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KISS1 (KiSS-1 metastasis suppressor)

Identity

Other aliasHH13
KiSS-1
HGNC (Hugo) KISS1
LocusID (NCBI) 3814
Atlas_Id 41072
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 204190341 and ends at 204196491 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GOLT1A (1q32.1) / KISS1 (1q32.1)KISS1 (1q32.1) / PSEN1 (14q24.2)PPP1R12C (19q13.42) / KISS1 (1q32.1)
PPP1R12C 19q13.42 / KISS1 1q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;19)(q32;q13) PPP1R12C/KISS1


External links

Nomenclature
HGNC (Hugo)KISS1   6341
Cards
Entrez_Gene (NCBI)KISS1  3814  KiSS-1 metastasis suppressor
AliasesHH13; KiSS-1
GeneCards (Weizmann)KISS1
Ensembl hg19 (Hinxton)ENSG00000170498 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170498 [Gene_View]  ENSG00000170498 [Sequence]  chr1:204190341-204196491 [Contig_View]  KISS1 [Vega]
ICGC DataPortalENSG00000170498
TCGA cBioPortalKISS1
AceView (NCBI)KISS1
Genatlas (Paris)KISS1
WikiGenes3814
SOURCE (Princeton)KISS1
Genetics Home Reference (NIH)KISS1
Genomic and cartography
GoldenPath hg38 (UCSC)KISS1  -     chr1:204190341-204196491 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KISS1  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblKISS1 - 1q32.1 [CytoView hg19]  KISS1 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIKISS1 [Mapview hg19]  KISS1 [Mapview hg38]
OMIM603286   614842   
Gene and transcription
Genbank (Entrez)AF218017 AK291695 AY117143 BC022819 U43527
RefSeq transcript (Entrez)NM_002256
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KISS1
Cluster EST : UnigeneHs.95008 [ NCBI ]
CGAP (NCI)Hs.95008
Alternative Splicing GalleryENSG00000170498
Gene ExpressionKISS1 [ NCBI-GEO ]   KISS1 [ EBI - ARRAY_EXPRESS ]   KISS1 [ SEEK ]   KISS1 [ MEM ]
Gene Expression Viewer (FireBrowse)KISS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3814
GTEX Portal (Tissue expression)KISS1
Human Protein AtlasENSG00000170498-KISS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15726   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15726  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15726
Splice isoforms : SwissVarQ15726
PhosPhoSitePlusQ15726
Domains : Interpro (EBI)Metastasis-suppressor_KiSS-1   
Domain families : Pfam (Sanger)Kisspeptin (PF15152)   
Domain families : Pfam (NCBI)pfam15152   
Domain structure : Prodom (Prabi Lyon)Metastasis-suppressor_KiSS-1 (PD088121)   
Conserved Domain (NCBI)KISS1
DMDM Disease mutations3814
Blocks (Seattle)KISS1
SuperfamilyQ15726
Human Protein Atlas [tissue]ENSG00000170498-KISS1 [tissue]
Peptide AtlasQ15726
HPRD04475
IPIIPI00301950   
Protein Interaction databases
DIP (DOE-UCLA)Q15726
IntAct (EBI)Q15726
FunCoupENSG00000170498
BioGRIDKISS1
STRING (EMBL)KISS1
ZODIACKISS1
Ontologies - Pathways
QuickGOQ15726
Ontology : AmiGOprotein binding  extracellular region  extracellular space  cytoplasm  cytoskeleton organization  G-protein coupled receptor signaling pathway  negative regulation of cell proliferation  apical plasma membrane  kisspeptin receptor binding  positive regulation of luteinizing hormone secretion  neuron projection  neuronal cell body  positive regulation of MAPK cascade  positive regulation of synaptic transmission  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  generation of ovulation cycle rhythm  positive regulation of growth hormone secretion  
Ontology : EGO-EBIprotein binding  extracellular region  extracellular space  cytoplasm  cytoskeleton organization  G-protein coupled receptor signaling pathway  negative regulation of cell proliferation  apical plasma membrane  kisspeptin receptor binding  positive regulation of luteinizing hormone secretion  neuron projection  neuronal cell body  positive regulation of MAPK cascade  positive regulation of synaptic transmission  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  generation of ovulation cycle rhythm  positive regulation of growth hormone secretion  
NDEx NetworkKISS1
Atlas of Cancer Signalling NetworkKISS1
Wikipedia pathwaysKISS1
Orthology - Evolution
OrthoDB3814
GeneTree (enSembl)ENSG00000170498
Phylogenetic Trees/Animal Genes : TreeFamKISS1
HOVERGENQ15726
HOGENOMQ15726
Homologs : HomoloGeneKISS1
Homology/Alignments : Family Browser (UCSC)KISS1
Gene fusions - Rearrangements
Fusion : MitelmanPPP1R12C/KISS1 [19q13.42/1q32.1]  [t(1;19)(q32;q13)]  
Fusion PortalPPP1R12C 19q13.42 KISS1 1q32.1 BRCA
Fusion : QuiverKISS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKISS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KISS1
dbVarKISS1
ClinVarKISS1
1000_GenomesKISS1 
Exome Variant ServerKISS1
ExAC (Exome Aggregation Consortium)ENSG00000170498
GNOMAD BrowserENSG00000170498
Genetic variants : HAPMAP3814
Genomic Variants (DGV)KISS1 [DGVbeta]
DECIPHERKISS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKISS1 
Mutations
ICGC Data PortalKISS1 
TCGA Data PortalKISS1 
Broad Tumor PortalKISS1
OASIS PortalKISS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKISS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKISS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KISS1
DgiDB (Drug Gene Interaction Database)KISS1
DoCM (Curated mutations)KISS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KISS1 (select a term)
intoGenKISS1
Cancer3DKISS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603286    614842   
Orphanet8668   
DisGeNETKISS1
MedgenKISS1
Genetic Testing Registry KISS1
NextProtQ15726 [Medical]
TSGene3814
GENETestsKISS1
Target ValidationKISS1
Huge Navigator KISS1 [HugePedia]
snp3D : Map Gene to Disease3814
BioCentury BCIQKISS1
ClinGenKISS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3814
Chemical/Pharm GKB GenePA30127
Clinical trialKISS1
Miscellaneous
canSAR (ICR)KISS1 (select the gene name)
Probes
Litterature
PubMed224 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKISS1
EVEXKISS1
GoPubMedKISS1
iHOPKISS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:32:14 CEST 2018

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