Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KIF2C (kinesin family member 2C)

Identity

Alias_namesKNSL6
kinesin-like 6 (mitotic centromere-associated kinesin)
Alias_symbol (synonym)MCAK
CT139
Other alias
HGNC (Hugo) KIF2C
LocusID (NCBI) 11004
Atlas_Id 41069
Location 1p34.1  [Link to chromosome band 1p34]
Location_base_pair Starts at 45205490 and ends at 45233438 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KIF2C (1p34.1) / CHTF8 (16q22.1)KIF2C (1p34.1) / LYPD6B (2q23.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KIF2C   6393
Cards
Entrez_Gene (NCBI)KIF2C  11004  kinesin family member 2C
AliasesCT139; KNSL6; MCAK
GeneCards (Weizmann)KIF2C
Ensembl hg19 (Hinxton)ENSG00000142945 [Gene_View]  chr1:45205490-45233438 [Contig_View]  KIF2C [Vega]
Ensembl hg38 (Hinxton)ENSG00000142945 [Gene_View]  chr1:45205490-45233438 [Contig_View]  KIF2C [Vega]
ICGC DataPortalENSG00000142945
TCGA cBioPortalKIF2C
AceView (NCBI)KIF2C
Genatlas (Paris)KIF2C
WikiGenes11004
SOURCE (Princeton)KIF2C
Genetics Home Reference (NIH)KIF2C
Genomic and cartography
GoldenPath hg19 (UCSC)KIF2C  -     chr1:45205490-45233438 +  1p34.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KIF2C  -     1p34.1   [Description]    (hg38-Dec_2013)
EnsemblKIF2C - 1p34.1 [CytoView hg19]  KIF2C - 1p34.1 [CytoView hg38]
Mapping of homologs : NCBIKIF2C [Mapview hg19]  KIF2C [Mapview hg38]
OMIM604538   
Gene and transcription
Genbank (Entrez)AB264115 AK290688 AK300756 AK302267 AK312606
RefSeq transcript (Entrez)NM_001297655 NM_001297656 NM_001297657 NM_006845
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)KIF2C
Cluster EST : UnigeneHs.720061 [ NCBI ]
CGAP (NCI)Hs.720061
Alternative Splicing GalleryENSG00000142945
Gene ExpressionKIF2C [ NCBI-GEO ]   KIF2C [ EBI - ARRAY_EXPRESS ]   KIF2C [ SEEK ]   KIF2C [ MEM ]
Gene Expression Viewer (FireBrowse)KIF2C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11004
GTEX Portal (Tissue expression)KIF2C
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99661   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99661  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99661
Splice isoforms : SwissVarQ99661
PhosPhoSitePlusQ99661
Domaine pattern : Prosite (Expaxy)KINESIN_MOTOR_1 (PS00411)    KINESIN_MOTOR_2 (PS50067)   
Domains : Interpro (EBI)Kinesin-like_fam    Kinesin_motor_CS    Kinesin_motor_dom    P-loop_NTPase   
Domain families : Pfam (Sanger)Kinesin (PF00225)   
Domain families : Pfam (NCBI)pfam00225   
Domain families : Smart (EMBL)KISc (SM00129)  
Conserved Domain (NCBI)KIF2C
DMDM Disease mutations11004
Blocks (Seattle)KIF2C
PDB (SRS)2HEH    4UBF    4Y05   
PDB (PDBSum)2HEH    4UBF    4Y05   
PDB (IMB)2HEH    4UBF    4Y05   
PDB (RSDB)2HEH    4UBF    4Y05   
Structural Biology KnowledgeBase2HEH    4UBF    4Y05   
SCOP (Structural Classification of Proteins)2HEH    4UBF    4Y05   
CATH (Classification of proteins structures)2HEH    4UBF    4Y05   
SuperfamilyQ99661
Human Protein AtlasENSG00000142945
Peptide AtlasQ99661
HPRD05172
IPIIPI00290435   IPI00216113   IPI00552801   IPI00942912   IPI00645758   
Protein Interaction databases
DIP (DOE-UCLA)Q99661
IntAct (EBI)Q99661
FunCoupENSG00000142945
BioGRIDKIF2C
STRING (EMBL)KIF2C
ZODIACKIF2C
Ontologies - Pathways
QuickGOQ99661
Ontology : AmiGOchromosome, centromeric region  kinetochore  condensed chromosome kinetochore  microtubule motor activity  protein binding  ATP binding  nucleus  cytosol  kinesin complex  cytoplasmic microtubule  retrograde vesicle-mediated transport, Golgi to ER  microtubule-based movement  microtubule-based movement  microtubule depolymerization  microtubule depolymerization  sister chromatid cohesion  mitotic nuclear division  mitotic metaphase plate congression  metabolic process  cell proliferation  microtubule cytoskeleton  membrane  ATPase activity  centromeric DNA binding  antigen processing and presentation of exogenous peptide antigen via MHC class II  establishment or maintenance of microtubule cytoskeleton polarity  microtubule plus-end  microtubule plus-end binding  cell division  regulation of chromosome segregation  
Ontology : EGO-EBIchromosome, centromeric region  kinetochore  condensed chromosome kinetochore  microtubule motor activity  protein binding  ATP binding  nucleus  cytosol  kinesin complex  cytoplasmic microtubule  retrograde vesicle-mediated transport, Golgi to ER  microtubule-based movement  microtubule-based movement  microtubule depolymerization  microtubule depolymerization  sister chromatid cohesion  mitotic nuclear division  mitotic metaphase plate congression  metabolic process  cell proliferation  microtubule cytoskeleton  membrane  ATPase activity  centromeric DNA binding  antigen processing and presentation of exogenous peptide antigen via MHC class II  establishment or maintenance of microtubule cytoskeleton polarity  microtubule plus-end  microtubule plus-end binding  cell division  regulation of chromosome segregation  
NDEx NetworkKIF2C
Atlas of Cancer Signalling NetworkKIF2C
Wikipedia pathwaysKIF2C
Orthology - Evolution
OrthoDB11004
GeneTree (enSembl)ENSG00000142945
Phylogenetic Trees/Animal Genes : TreeFamKIF2C
HOVERGENQ99661
HOGENOMQ99661
Homologs : HomoloGeneKIF2C
Homology/Alignments : Family Browser (UCSC)KIF2C
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKIF2C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KIF2C
dbVarKIF2C
ClinVarKIF2C
1000_GenomesKIF2C 
Exome Variant ServerKIF2C
ExAC (Exome Aggregation Consortium)KIF2C (select the gene name)
Genetic variants : HAPMAP11004
Genomic Variants (DGV)KIF2C [DGVbeta]
DECIPHER (Syndromes)1:45205490-45233438  ENSG00000142945
CONAN: Copy Number AnalysisKIF2C 
Mutations
ICGC Data PortalKIF2C 
TCGA Data PortalKIF2C 
Broad Tumor PortalKIF2C
OASIS PortalKIF2C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKIF2C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKIF2C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KIF2C
DgiDB (Drug Gene Interaction Database)KIF2C
DoCM (Curated mutations)KIF2C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KIF2C (select a term)
intoGenKIF2C
Cancer3DKIF2C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604538   
Orphanet
MedgenKIF2C
Genetic Testing Registry KIF2C
NextProtQ99661 [Medical]
TSGene11004
GENETestsKIF2C
Huge Navigator KIF2C [HugePedia]
snp3D : Map Gene to Disease11004
BioCentury BCIQKIF2C
ClinGenKIF2C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11004
Chemical/Pharm GKB GenePA30182
Clinical trialKIF2C
Miscellaneous
canSAR (ICR)KIF2C (select the gene name)
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKIF2C
EVEXKIF2C
GoPubMedKIF2C
iHOPKIF2C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:11:54 CET 2017

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