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KLC3 (kinesin light chain 3)

Identity

Alias_symbol (synonym)KLC2L
KNS2B
KLCt
Other aliasKLC2
HGNC (Hugo) KLC3
LocusID (NCBI) 147700
Atlas_Id 54414
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 45340740 and ends at 45351520 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PPP1R37 (19q13.32) / KLC3 (19q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)KLC3   20717
Cards
Entrez_Gene (NCBI)KLC3  147700  kinesin light chain 3
AliasesKLC2; KLC2L; KLCt; KNS2B
GeneCards (Weizmann)KLC3
Ensembl hg19 (Hinxton)ENSG00000104892 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104892 [Gene_View]  chr19:45340740-45351520 [Contig_View]  KLC3 [Vega]
ICGC DataPortalENSG00000104892
TCGA cBioPortalKLC3
AceView (NCBI)KLC3
Genatlas (Paris)KLC3
WikiGenes147700
SOURCE (Princeton)KLC3
Genetics Home Reference (NIH)KLC3
Genomic and cartography
GoldenPath hg38 (UCSC)KLC3  -     chr19:45340740-45351520 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLC3  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblKLC3 - 19q13.32 [CytoView hg19]  KLC3 - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBIKLC3 [Mapview hg19]  KLC3 [Mapview hg38]
OMIM601334   
Gene and transcription
Genbank (Entrez)AK092481 BC025318 BC062998 BC073841 BC126418
RefSeq transcript (Entrez)NM_145275 NM_177417
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLC3
Cluster EST : UnigeneHs.298079 [ NCBI ]
CGAP (NCI)Hs.298079
Alternative Splicing GalleryENSG00000104892
Gene ExpressionKLC3 [ NCBI-GEO ]   KLC3 [ EBI - ARRAY_EXPRESS ]   KLC3 [ SEEK ]   KLC3 [ MEM ]
Gene Expression Viewer (FireBrowse)KLC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)147700
GTEX Portal (Tissue expression)KLC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P597   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P597  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P597
Splice isoforms : SwissVarQ6P597
PhosPhoSitePlusQ6P597
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Kinesin_light    TPR-contain_dom    TPR-like_helical_dom    TPR_repeat   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)KLC3
DMDM Disease mutations147700
Blocks (Seattle)KLC3
SuperfamilyQ6P597
Human Protein AtlasENSG00000104892
Peptide AtlasQ6P597
HPRD03212
IPIIPI00478456   IPI00736469   IPI00465074   
Protein Interaction databases
DIP (DOE-UCLA)Q6P597
IntAct (EBI)Q6P597
FunCoupENSG00000104892
BioGRIDKLC3
STRING (EMBL)KLC3
ZODIACKLC3
Ontologies - Pathways
QuickGOQ6P597
Ontology : AmiGOmicrotubule motor activity  protein binding  cytoplasm  kinesin complex  microtubule  microtubule binding  axo-dendritic transport  kinesin binding  motile cilium  ciliary rootlet  neuron projection  
Ontology : EGO-EBImicrotubule motor activity  protein binding  cytoplasm  kinesin complex  microtubule  microtubule binding  axo-dendritic transport  kinesin binding  motile cilium  ciliary rootlet  neuron projection  
Pathways : KEGGSalmonella infection   
NDEx NetworkKLC3
Atlas of Cancer Signalling NetworkKLC3
Wikipedia pathwaysKLC3
Orthology - Evolution
OrthoDB147700
GeneTree (enSembl)ENSG00000104892
Phylogenetic Trees/Animal Genes : TreeFamKLC3
HOVERGENQ6P597
HOGENOMQ6P597
Homologs : HomoloGeneKLC3
Homology/Alignments : Family Browser (UCSC)KLC3
Gene fusions - Rearrangements
Fusion : MitelmanPPP1R37/KLC3 [19q13.32/19q13.32]  [del(19)(q13q13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLC3
dbVarKLC3
ClinVarKLC3
1000_GenomesKLC3 
Exome Variant ServerKLC3
ExAC (Exome Aggregation Consortium)KLC3 (select the gene name)
Genetic variants : HAPMAP147700
Genomic Variants (DGV)KLC3 [DGVbeta]
DECIPHERKLC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLC3 
Mutations
ICGC Data PortalKLC3 
TCGA Data PortalKLC3 
Broad Tumor PortalKLC3
OASIS PortalKLC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLC3
DgiDB (Drug Gene Interaction Database)KLC3
DoCM (Curated mutations)KLC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLC3 (select a term)
intoGenKLC3
Cancer3DKLC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601334   
Orphanet
MedgenKLC3
Genetic Testing Registry KLC3
NextProtQ6P597 [Medical]
TSGene147700
GENETestsKLC3
Target ValidationKLC3
Huge Navigator KLC3 [HugePedia]
snp3D : Map Gene to Disease147700
BioCentury BCIQKLC3
ClinGenKLC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD147700
Chemical/Pharm GKB GenePA142671588
Clinical trialKLC3
Miscellaneous
canSAR (ICR)KLC3 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLC3
EVEXKLC3
GoPubMedKLC3
iHOPKLC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:39:43 CEST 2017

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