KIF6 (kinesin family member 6)

2012-11-01  

Identity

HGNC
KIF6
LOCATION
6p21.2
LOCUSID
221458
ALIAS
C6orf102,dJ1043E3.1,dJ137F1.4,dJ188D3.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 221458
MIM: 613919
HGNC: 21202
Ensembl: ENSG00000164627

Variants:

dbSNP: 221458
ClinVar: 221458
TCGA: ENSG00000164627
COSMIC: KIF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164627ENST00000229913Q6ZMV9
ENSG00000164627ENST00000287152Q6ZMV9
ENSG00000164627ENST00000394362Q2MDE8
ENSG00000164627ENST00000441975Q5JRK0
ENSG00000164627ENST00000458470H0Y718
ENSG00000164627ENST00000538893F6VGH2

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134308647rosuvastatinChemicalClinicalAnnotationassociatedPD30304062
PA443797Coronary DiseaseDiseaseClinicalAnnotationassociatedPD18222353, 18222355, 20215968, 20403483, 30304062
PA444516HypercholesterolemiaDiseaseClinicalAnnotationassociatedPD18222353, 18222355, 21458191, 30304062
PA445019Myocardial InfarctionDiseaseClinicalAnnotationassociatedPD18222353, 18222355, 20215968, 20403483, 30304062
PA448500atorvastatinChemicalClinicalAnnotationassociatedPD18222353, 18222355, 20215968, 20403483, 30304062
PA451089pravastatinChemicalClinicalAnnotationassociatedPD18222353, 18222355, 20215968, 20403483
PA451363simvastatinChemicalClinicalAnnotationassociatedPD21458191, 30304062

References

Pubmed IDYearTitleCitations
179751192008Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
182223532008Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.51
182223532008Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.51
182223552008Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study.48
182223552008Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study.48
180735812007Five common gene variants identify elevated genetic risk for coronary heart disease.43
182223542008A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study.34
182223542008A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study.34
209333572010Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.34

Citation

Dessen P

KIF6 (kinesin family member 6)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52959/kif6