KLC3 (kinesin light chain 3)

2014-08-01  

Identity

HGNC
KLC3
LOCATION
19q13.32
LOCUSID
147700
ALIAS
KLC2,KLC2L,KLCt,KNS2B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 147700
MIM: 601334
HGNC: 20717
Ensembl: ENSG00000104892

Variants:

dbSNP: 147700
ClinVar: 147700
TCGA: ENSG00000104892
COSMIC: KLC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104892ENST00000391946Q6P597
ENSG00000104892ENST00000391946A0A024R0V3
ENSG00000104892ENST00000470402Q6P597
ENSG00000104892ENST00000585434Q6P597
ENSG00000104892ENST00000589373K7EL76
ENSG00000104892ENST00000589837K7ENJ3
ENSG00000104892ENST00000590063K7ELP9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate KTN1REACTOMER-HSA-5625970
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131285527oxaliplatinChemicalClinicalAnnotationassociatedPD19434073, 21449681, 22026922, 22188361, 29662106
PA150595617platinumChemicalClinicalAnnotationassociatedPD19434073, 21449681, 22026922, 22188361, 29662106
PA164713176Platinum compoundsChemicalClinicalAnnotationassociatedPD19434073, 21449681, 22026922, 22188361, 29662106
PA444101Esophageal NeoplasmsDiseaseClinicalAnnotationassociatedPD19434073, 21449681, 22026922, 22188361, 29662106
PA444937MesotheliomaDiseaseClinicalAnnotationassociatedPD
PA445204Ovarian NeoplasmsDiseaseClinicalAnnotationassociatedPD19434073, 21449681, 22026922, 22188361, 29662106
PA445218Pancreatic NeoplasmsDiseaseClinicalAnnotationassociatedPD19434073, 21449681, 22026922, 22188361, 29662106
PA445601OsteosarcomaDiseaseClinicalAnnotationassociatedPD19434073, 21449681, 22026922, 22188361, 29662106
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD19434073, 21449681, 22026922, 22188361, 29662106
PA449014cisplatinChemicalClinicalAnnotationassociatedPD19434073, 21449681, 22026922, 22188361, 29662106
PA449748gemcitabineChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
252099982014Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins.41
113191352001Kinesin light-chain KLC3 expression in testis is restricted to spermatids.20
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
125942062003Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion.8
154645702004Rat kinesin light chain 3 associates with spermatid mitochondria.6

Citation

Dessen P

KLC3 (kinesin light chain 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54414/klc3