer Signalling NetworkKIF2C
Wikipedia pathwaysKIF2C
Orthology - Evolution
OrthoDB11004
GeneTree (enSembl)ENSG00000142945
Phylogenetic Trees/Animal Genes : TreeFamKIF2C
Homologs : HomoloGeneKIF2C
Homology/Alignments : Family Browser (UCSC)KIF2C
Gene fusions - Rearrangements
Fusion : QuiverKIF2C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKIF2C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KIF2C
dbVarKIF2C
ClinVarKIF2C
MonarchKIF2C
1000_GenomesKIF2C 
Exome Variant ServerKIF2C
GNOMAD BrowserENSG00000142945
Varsome BrowserKIF2C
ACMGKIF2C variants
VarityQ99661
Genomic Variants (DGV)KIF2C [DGVbeta]
DECIPHERKIF2C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKIF2C 
Mutations
ICGC Data PortalKIF2C 
TCGA Data PortalKIF2C 
Broad Tumor PortalKIF2C
OASIS PortalKIF2C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKIF2C  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKIF2C
Mutations and Diseases : HGMDKIF2C
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKIF2C
DgiDB (Drug Gene Interaction Database)KIF2C
DoCM (Curated mutations)KIF2C
CIViC (Clinical Interpretations of Variants in Cancer)KIF2C
Cancer3DKIF2C
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604538   
Orphanet
DisGeNETKIF2C
MedgenKIF2C
Genetic Testing Registry KIF2C
NextProtQ99661 [Medical]
GENETestsKIF2C
Target ValidationKIF2C
Huge Navigator KIF2C [HugePedia]
ClinGenKIF2C
Clinical trials, drugs, therapy
MyCancerGenomeKIF2C
Protein Interactions : CTDKIF2C
Pharm GKB GenePA30182
PharosQ99661
Clinical trialKIF2C
Miscellaneous
canSAR (ICR)KIF2C
HarmonizomeKIF2C
ARCHS4KIF2C
DataMed IndexKIF2C
Probes
Litterature
PubMed152 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKIF2C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:39:48 CET 2022

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