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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

Donate (in Euros)

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KL (klotho)

Identity

Other names-
HGNC (Hugo) KL
LocusID (NCBI) 9365
Location 13q13.1
Location_base_pair Starts at 33590571 and ends at 33640282 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)KL   6344
Cards
Entrez_Gene (NCBI)KL  9365  klotho
GeneCards (Weizmann)KL
Ensembl hg19 (Hinxton)ENSG00000133116 [Gene_View]  chr13:33590571-33640282 [Contig_View]  KL [Vega]
Ensembl hg38 (Hinxton)ENSG00000133116 [Gene_View]  chr13:33590571-33640282 [Contig_View]  KL [Vega]
ICGC DataPortalENSG00000133116
cBioPortalKL
AceView (NCBI)KL
Genatlas (Paris)KL
WikiGenes9365
SOURCE (Princeton)KL
Genomic and cartography
GoldenPath hg19 (UCSC)KL  -     chr13:33590571-33640282 +  13q13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KL  -     13q13.1   [Description]    (hg38-Dec_2013)
EnsemblKL - 13q13.1 [CytoView hg19]  KL - 13q13.1 [CytoView hg38]
Mapping of homologs : NCBIKL [Mapview hg19]  KL [Mapview hg38]
OMIM604824   
Gene and transcription
Genbank (Entrez)AA890465 AB005142 AK097349 CB988086
RefSeq transcript (Entrez)NM_004795 NM_153683
RefSeq genomic (Entrez)AC_000145 NC_000013 NC_018924 NG_011485 NT_024524 NW_001838072 NW_004929388
Consensus coding sequences : CCDS (NCBI)KL
Cluster EST : UnigeneHs.524953 [ NCBI ]
CGAP (NCI)Hs.524953
Alternative Splicing : Fast-db (Paris)GSHG0008038
Alternative Splicing GalleryENSG00000133116
Gene ExpressionKL [ NCBI-GEO ]     KL [ SEEK ]   KL [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UEF7 (Uniprot)
NextProtQ9UEF7  [Medical]
With graphics : InterProQ9UEF7
Splice isoforms : SwissVarQ9UEF7 (Swissvar)
Catalytic activity : Enzyme3.2.1.31 [ Enzyme-Expasy ]   3.2.1.313.2.1.31 [ IntEnz-EBI ]   3.2.1.31 [ BRENDA ]   3.2.1.31 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)GLYCOSYL_HYDROL_F1_2 (PS00653)   
Domains : Interpro (EBI)Glyco_hydro_1    Glyco_hydro_1_AS    Glyco_hydro_catalytic_dom    Glycoside_hydrolase_SF    Klotho   
Related proteins : CluSTrQ9UEF7
Domain families : Pfam (Sanger)Glyco_hydro_1 (PF00232)   
Domain families : Pfam (NCBI)pfam00232   
DMDM Disease mutations9365
Blocks (Seattle)Q9UEF7
Human Protein AtlasENSG00000133116
Peptide AtlasQ9UEF7
HPRD05316
IPIIPI00295265   IPI00170818   IPI01009167   
Protein Interaction databases
DIP (DOE-UCLA)Q9UEF7
IntAct (EBI)Q9UEF7
FunCoupENSG00000133116
BioGRIDKL
IntegromeDBKL
STRING (EMBL)KL
Ontologies - Pathways
QuickGOQ9UEF7
Ontology : AmiGOacute inflammatory response  beta-glucuronidase activity  signal transducer activity  fibroblast growth factor receptor binding  hormone activity  vitamin D binding  extracellular region  extracellular space  extracellular space  plasma membrane  integral component of plasma membrane  carbohydrate metabolic process  energy reserve metabolic process  epidermal growth factor receptor signaling pathway  aging  insulin receptor signaling pathway  beta-glucosidase activity  fibroblast growth factor receptor signaling pathway  integral component of membrane  fibroblast growth factor binding  positive regulation of bone mineralization  Fc-epsilon receptor signaling pathway  innate immune response  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  calcium ion homeostasis  extracellular vesicular exosome  positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  
Ontology : EGO-EBIacute inflammatory response  beta-glucuronidase activity  signal transducer activity  fibroblast growth factor receptor binding  hormone activity  vitamin D binding  extracellular region  extracellular space  extracellular space  plasma membrane  integral component of plasma membrane  carbohydrate metabolic process  energy reserve metabolic process  epidermal growth factor receptor signaling pathway  aging  insulin receptor signaling pathway  beta-glucosidase activity  fibroblast growth factor receptor signaling pathway  integral component of membrane  fibroblast growth factor binding  positive regulation of bone mineralization  Fc-epsilon receptor signaling pathway  innate immune response  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  calcium ion homeostasis  extracellular vesicular exosome  positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  
Pathways : KEGGPentose and glucuronate interconversions    Starch and sucrose metabolism    Endocrine and other factor-regulated calcium reabsorption   
Protein Interaction DatabaseKL
DoCM (Curated mutations)KL
Wikipedia pathwaysKL
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerKL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KL
dbVarKL
ClinVarKL
1000_GenomesKL 
Exome Variant ServerKL
SNP (GeneSNP Utah)KL
SNP : HGBaseKL
Genetic variants : HAPMAPKL
Genomic Variants (DGV)KL [DGVbeta]
Mutations
ICGC Data PortalENSG00000133116 
Somatic Mutations in Cancer : COSMICKL 
CONAN: Copy Number AnalysisKL 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)The Globin Gene Server
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)13:33590571-33640282
Mutations and Diseases : HGMDKL
OMIM604824   
MedgenKL
NextProtQ9UEF7 [Medical]
GENETestsKL
Disease Genetic AssociationKL
Huge Navigator KL [HugePedia]  KL [HugeCancerGEM]
snp3D : Map Gene to Disease9365
DGIdb (Drug Gene Interaction db)KL
General knowledge
Homologs : HomoloGeneKL
Homology/Alignments : Family Browser (UCSC)KL
Phylogenetic Trees/Animal Genes : TreeFamKL
Chemical/Protein Interactions : CTD9365
Chemical/Pharm GKB GenePA30130
Clinical trialKL
Cancer Resource (Charite)ENSG00000133116
Other databases
Probes
Litterature
PubMed177 Pubmed reference(s) in Entrez
CoreMineKL
GoPubMedKL
iHOPKL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 14 16:29:14 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.