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KLB (klotho beta)

Identity

Other aliasBKL
HGNC (Hugo) KLB
LocusID (NCBI) 152831
Atlas_Id 51724
Location 4p14  [Link to chromosome band 4p14]
Location_base_pair Starts at 39406853 and ends at 39451533 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLB   15527
Cards
Entrez_Gene (NCBI)KLB  152831  klotho beta
AliasesBKL
GeneCards (Weizmann)KLB
Ensembl hg19 (Hinxton)ENSG00000134962 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134962 [Gene_View]  chr4:39406853-39451533 [Contig_View]  KLB [Vega]
ICGC DataPortalENSG00000134962
TCGA cBioPortalKLB
AceView (NCBI)KLB
Genatlas (Paris)KLB
WikiGenes152831
SOURCE (Princeton)KLB
Genetics Home Reference (NIH)KLB
Genomic and cartography
GoldenPath hg38 (UCSC)KLB  -     chr4:39406853-39451533 +  4p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLB  -     4p14   [Description]    (hg19-Feb_2009)
EnsemblKLB - 4p14 [CytoView hg19]  KLB - 4p14 [CytoView hg38]
Mapping of homologs : NCBIKLB [Mapview hg19]  KLB [Mapview hg38]
OMIM611135   
Gene and transcription
Genbank (Entrez)AB079373 AK302436 BC033021 BC104871 BC113653
RefSeq transcript (Entrez)NM_175737
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLB
Cluster EST : UnigeneHs.90756 [ NCBI ]
CGAP (NCI)Hs.90756
Alternative Splicing GalleryENSG00000134962
Gene ExpressionKLB [ NCBI-GEO ]   KLB [ EBI - ARRAY_EXPRESS ]   KLB [ SEEK ]   KLB [ MEM ]
Gene Expression Viewer (FireBrowse)KLB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)152831
GTEX Portal (Tissue expression)KLB
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86Z14   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86Z14  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86Z14
Splice isoforms : SwissVarQ86Z14
PhosPhoSitePlusQ86Z14
Domains : Interpro (EBI)Glyco_hydro_1    Glyco_hydro_catalytic_dom    Glycoside_hydrolase_SF   
Domain families : Pfam (Sanger)Glyco_hydro_1 (PF00232)   
Domain families : Pfam (NCBI)pfam00232   
Conserved Domain (NCBI)KLB
DMDM Disease mutations152831
Blocks (Seattle)KLB
SuperfamilyQ86Z14
Human Protein AtlasENSG00000134962
Peptide AtlasQ86Z14
HPRD14097
IPIIPI00179694   
Protein Interaction databases
DIP (DOE-UCLA)Q86Z14
IntAct (EBI)Q86Z14
FunCoupENSG00000134962
BioGRIDKLB
STRING (EMBL)KLB
ZODIACKLB
Ontologies - Pathways
QuickGOQ86Z14
Ontology : AmiGOMAPK cascade  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  protein binding  intracellular  plasma membrane  integral component of plasma membrane  carbohydrate metabolic process  positive regulation of cell proliferation  beta-glucosidase activity  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-3-kinase activity  fibroblast growth factor binding  phosphatidylinositol-3-phosphate biosynthetic process  positive regulation of GTPase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  glycosyl compound metabolic process  
Ontology : EGO-EBIMAPK cascade  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  protein binding  intracellular  plasma membrane  integral component of plasma membrane  carbohydrate metabolic process  positive regulation of cell proliferation  beta-glucosidase activity  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-3-kinase activity  fibroblast growth factor binding  phosphatidylinositol-3-phosphate biosynthetic process  positive regulation of GTPase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  glycosyl compound metabolic process  
NDEx NetworkKLB
Atlas of Cancer Signalling NetworkKLB
Wikipedia pathwaysKLB
Orthology - Evolution
OrthoDB152831
GeneTree (enSembl)ENSG00000134962
Phylogenetic Trees/Animal Genes : TreeFamKLB
HOVERGENQ86Z14
HOGENOMQ86Z14
Homologs : HomoloGeneKLB
Homology/Alignments : Family Browser (UCSC)KLB
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLB
dbVarKLB
ClinVarKLB
1000_GenomesKLB 
Exome Variant ServerKLB
ExAC (Exome Aggregation Consortium)KLB (select the gene name)
Genetic variants : HAPMAP152831
Genomic Variants (DGV)KLB [DGVbeta]
DECIPHERKLB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLB 
Mutations
ICGC Data PortalKLB 
TCGA Data PortalKLB 
Broad Tumor PortalKLB
OASIS PortalKLB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLB
DgiDB (Drug Gene Interaction Database)KLB
DoCM (Curated mutations)KLB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLB (select a term)
intoGenKLB
Cancer3DKLB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611135   
Orphanet
MedgenKLB
Genetic Testing Registry KLB
NextProtQ86Z14 [Medical]
TSGene152831
GENETestsKLB
Huge Navigator KLB [HugePedia]
snp3D : Map Gene to Disease152831
BioCentury BCIQKLB
ClinGenKLB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD152831
Chemical/Pharm GKB GenePA142671586
Clinical trialKLB
Miscellaneous
canSAR (ICR)KLB (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLB
EVEXKLB
GoPubMedKLB
iHOPKLB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:21:41 CEST 2017

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