Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

KIF5B (kinesin family member 5B)

Identity

Alias_namesKNS1
Alias_symbol (synonym)KNS
Other aliasHEL-S-61
KINH
UKHC
HGNC (Hugo) KIF5B
LocusID (NCBI) 3799
Atlas_Id 42894
Location 10p11.22  [Link to chromosome band 10p11]
Location_base_pair Starts at 32009010 and ends at 32056443 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ALK (2p23.2) / KIF5B (10p11.22)ARHGAP12 (10p11.22) / KIF5B (10p11.22)C7orf49 (7q33) / KIF5B (10p11.22)
HHAT (1q32.2) / KIF5B (10p11.22)KIF5B (10p11.22) / ALK (2p23.2)KIF5B (10p11.22) / HHAT (1q32.2)
KIF5B (10p11.22) / HPS4 (22q12.1)KIF5B (10p11.22) / MET (7q31.2)KIF5B (10p11.22) / PDGFRA (4q12)
KIF5B (10p11.22) / RET (10q11.21)NFE2L2 (2q31.2) / KIF5B (10p11.22)RBPJ (4p15.2) / KIF5B (10p11.22)
RET (10q11.21) / KIF5B (10p11.22)SYNM (15q26.3) / KIF5B (10p11.22)KIF5B 10p11.22 / ALK 2p23.2
KIF5B 10p11.22 / RET 10q11.21HHAT 1q32.2 / KIF5B 10p11.22KIF5B 10p11.22 / HHAT 1q32.2
KIF5B 10p11.22 / HPS4 22q12.1KIF5B 10p11.22 / MET 7q31.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 5 ]
  del(4)(q12q12) FIP1L1/PDGFRA
ins(9;4)(q33;q12q25) CDK5RAP2/PDGFRA
t(2;4)(p22;q12) STRN/PDGFRA
t(4;10)(q12;p11) KIF5B/PDGFRA
t(4;12)(q12;p13) PDGFRA/ETV6


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Adenocarcinoma
Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)KIF5B   6324
Cards
Entrez_Gene (NCBI)KIF5B  3799  kinesin family member 5B
AliasesHEL-S-61; KINH; KNS; KNS1; 
UKHC
GeneCards (Weizmann)KIF5B
Ensembl hg19 (Hinxton)ENSG00000170759 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170759 [Gene_View]  chr10:32009010-32056443 [Contig_View]  KIF5B [Vega]
ICGC DataPortalENSG00000170759
TCGA cBioPortalKIF5B
AceView (NCBI)KIF5B
Genatlas (Paris)KIF5B
WikiGenes3799
SOURCE (Princeton)KIF5B
Genetics Home Reference (NIH)KIF5B
Genomic and cartography
GoldenPath hg38 (UCSC)KIF5B  -     chr10:32009010-32056443 -  10p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KIF5B  -     10p11.22   [Description]    (hg19-Feb_2009)
EnsemblKIF5B - 10p11.22 [CytoView hg19]  KIF5B - 10p11.22 [CytoView hg38]
Mapping of homologs : NCBIKIF5B [Mapview hg19]  KIF5B [Mapview hg38]
OMIM602809   
Gene and transcription
Genbank (Entrez)AK289413 AK299542 AK307502 BC010885 BC065267
RefSeq transcript (Entrez)NM_004521
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KIF5B
Cluster EST : UnigeneHs.327736 [ NCBI ]
CGAP (NCI)Hs.327736
Alternative Splicing GalleryENSG00000170759
Gene ExpressionKIF5B [ NCBI-GEO ]   KIF5B [ EBI - ARRAY_EXPRESS ]   KIF5B [ SEEK ]   KIF5B [ MEM ]
Gene Expression Viewer (FireBrowse)KIF5B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3799
GTEX Portal (Tissue expression)KIF5B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33176   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP33176  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP33176
Splice isoforms : SwissVarP33176
PhosPhoSitePlusP33176
Domaine pattern : Prosite (Expaxy)KINESIN_MOTOR_1 (PS00411)    KINESIN_MOTOR_2 (PS50067)   
Domains : Interpro (EBI)Kinesin_motor_CS    Kinesin_motor_dom    P-loop_NTPase   
Domain families : Pfam (Sanger)Kinesin (PF00225)   
Domain families : Pfam (NCBI)pfam00225   
Domain families : Smart (EMBL)KISc (SM00129)  
Conserved Domain (NCBI)KIF5B
DMDM Disease mutations3799
Blocks (Seattle)KIF5B
PDB (SRS)1BG2    1MKJ    2P4N    3J8X    3J8Y    4HNA    4LNU   
PDB (PDBSum)1BG2    1MKJ    2P4N    3J8X    3J8Y    4HNA    4LNU   
PDB (IMB)1BG2    1MKJ    2P4N    3J8X    3J8Y    4HNA    4LNU   
PDB (RSDB)1BG2    1MKJ    2P4N    3J8X    3J8Y    4HNA    4LNU   
Structural Biology KnowledgeBase1BG2    1MKJ    2P4N    3J8X    3J8Y    4HNA    4LNU   
SCOP (Structural Classification of Proteins)1BG2    1MKJ    2P4N    3J8X    3J8Y    4HNA    4LNU   
CATH (Classification of proteins structures)1BG2    1MKJ    2P4N    3J8X    3J8Y    4HNA    4LNU   
SuperfamilyP33176
Human Protein AtlasENSG00000170759
Peptide AtlasP33176
HPRD07214
IPIIPI00012837   IPI00909299   
Protein Interaction databases
DIP (DOE-UCLA)P33176
IntAct (EBI)P33176
FunCoupENSG00000170759
BioGRIDKIF5B
STRING (EMBL)KIF5B
ZODIACKIF5B
Ontologies - Pathways
QuickGOP33176
Ontology : AmiGOmicrotubule motor activity  protein binding  ATP binding  microtubule organizing center  cytosol  kinesin complex  microtubule  microtubule-based movement  cytoplasm organization  axon guidance  microtubule binding  JUN kinase binding  ATP-dependent microtubule motor activity, plus-end-directed  membrane  hippocampus development  endocytic vesicle  cytoskeleton-dependent intracellular transport  positive regulation of vesicle fusion  vesicle  positive regulation of synaptic transmission, GABAergic  ciliary rootlet  stress granule disassembly  positive regulation of insulin secretion involved in cellular response to glucose stimulus  regulation of membrane potential  positive regulation of potassium ion transport  axonal growth cone  cadherin binding  vesicle transport along microtubule  perinuclear region of cytoplasm  centrosome localization  plus-end-directed vesicle transport along microtubule  positive regulation of establishment of protein localization to plasma membrane  positive regulation of intracellular protein transport  microtubule lateral binding  positive regulation of voltage-gated sodium channel activity  
Ontology : EGO-EBImicrotubule motor activity  protein binding  ATP binding  microtubule organizing center  cytosol  kinesin complex  microtubule  microtubule-based movement  cytoplasm organization  axon guidance  microtubule binding  JUN kinase binding  ATP-dependent microtubule motor activity, plus-end-directed  membrane  hippocampus development  endocytic vesicle  cytoskeleton-dependent intracellular transport  positive regulation of vesicle fusion  vesicle  positive regulation of synaptic transmission, GABAergic  ciliary rootlet  stress granule disassembly  positive regulation of insulin secretion involved in cellular response to glucose stimulus  regulation of membrane potential  positive regulation of potassium ion transport  axonal growth cone  cadherin binding  vesicle transport along microtubule  perinuclear region of cytoplasm  centrosome localization  plus-end-directed vesicle transport along microtubule  positive regulation of establishment of protein localization to plasma membrane  positive regulation of intracellular protein transport  microtubule lateral binding  positive regulation of voltage-gated sodium channel activity  
Pathways : KEGGDopaminergic synapse   
NDEx NetworkKIF5B
Atlas of Cancer Signalling NetworkKIF5B
Wikipedia pathwaysKIF5B
Orthology - Evolution
OrthoDB3799
GeneTree (enSembl)ENSG00000170759
Phylogenetic Trees/Animal Genes : TreeFamKIF5B
HOVERGENP33176
HOGENOMP33176
Homologs : HomoloGeneKIF5B
Homology/Alignments : Family Browser (UCSC)KIF5B
Gene fusions - Rearrangements
Fusion : MitelmanHHAT/KIF5B [1q32.2/10p11.22]  [t(1;10)(q32;p11)]  
Fusion : MitelmanKIF5B/ALK [10p11.22/2p23.2]  [t(2;10)(p23;p11)]  
Fusion : MitelmanKIF5B/HHAT [10p11.22/1q32.2]  [t(1;10)(q32;p11)]  
Fusion : MitelmanKIF5B/HPS4 [10p11.22/22q12.1]  [t(10;22)(p11;q12)]  
Fusion : MitelmanKIF5B/MET [10p11.22/7q31.2]  [t(7;10)(q31;p11)]  
Fusion : MitelmanKIF5B/PDGFRA [10p11.22/4q12]  [t(4;10)(q12;p11)]  
Fusion : MitelmanKIF5B/RET [10p11.22/10q11.21]  [inv(10)(p11q11)]  
Fusion: TCGAHHAT 1q32.2 KIF5B 10p11.22 PRAD
Fusion: TCGAKIF5B 10p11.22 HHAT 1q32.2 PRAD
Fusion: TCGAKIF5B 10p11.22 HPS4 22q12.1 BRCA
Fusion: TCGAKIF5B 10p11.22 MET 7q31.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKIF5B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KIF5B
dbVarKIF5B
ClinVarKIF5B
1000_GenomesKIF5B 
Exome Variant ServerKIF5B
ExAC (Exome Aggregation Consortium)KIF5B (select the gene name)
Genetic variants : HAPMAP3799
Genomic Variants (DGV)KIF5B [DGVbeta]
DECIPHERKIF5B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKIF5B 
Mutations
ICGC Data PortalKIF5B 
TCGA Data PortalKIF5B 
Broad Tumor PortalKIF5B
OASIS PortalKIF5B [ Somatic mutations - Copy number]
Cancer Gene: CensusKIF5B 
Somatic Mutations in Cancer : COSMICKIF5B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKIF5B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KIF5B
DgiDB (Drug Gene Interaction Database)KIF5B
DoCM (Curated mutations)KIF5B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KIF5B (select a term)
intoGenKIF5B
Cancer3DKIF5B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602809   
Orphanet
MedgenKIF5B
Genetic Testing Registry KIF5B
NextProtP33176 [Medical]
TSGene3799
GENETestsKIF5B
Target ValidationKIF5B
Huge Navigator KIF5B [HugePedia]
snp3D : Map Gene to Disease3799
BioCentury BCIQKIF5B
ClinGenKIF5B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3799
Chemical/Pharm GKB GenePA30108
Clinical trialKIF5B
Miscellaneous
canSAR (ICR)KIF5B (select the gene name)
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKIF5B
EVEXKIF5B
GoPubMedKIF5B
iHOPKIF5B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:14:30 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.