Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KLC4 (kinesin light chain 4)

Identity

Alias_namesKNSL8
kinesin-like 8
Alias_symbol (synonym)bA387M24.3
Other alias
HGNC (Hugo) KLC4
LocusID (NCBI) 89953
Atlas_Id 64945
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 43059857 and ends at 43075099 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CATSPERB (14q32.12) / KLC4 (6p21.1)KLC4 (6p21.1) / CTSS (1q21.3)KLC4 (6p21.1) / LCK (1p35.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLC4   21624
Cards
Entrez_Gene (NCBI)KLC4  89953  kinesin light chain 4
AliasesKNSL8; bA387M24.3
GeneCards (Weizmann)KLC4
Ensembl hg19 (Hinxton)ENSG00000137171 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137171 [Gene_View]  ENSG00000137171 [Sequence]  chr6:43059857-43075099 [Contig_View]  KLC4 [Vega]
ICGC DataPortalENSG00000137171
TCGA cBioPortalKLC4
AceView (NCBI)KLC4
Genatlas (Paris)KLC4
WikiGenes89953
SOURCE (Princeton)KLC4
Genetics Home Reference (NIH)KLC4
Genomic and cartography
GoldenPath hg38 (UCSC)KLC4  -     chr6:43059857-43075099 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLC4  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblKLC4 - 6p21.1 [CytoView hg19]  KLC4 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIKLC4 [Mapview hg19]  KLC4 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK055293 AK056393 AK094102 AK127018 AK127894
RefSeq transcript (Entrez)NM_001289034 NM_001289035 NM_138343 NM_201521 NM_201522 NM_201523
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLC4
Cluster EST : UnigeneHs.655123 [ NCBI ]
CGAP (NCI)Hs.655123
Alternative Splicing GalleryENSG00000137171
Gene ExpressionKLC4 [ NCBI-GEO ]   KLC4 [ EBI - ARRAY_EXPRESS ]   KLC4 [ SEEK ]   KLC4 [ MEM ]
Gene Expression Viewer (FireBrowse)KLC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89953
GTEX Portal (Tissue expression)KLC4
Human Protein AtlasENSG00000137171-KLC4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NSK0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NSK0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NSK0
Splice isoforms : SwissVarQ9NSK0
PhosPhoSitePlusQ9NSK0
Domaine pattern : Prosite (Expaxy)KINESIN_LIGHT (PS01160)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Kinesin_light    Kinesin_light_repeat    TPR-contain_dom    TPR-like_helical_dom    TPR_repeat   
Domain families : Pfam (Sanger)TPR_10 (PF13374)   
Domain families : Pfam (NCBI)pfam13374   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)KLC4
DMDM Disease mutations89953
Blocks (Seattle)KLC4
SuperfamilyQ9NSK0
Human Protein Atlas [tissue]ENSG00000137171-KLC4 [tissue]
Peptide AtlasQ9NSK0
HPRD13932
IPIIPI00398812   IPI00788630   IPI00743879   IPI00909371   IPI00061476   IPI00946172   IPI00945157   IPI00947288   IPI00947002   IPI00945465   IPI00946029   IPI00946215   
Protein Interaction databases
DIP (DOE-UCLA)Q9NSK0
IntAct (EBI)Q9NSK0
FunCoupENSG00000137171
BioGRIDKLC4
STRING (EMBL)KLC4
ZODIACKLC4
Ontologies - Pathways
QuickGOQ9NSK0
Ontology : AmiGOmicrotubule motor activity  protein binding  cytoplasm  kinesin complex  microtubule  
Ontology : EGO-EBImicrotubule motor activity  protein binding  cytoplasm  kinesin complex  microtubule  
NDEx NetworkKLC4
Atlas of Cancer Signalling NetworkKLC4
Wikipedia pathwaysKLC4
Orthology - Evolution
OrthoDB89953
GeneTree (enSembl)ENSG00000137171
Phylogenetic Trees/Animal Genes : TreeFamKLC4
HOVERGENQ9NSK0
HOGENOMQ9NSK0
Homologs : HomoloGeneKLC4
Homology/Alignments : Family Browser (UCSC)KLC4
Gene fusions - Rearrangements
Fusion : QuiverKLC4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLC4
dbVarKLC4
ClinVarKLC4
1000_GenomesKLC4 
Exome Variant ServerKLC4
ExAC (Exome Aggregation Consortium)ENSG00000137171
GNOMAD BrowserENSG00000137171
Varsome BrowserKLC4
Genetic variants : HAPMAP89953
Genomic Variants (DGV)KLC4 [DGVbeta]
DECIPHERKLC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLC4 
Mutations
ICGC Data PortalKLC4 
TCGA Data PortalKLC4 
Broad Tumor PortalKLC4
OASIS PortalKLC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLC4
DgiDB (Drug Gene Interaction Database)KLC4
DoCM (Curated mutations)KLC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLC4 (select a term)
intoGenKLC4
Cancer3DKLC4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETKLC4
MedgenKLC4
Genetic Testing Registry KLC4
NextProtQ9NSK0 [Medical]
TSGene89953
GENETestsKLC4
Target ValidationKLC4
Huge Navigator KLC4 [HugePedia]
snp3D : Map Gene to Disease89953
BioCentury BCIQKLC4
ClinGenKLC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD89953
Chemical/Pharm GKB GenePA134934134
Clinical trialKLC4
Miscellaneous
canSAR (ICR)KLC4 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLC4
EVEXKLC4
GoPubMedKLC4
iHOPKLC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 13:51:06 CEST 2018

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