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KLC2 (kinesin light chain 2)

Identity

Alias_symbol (synonym)FLJ12387
Other alias-
HGNC (Hugo) KLC2
LocusID (NCBI) 64837
Atlas_Id 55194
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 66257703 and ends at 66267861 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
COLQ (3p25.1) / KLC2 (11q13.2)LMF1 (16p13.3) / KLC2 (11q13.2)RSF1 (11q14.1) / KLC2 (11q13.2)
RSF1 11q14.1 / KLC2 11q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLC2   20716
Cards
Entrez_Gene (NCBI)KLC2  64837  kinesin light chain 2
Aliases
GeneCards (Weizmann)KLC2
Ensembl hg19 (Hinxton)ENSG00000174996 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174996 [Gene_View]  chr11:66257703-66267861 [Contig_View]  KLC2 [Vega]
ICGC DataPortalENSG00000174996
TCGA cBioPortalKLC2
AceView (NCBI)KLC2
Genatlas (Paris)KLC2
WikiGenes64837
SOURCE (Princeton)KLC2
Genetics Home Reference (NIH)KLC2
Genomic and cartography
GoldenPath hg38 (UCSC)KLC2  -     chr11:66257703-66267861 +  11q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLC2  -     11q13.2   [Description]    (hg19-Feb_2009)
EnsemblKLC2 - 11q13.2 [CytoView hg19]  KLC2 - 11q13.2 [CytoView hg38]
Mapping of homologs : NCBIKLC2 [Mapview hg19]  KLC2 [Mapview hg38]
OMIM609541   611729   
Gene and transcription
Genbank (Entrez)AK022449 AK022907 AK094593 AK126489 AK315725
RefSeq transcript (Entrez)NM_001134774 NM_001134775 NM_001134776 NM_001318734 NM_022822
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLC2
Cluster EST : UnigeneHs.280792 [ NCBI ]
CGAP (NCI)Hs.280792
Alternative Splicing GalleryENSG00000174996
Gene ExpressionKLC2 [ NCBI-GEO ]   KLC2 [ EBI - ARRAY_EXPRESS ]   KLC2 [ SEEK ]   KLC2 [ MEM ]
Gene Expression Viewer (FireBrowse)KLC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64837
GTEX Portal (Tissue expression)KLC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H0B6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H0B6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H0B6
Splice isoforms : SwissVarQ9H0B6
PhosPhoSitePlusQ9H0B6
Domaine pattern : Prosite (Expaxy)KINESIN_LIGHT (PS01160)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Kinesin_light    Kinesin_light_repeat    TPR-contain_dom    TPR-like_helical_dom    TPR_repeat   
Domain families : Pfam (Sanger)TPR_10 (PF13374)   
Domain families : Pfam (NCBI)pfam13374   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)KLC2
DMDM Disease mutations64837
Blocks (Seattle)KLC2
PDB (SRS)3CEQ    3EDT   
PDB (PDBSum)3CEQ    3EDT   
PDB (IMB)3CEQ    3EDT   
PDB (RSDB)3CEQ    3EDT   
Structural Biology KnowledgeBase3CEQ    3EDT   
SCOP (Structural Classification of Proteins)3CEQ    3EDT   
CATH (Classification of proteins structures)3CEQ    3EDT   
SuperfamilyQ9H0B6
Human Protein AtlasENSG00000174996
Peptide AtlasQ9H0B6
HPRD13917
IPIIPI00021634   IPI00983410   IPI00791952   IPI00793613   IPI00793175   IPI00887742   IPI00975670   IPI00981042   IPI00976346   IPI01010830   
Protein Interaction databases
DIP (DOE-UCLA)Q9H0B6
IntAct (EBI)Q9H0B6
FunCoupENSG00000174996
BioGRIDKLC2
STRING (EMBL)KLC2
ZODIACKLC2
Ontologies - Pathways
QuickGOQ9H0B6
Ontology : AmiGOmicrotubule motor activity  protein binding  cytosol  cytosol  kinesin complex  microtubule  retrograde vesicle-mediated transport, Golgi to ER  microtubule-based movement  membrane  kinesin I complex  antigen processing and presentation of exogenous peptide antigen via MHC class II  kinesin binding  protein complex  cadherin binding  
Ontology : EGO-EBImicrotubule motor activity  protein binding  cytosol  cytosol  kinesin complex  microtubule  retrograde vesicle-mediated transport, Golgi to ER  microtubule-based movement  membrane  kinesin I complex  antigen processing and presentation of exogenous peptide antigen via MHC class II  kinesin binding  protein complex  cadherin binding  
Pathways : KEGGSalmonella infection   
NDEx NetworkKLC2
Atlas of Cancer Signalling NetworkKLC2
Wikipedia pathwaysKLC2
Orthology - Evolution
OrthoDB64837
GeneTree (enSembl)ENSG00000174996
Phylogenetic Trees/Animal Genes : TreeFamKLC2
HOVERGENQ9H0B6
HOGENOMQ9H0B6
Homologs : HomoloGeneKLC2
Homology/Alignments : Family Browser (UCSC)KLC2
Gene fusions - Rearrangements
Fusion : MitelmanRSF1/KLC2 [11q14.1/11q13.2]  [t(11;11)(q13;q14)]  
Fusion: TCGARSF1 11q14.1 KLC2 11q13.2 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLC2
dbVarKLC2
ClinVarKLC2
1000_GenomesKLC2 
Exome Variant ServerKLC2
ExAC (Exome Aggregation Consortium)KLC2 (select the gene name)
Genetic variants : HAPMAP64837
Genomic Variants (DGV)KLC2 [DGVbeta]
DECIPHERKLC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLC2 
Mutations
ICGC Data PortalKLC2 
TCGA Data PortalKLC2 
Broad Tumor PortalKLC2
OASIS PortalKLC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLC2
DgiDB (Drug Gene Interaction Database)KLC2
DoCM (Curated mutations)KLC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLC2 (select a term)
intoGenKLC2
Cancer3DKLC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609541    611729   
Orphanet21722   
MedgenKLC2
Genetic Testing Registry KLC2
NextProtQ9H0B6 [Medical]
TSGene64837
GENETestsKLC2
Target ValidationKLC2
Huge Navigator KLC2 [HugePedia]
snp3D : Map Gene to Disease64837
BioCentury BCIQKLC2
ClinGenKLC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64837
Chemical/Pharm GKB GenePA142671587
Clinical trialKLC2
Miscellaneous
canSAR (ICR)KLC2 (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLC2
EVEXKLC2
GoPubMedKLC2
iHOPKLC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:57:08 CEST 2017

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