KIF3B (kinesin family member 3B)

2012-11-01  

Identity

HGNC
LOCATION
20q11.21
LOCUSID
ALIAS
FLA8,HH0048,KLP-11,RP89
FUSION GENES

Other Information

Locus ID:

NCBI: 9371
MIM: 603754
HGNC: 6320
Ensembl: ENSG00000101350

Variants:

dbSNP: 9371
ClinVar: 9371
TCGA: ENSG00000101350
COSMIC: KIF3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101350ENST00000375712O15066

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Intraflagellar transportREACTOMER-HSA-5620924
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
189575122008The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling.79
170083582006Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin.46
162989992006Role of the kinesin-2 family protein, KIF3, during mitosis.32
199400362010CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.21
255888312015The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.19
287610022017Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load.15
153455582004The two motor domains of KIF3A/B coordinate for processive motility and move at different speeds.13
243684202014Suppression of KIF3B expression inhibits human hepatocellular carcinoma proliferation.13
193395492009Targeting of p0071 to the midbody depends on KIF3.9
281615392017A novel role of KIF3b in the seminoma cell cycle.6

Citation

Dessen P

KIF3B (kinesin family member 3B)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53015/kif3b