Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KLC1 (kinesin light chain 1)

Identity

Alias_namesKNS2
kinesin 2 60/70kDa
kinesin 2
Alias_symbol (synonym)KNS2A
KLC
hKLC1S
hKLC1N
hKLC1P
hKLC1G
hKLC1R
hKLC1J
hKLC1B
Other alias
HGNC (Hugo) KLC1
LocusID (NCBI) 3831
Atlas_Id 49869
Location 14q32.33  [Link to chromosome band 14q32]
Location_base_pair Starts at 103629188 and ends at 103701551 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CAPNS1 (19q13.12) / KLC1 (14q32.33)CDK6 (7q21.2) / KLC1 (14q32.33)FAM19A5 (22q13.32) / KLC1 (14q32.33)
KLC1 (14q32.33) / ALK (2p23.2)KLC1 (14q32.33) / APOPT1 (14q32.33)KLC1 (14q32.33) / EFCAB6 (22q13.2)
KLC1 (14q32.33) / KLC1 (14q32.33)KLC1 (14q32.33) / NBPF14 (1q21.2)KLC1 (14q32.33) / NECTIN1 (11q23.3)
KLC1 (14q32.33) / ZBED8 (5q33.3)KLC1 14q32.33 / ALK 2p23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)KLC1   6387
Cards
Entrez_Gene (NCBI)KLC1  3831  kinesin light chain 1
AliasesKLC; KNS2; KNS2A
GeneCards (Weizmann)KLC1
Ensembl hg19 (Hinxton)ENSG00000126214 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126214 [Gene_View]  chr14:103629188-103701551 [Contig_View]  KLC1 [Vega]
ICGC DataPortalENSG00000126214
TCGA cBioPortalKLC1
AceView (NCBI)KLC1
Genatlas (Paris)KLC1
WikiGenes3831
SOURCE (Princeton)KLC1
Genetics Home Reference (NIH)KLC1
Genomic and cartography
GoldenPath hg38 (UCSC)KLC1  -     chr14:103629188-103701551 +  14q32.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLC1  -     14q32.33   [Description]    (hg19-Feb_2009)
EnsemblKLC1 - 14q32.33 [CytoView hg19]  KLC1 - 14q32.33 [CytoView hg38]
Mapping of homologs : NCBIKLC1 [Mapview hg19]  KLC1 [Mapview hg38]
OMIM600025   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001130107 NM_005552 NM_182923
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLC1
Cluster EST : UnigeneHs.657678 [ NCBI ]
CGAP (NCI)Hs.657678
Alternative Splicing GalleryENSG00000126214
Gene ExpressionKLC1 [ NCBI-GEO ]   KLC1 [ EBI - ARRAY_EXPRESS ]   KLC1 [ SEEK ]   KLC1 [ MEM ]
Gene Expression Viewer (FireBrowse)KLC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3831
GTEX Portal (Tissue expression)KLC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07866   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07866  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07866
Splice isoforms : SwissVarQ07866
PhosPhoSitePlusQ07866
Domaine pattern : Prosite (Expaxy)KINESIN_LIGHT (PS01160)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Kinesin_light    Kinesin_light_repeat    TPR-contain_dom    TPR-like_helical_dom    TPR_repeat   
Domain families : Pfam (Sanger)TPR_10 (PF13374)   
Domain families : Pfam (NCBI)pfam13374   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)KLC1
DMDM Disease mutations3831
Blocks (Seattle)KLC1
PDB (SRS)3NF1   
PDB (PDBSum)3NF1   
PDB (IMB)3NF1   
PDB (RSDB)3NF1   
Structural Biology KnowledgeBase3NF1   
SCOP (Structural Classification of Proteins)3NF1   
CATH (Classification of proteins structures)3NF1   
SuperfamilyQ07866
Human Protein AtlasENSG00000126214
Peptide AtlasQ07866
HPRD02489
IPIIPI00020096   IPI00921532   IPI00412642   IPI00479424   IPI00337465   IPI00397666   IPI00398708   IPI00385431   IPI01009541   IPI01015701   IPI01025454   IPI01025408   IPI01026014   IPI01026112   IPI01025729   IPI01025874   IPI00472303   IPI01010793   IPI01015374   
Protein Interaction databases
DIP (DOE-UCLA)Q07866
IntAct (EBI)Q07866
FunCoupENSG00000126214
BioGRIDKLC1
STRING (EMBL)KLC1
ZODIACKLC1
Ontologies - Pathways
QuickGOQ07866
Ontology : AmiGOmotor activity  microtubule motor activity  protein binding  cytosol  cytosol  kinesin complex  microtubule  intracellular protein transport  retrograde vesicle-mediated transport, Golgi to ER  microtubule-based movement  tubulin binding  membrane  viral process  antigen processing and presentation of exogenous peptide antigen via MHC class II  axon  growth cone  cytoplasmic vesicle  protein localization to synapse  stress granule disassembly  neuronal cell body  
Ontology : EGO-EBImotor activity  microtubule motor activity  protein binding  cytosol  cytosol  kinesin complex  microtubule  intracellular protein transport  retrograde vesicle-mediated transport, Golgi to ER  microtubule-based movement  tubulin binding  membrane  viral process  antigen processing and presentation of exogenous peptide antigen via MHC class II  axon  growth cone  cytoplasmic vesicle  protein localization to synapse  stress granule disassembly  neuronal cell body  
Pathways : KEGGSalmonella infection   
NDEx NetworkKLC1
Atlas of Cancer Signalling NetworkKLC1
Wikipedia pathwaysKLC1
Orthology - Evolution
OrthoDB3831
GeneTree (enSembl)ENSG00000126214
Phylogenetic Trees/Animal Genes : TreeFamKLC1
HOVERGENQ07866
HOGENOMQ07866
Homologs : HomoloGeneKLC1
Homology/Alignments : Family Browser (UCSC)KLC1
Gene fusions - Rearrangements
Fusion : MitelmanKLC1/ALK [14q32.33/2p23.2]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLC1
dbVarKLC1
ClinVarKLC1
1000_GenomesKLC1 
Exome Variant ServerKLC1
ExAC (Exome Aggregation Consortium)KLC1 (select the gene name)
Genetic variants : HAPMAP3831
Genomic Variants (DGV)KLC1 [DGVbeta]
DECIPHERKLC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLC1 
Mutations
ICGC Data PortalKLC1 
TCGA Data PortalKLC1 
Broad Tumor PortalKLC1
OASIS PortalKLC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLC1
DgiDB (Drug Gene Interaction Database)KLC1
DoCM (Curated mutations)KLC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLC1 (select a term)
intoGenKLC1
Cancer3DKLC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600025   
Orphanet
MedgenKLC1
Genetic Testing Registry KLC1
NextProtQ07866 [Medical]
TSGene3831
GENETestsKLC1
Target ValidationKLC1
Huge Navigator KLC1 [HugePedia]
snp3D : Map Gene to Disease3831
BioCentury BCIQKLC1
ClinGenKLC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3831
Chemical/Pharm GKB GenePA162393424
Clinical trialKLC1
Miscellaneous
canSAR (ICR)KLC1 (select the gene name)
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLC1
EVEXKLC1
GoPubMedKLC1
iHOPKLC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:39:43 CEST 2017

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