Identity
HGNC
LOCATION
14q32.33
LOCUSID
ALIAS
KLC,KNS2,KNS2A
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3831
MIM: 600025
HGNC: 6387
Ensembl: ENSG00000126214
Variants:
dbSNP: 3831
ClinVar: 3831
TCGA: ENSG00000126214
COSMIC: KLC1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | 17549067 | |
| PA446108 | Colorectal Neoplasms | Disease | ClinicalAnnotation | associated | PD | 17549067 | |
| PA450085 | irinotecan | Chemical | ClinicalAnnotation | associated | PD | 17549067 | |
| PA450198 | leucovorin | Chemical | ClinicalAnnotation | associated | PD | 17549067 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38768546 | 2024 | Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing. | 0 |
| 38768546 | 2024 | Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing. | 0 |
| 33691783 | 2021 | Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport. | 3 |
| 33691783 | 2021 | Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport. | 3 |
| 31068217 | 2019 | LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains. | 12 |
| 31204277 | 2019 | A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis. | 12 |
| 31806024 | 2019 | Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein. | 19 |
| 31068217 | 2019 | LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains. | 12 |
| 31204277 | 2019 | A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis. | 12 |
| 31806024 | 2019 | Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein. | 19 |
| 29445114 | 2018 | Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B. | 12 |
| 30026235 | 2018 | Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1). | 3 |
| 29445114 | 2018 | Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B. | 12 |
| 30026235 | 2018 | Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1). | 3 |
| 27891669 | 2017 | A molecular dynamics study of the binary complexes of APP, JIP1, and the cargo binding domain of KLC. | 2 |
Citation
Dessen P
KLC1 (kinesin light chain 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-12-01
Online version: http://atlasgeneticsoncology.org/gene/49869/klc1
