KIF5B (kinesin family member 5B)

2006-12-01  

Identity

HGNC
KIF5B
LOCATION
10p11.22
LOCUSID
3799
ALIAS
HEL-S-61,KINH,KNS,KNS1,UKHC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3799
MIM: 602809
HGNC: 6324
Ensembl: ENSG00000170759

Variants:

dbSNP: 3799
ClinVar: 3799
TCGA: ENSG00000170759
COSMIC: KIF5B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170759ENST00000302418P33176
ENSG00000170759ENST00000302418V9HW29

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate KTN1REACTOMER-HSA-5625970
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
223276242012KIF5B-RET fusions in lung adenocarcinoma.251
162606072005CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.89
221726772011Arl8 and SKIP act together to link lysosomes to kinesin-1.81
219251092011Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection.71
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
252312972014HIV-1 uncoating is facilitated by dynein and kinesin 1.64
255169772015Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.53
178879602007Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.50
179252272007Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cells.50
185797802008The kinesin-1 motor protein is regulated by a direct interaction of its head and tail.48

Citation

Dessen P

KIF5B (kinesin family member 5B)

Atlas Genet Cytogenet Oncol Haematol. 2006-12-01

Online version: http://atlasgeneticsoncology.org/gene/42894/kif5b