KIR2DL2 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2)

2009-09-01 Affiliation

HGNC

KIR2DL2

LOCATION

19q13.42

LOCUSID

3803

ALIAS

CD158B1,CD158b,NKAT-6,NKAT6,p58.2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

NCBI: 3803
MIM: 604937
HGNC: 6330

dbSNP: 3803
ClinVar: 3803
COSMIC: KIR2DL2

Pathway	Source	External ID
Antigen processing and presentation	KEGG	ko04612
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Graft-versus-host disease	KEGG	ko05332
Antigen processing and presentation	KEGG	hsa04612
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Graft-versus-host disease	KEGG	hsa05332
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933

Pubmed ID	Year	Title	Citations
18945962	2009	Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.	166
18322206	2008	Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.	148
20935224	2010	Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy.	80
19934297	2009	KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.	50
15879158	2005	Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors.	46
22772445	2012	Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.	42
17200871	2007	KIR haplotype content at the allele level in 77 Northern Irish families.	36
18945643	2009	DNA methylation inhibition increases T cell KIR expression through effects on both promoter methylation and transcription factors.	35
15140215	2004	Genetic polymorphisms of killer cell immunoglobulin-like receptors are associated with susceptibility to psoriasis vulgaris.	34
20878400	2010	Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.	32

Dessen P

KIR2DL2 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01