KLF10 (Kruppel like factor 10)

2006-10-01  

Identity

HGNC
LOCATION
8q22.3
LOCUSID
ALIAS
EGR-alpha,EGRA,TIEG,TIEG1
FUSION GENES

Other Information

Locus ID:

NCBI: 7071
MIM: 601878
HGNC: 11810
Ensembl: ENSG00000155090

Variants:

dbSNP: 7071
ClinVar: 7071
TCGA: ENSG00000155090
COSMIC: KLF10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155090ENST00000285407Q13118
ENSG00000155090ENST00000395884Q13118

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
121730492002TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.57
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
200878942010Functional role of KLF10 in multiple disease processes.30
183592872008Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors.29
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
208638142010Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10.23
220256752012TIEG1 inhibits breast cancer invasion and metastasis by inhibition of epidermal growth factor receptor (EGFR) transcription and the EGFR signaling pathway.22
184831782008Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain.21
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20

Citation

Dessen P

KLF10 (Kruppel like factor 10)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43564/klf10