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KIF3A (kinesin family member 3A)

Identity

Alias_symbol (synonym)FLA10
KLP-20
Other alias
HGNC (Hugo) KIF3A
LocusID (NCBI) 11127
Atlas_Id 55104
Location 5q31.1  [Link to chromosome band 5q31]
Location_base_pair Starts at 132692627 and ends at 132737578 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALDOC (17q11.2) / KIF3A (5q31.1)COQ10B (2q33.1) / KIF3A (5q31.1)KIF3A (5q31.1) / FTL (19q13.33)
KIF3A (5q31.1) / RAB2A (8q12.1)LOC220729 (3q29) / KIF3A (5q31.1)NDRG2 (14q11.2) / KIF3A (5q31.1)
ALDOC 17q11.2 / KIF3A 5q31.1NDRG2 14q11.2 / KIF3A 5q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KIF3A   6319
Cards
Entrez_Gene (NCBI)KIF3A  11127  kinesin family member 3A
AliasesFLA10; KLP-20
GeneCards (Weizmann)KIF3A
Ensembl hg19 (Hinxton)ENSG00000131437 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131437 [Gene_View]  chr5:132692627-132737578 [Contig_View]  KIF3A [Vega]
ICGC DataPortalENSG00000131437
TCGA cBioPortalKIF3A
AceView (NCBI)KIF3A
Genatlas (Paris)KIF3A
WikiGenes11127
SOURCE (Princeton)KIF3A
Genetics Home Reference (NIH)KIF3A
Genomic and cartography
GoldenPath hg38 (UCSC)KIF3A  -     chr5:132692627-132737578 -  5q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KIF3A  -     5q31.1   [Description]    (hg19-Feb_2009)
EnsemblKIF3A - 5q31.1 [CytoView hg19]  KIF3A - 5q31.1 [CytoView hg38]
Mapping of homologs : NCBIKIF3A [Mapview hg19]  KIF3A [Mapview hg38]
OMIM604683   
Gene and transcription
Genbank (Entrez)AB209780 AF041853 AK295089 AK313359 AM177178
RefSeq transcript (Entrez)NM_001300791 NM_001300792 NM_007054
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KIF3A
Cluster EST : UnigeneHs.43670 [ NCBI ]
CGAP (NCI)Hs.43670
Alternative Splicing GalleryENSG00000131437
Gene ExpressionKIF3A [ NCBI-GEO ]   KIF3A [ EBI - ARRAY_EXPRESS ]   KIF3A [ SEEK ]   KIF3A [ MEM ]
Gene Expression Viewer (FireBrowse)KIF3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11127
GTEX Portal (Tissue expression)KIF3A
Human Protein AtlasENSG00000131437-KIF3A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y496   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y496  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y496
Splice isoforms : SwissVarQ9Y496
PhosPhoSitePlusQ9Y496
Domaine pattern : Prosite (Expaxy)KINESIN_MOTOR_1 (PS00411)    KINESIN_MOTOR_2 (PS50067)   
Domains : Interpro (EBI)Kinesin_motor_CS    Kinesin_motor_dom    P-loop_NTPase   
Domain families : Pfam (Sanger)Kinesin (PF00225)   
Domain families : Pfam (NCBI)pfam00225   
Domain families : Smart (EMBL)KISc (SM00129)  
Conserved Domain (NCBI)KIF3A
DMDM Disease mutations11127
Blocks (Seattle)KIF3A
SuperfamilyQ9Y496
Human Protein Atlas [tissue]ENSG00000131437-KIF3A [tissue]
Peptide AtlasQ9Y496
HPRD05250
IPIIPI00000455   IPI00929684   IPI00657857   IPI00852815   IPI00867739   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y496
IntAct (EBI)Q9Y496
FunCoupENSG00000131437
BioGRIDKIF3A
STRING (EMBL)KIF3A
ZODIACKIF3A
Ontologies - Pathways
QuickGOQ9Y496
Ontology : AmiGOprotein binding  ATP binding  centrosome  centriole  cytosol  spindle microtubule  cilium  cilium  retrograde vesicle-mediated transport, Golgi to ER  organelle organization  microtubule-based movement  microtubule binding  ATP-dependent microtubule motor activity, plus-end-directed  centriole-centriole cohesion  microtubule cytoskeleton  kinesin II complex  Rab GTPase binding  antigen processing and presentation of exogenous peptide antigen via MHC class II  neurogenesis  spectrin binding  microtubule anchoring at centrosome  intraciliary transport involved in cilium assembly  cilium assembly  cilium assembly  extracellular exosome  plus-end-directed vesicle transport along microtubule  ciliary tip  
Ontology : EGO-EBIprotein binding  ATP binding  centrosome  centriole  cytosol  spindle microtubule  cilium  cilium  retrograde vesicle-mediated transport, Golgi to ER  organelle organization  microtubule-based movement  microtubule binding  ATP-dependent microtubule motor activity, plus-end-directed  centriole-centriole cohesion  microtubule cytoskeleton  kinesin II complex  Rab GTPase binding  antigen processing and presentation of exogenous peptide antigen via MHC class II  neurogenesis  spectrin binding  microtubule anchoring at centrosome  intraciliary transport involved in cilium assembly  cilium assembly  cilium assembly  extracellular exosome  plus-end-directed vesicle transport along microtubule  ciliary tip  
NDEx NetworkKIF3A
Atlas of Cancer Signalling NetworkKIF3A
Wikipedia pathwaysKIF3A
Orthology - Evolution
OrthoDB11127
GeneTree (enSembl)ENSG00000131437
Phylogenetic Trees/Animal Genes : TreeFamKIF3A
HOVERGENQ9Y496
HOGENOMQ9Y496
Homologs : HomoloGeneKIF3A
Homology/Alignments : Family Browser (UCSC)KIF3A
Gene fusions - Rearrangements
Fusion : MitelmanALDOC/KIF3A [17q11.2/5q31.1]  [t(5;17)(q31;q11)]  
Fusion : MitelmanNDRG2/KIF3A [14q11.2/5q31.1]  [t(5;14)(q31;q11)]  
Fusion: TCGA_MDACCALDOC 17q11.2 KIF3A 5q31.1 LGG
Fusion: TCGA_MDACCNDRG2 14q11.2 KIF3A 5q31.1 LGG
Tumor Fusion PortalKIF3A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKIF3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KIF3A
dbVarKIF3A
ClinVarKIF3A
1000_GenomesKIF3A 
Exome Variant ServerKIF3A
ExAC (Exome Aggregation Consortium)ENSG00000131437
GNOMAD BrowserENSG00000131437
Genetic variants : HAPMAP11127
Genomic Variants (DGV)KIF3A [DGVbeta]
DECIPHERKIF3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKIF3A 
Mutations
ICGC Data PortalKIF3A 
TCGA Data PortalKIF3A 
Broad Tumor PortalKIF3A
OASIS PortalKIF3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKIF3A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKIF3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KIF3A
DgiDB (Drug Gene Interaction Database)KIF3A
DoCM (Curated mutations)KIF3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KIF3A (select a term)
intoGenKIF3A
Cancer3DKIF3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604683   
Orphanet
DisGeNETKIF3A
MedgenKIF3A
Genetic Testing Registry KIF3A
NextProtQ9Y496 [Medical]
TSGene11127
GENETestsKIF3A
Target ValidationKIF3A
Huge Navigator KIF3A [HugePedia]
snp3D : Map Gene to Disease11127
BioCentury BCIQKIF3A
ClinGenKIF3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11127
Chemical/Pharm GKB GenePA30102
Clinical trialKIF3A
Miscellaneous
canSAR (ICR)KIF3A (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKIF3A
EVEXKIF3A
GoPubMedKIF3A
iHOPKIF3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:18:56 CET 2017

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