KIR2DL3 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3)

2012-01-01 Affiliation

Identity

HGNC

KIR2DL3

LOCATION

19q13.42

LOCUSID

3804

ALIAS

CD158B2,CD158b,GL183,KIR-023GB,KIR-K7b,KIR-K7c,KIR2DL,KIR2DS5,KIRCL23,NKAT,NKAT2,NKAT2A,NKAT2B,p58

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3804
MIM: 604938
HGNC: 6331
Ensembl: ENSG00000243772

Variants:

dbSNP: 3804
ClinVar: 3804
TCGA: ENSG00000243772
COSMIC: KIR2DL3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000243772	ENST00000342376	P43628
ENSG00000243772	ENST00000342376	E3NZD8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Antigen processing and presentation	KEGG	ko04612
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Graft-versus-host disease	KEGG	ko05332
Antigen processing and presentation	KEGG	hsa04612
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Graft-versus-host disease	KEGG	hsa05332
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933

References

Pubmed ID	Year	Title	Citations
15297676	2004	HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection.	402
18322206	2008	Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.	148
20935224	2010	Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy.	80
20077564	2010	Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus.	64
20077564	2010	Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus.	64
19837691	2009	Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands.	53
19934297	2009	KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.	50
21931540	2011	IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study.	47
15879158	2005	Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors.	46
18289678	2008	Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome.	42

Citation

Dessen P

KIR2DL3 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/43615/kir2dl3