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KIRREL3 (kin of IRRE like 3 (Drosophila))

Identity

Alias_symbol (synonym)NEPH2
KIAA1867
KIRRE
Other aliasMRD4
PRO4502
HGNC (Hugo) KIRREL3
LocusID (NCBI) 84623
Atlas_Id 64939
Location 11q24.2  [Link to chromosome band 11q24]
Location_base_pair Starts at 126430942 and ends at 127000870 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACP2 (11p11.2) / KIRREL3 (11q24.2)KIF1C (17p13.2) / KIRREL3 (11q24.2)KIRREL3 (11q24.2) / CDH15 (16q24.3)
KIRREL3 (11q24.2) / HNRNPUL1 (19q13.2)KIRREL3 (11q24.2) / KIRREL3 (11q24.2)MLLT6 (17q12) / KIRREL3 (11q24.2)
RP11-680F20.9 () / KIRREL3 (11q24.2)UVRAG (11q13.5) / KIRREL3 (11q24.2)RP11-680F20.9 KIRREL3
MLLT6 KIRREL3UVRAG KIRREL3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;11)(q13;q24) UVRAG/KIRREL3
t(11;17)(q24;q12) MLLT6/KIRREL3

External links

Nomenclature
HGNC (Hugo)KIRREL3   23204
Cards
Entrez_Gene (NCBI)KIRREL3  84623  kin of IRRE like 3 (Drosophila)
AliasesKIRRE; MRD4; NEPH2; PRO4502
GeneCards (Weizmann)KIRREL3
Ensembl hg19 (Hinxton)ENSG00000149571 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149571 [Gene_View]  chr11:126430942-127000870 [Contig_View]  KIRREL3 [Vega]
ICGC DataPortalENSG00000149571
TCGA cBioPortalKIRREL3
AceView (NCBI)KIRREL3
Genatlas (Paris)KIRREL3
WikiGenes84623
SOURCE (Princeton)KIRREL3
Genetics Home Reference (NIH)KIRREL3
Genomic and cartography
GoldenPath hg38 (UCSC)KIRREL3  -     chr11:126430942-127000870 -  11q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KIRREL3  -     11q24.2   [Description]    (hg19-Feb_2009)
EnsemblKIRREL3 - 11q24.2 [CytoView hg19]  KIRREL3 - 11q24.2 [CytoView hg38]
Mapping of homologs : NCBIKIRREL3 [Mapview hg19]  KIRREL3 [Mapview hg38]
OMIM607761   612581   
Gene and transcription
Genbank (Entrez)AB058770 AF480410 AK092047 AK300108 AY358743
RefSeq transcript (Entrez)NM_001161707 NM_001301097 NM_032531
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KIRREL3
Cluster EST : UnigeneHs.376015 [ NCBI ]
CGAP (NCI)Hs.376015
Alternative Splicing GalleryENSG00000149571
Gene ExpressionKIRREL3 [ NCBI-GEO ]   KIRREL3 [ EBI - ARRAY_EXPRESS ]   KIRREL3 [ SEEK ]   KIRREL3 [ MEM ]
Gene Expression Viewer (FireBrowse)KIRREL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84623
GTEX Portal (Tissue expression)KIRREL3
Human Protein AtlasENSG00000149571-KIRREL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IZU9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IZU9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IZU9
Splice isoforms : SwissVarQ8IZU9
PhosPhoSitePlusQ8IZU9
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2   
Domain families : Pfam (Sanger)I-set (PF07679)    Ig_2 (PF13895)   
Domain families : Pfam (NCBI)pfam07679    pfam13895   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)KIRREL3
DMDM Disease mutations84623
Blocks (Seattle)KIRREL3
PDB (SRS)2CRY   
PDB (PDBSum)2CRY   
PDB (IMB)2CRY   
PDB (RSDB)2CRY   
Structural Biology KnowledgeBase2CRY   
SCOP (Structural Classification of Proteins)2CRY   
CATH (Classification of proteins structures)2CRY   
SuperfamilyQ8IZU9
Human Protein Atlas [tissue]ENSG00000149571-KIRREL3 [tissue]
Peptide AtlasQ8IZU9
HPRD09679
IPIIPI00218082   IPI00432312   IPI00984912   
Protein Interaction databases
DIP (DOE-UCLA)Q8IZU9
IntAct (EBI)Q8IZU9
FunCoupENSG00000149571
BioGRIDKIRREL3
STRING (EMBL)KIRREL3
ZODIACKIRREL3
Ontologies - Pathways
QuickGOQ8IZU9
Ontology : AmiGO###############################################################################################################################################################################################################################################################                                
Ontology : EGO-EBI###############################################################################################################################################################################################################################################################                                
NDEx NetworkKIRREL3
Atlas of Cancer Signalling NetworkKIRREL3
Wikipedia pathwaysKIRREL3
Orthology - Evolution
OrthoDB84623
GeneTree (enSembl)ENSG00000149571
Phylogenetic Trees/Animal Genes : TreeFamKIRREL3
HOVERGENQ8IZU9
HOGENOMQ8IZU9
Homologs : HomoloGeneKIRREL3
Homology/Alignments : Family Browser (UCSC)KIRREL3
Gene fusions - Rearrangements
Fusion: TCGA_MDACCRP11-680F20.9 KIRREL3
Fusion: TCGA_MDACCMLLT6 KIRREL3
Fusion: TCGA_MDACCUVRAG KIRREL3
Fusion PortalRP11-680F20.9 KIRREL3
Fusion PortalMLLT6 KIRREL3
Fusion PortalUVRAG KIRREL3
Fusion : QuiverKIRREL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKIRREL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KIRREL3
dbVarKIRREL3
ClinVarKIRREL3
1000_GenomesKIRREL3 
Exome Variant ServerKIRREL3
ExAC (Exome Aggregation Consortium)ENSG00000149571
GNOMAD BrowserENSG00000149571
Genetic variants : HAPMAP84623
Genomic Variants (DGV)KIRREL3 [DGVbeta]
DECIPHERKIRREL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKIRREL3 
Mutations
ICGC Data PortalKIRREL3 
TCGA Data PortalKIRREL3 
Broad Tumor PortalKIRREL3
OASIS PortalKIRREL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKIRREL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKIRREL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KIRREL3
DgiDB (Drug Gene Interaction Database)KIRREL3
DoCM (Curated mutations)KIRREL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KIRREL3 (select a term)
intoGenKIRREL3
Cancer3DKIRREL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607761    612581   
Orphanet18028   
DisGeNETKIRREL3
MedgenKIRREL3
Genetic Testing Registry KIRREL3
NextProtQ8IZU9 [Medical]
TSGene84623
GENETestsKIRREL3
Target ValidationKIRREL3
Huge Navigator KIRREL3 [HugePedia]
snp3D : Map Gene to Disease84623
BioCentury BCIQKIRREL3
ClinGenKIRREL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84623
Chemical/Pharm GKB GenePA134958283
Clinical trialKIRREL3
Miscellaneous
canSAR (ICR)KIRREL3 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKIRREL3
EVEXKIRREL3
GoPubMedKIRREL3
iHOPKIRREL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Feb 23 18:22:56 CET 2018
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