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KLF10 (Kruppel like factor 10)

Identity

Alias_namesTIEG
TGFB inducible early growth response
Alias_symbol (synonym)EGRA
TIEG1
Other aliasEGR-alpha
HGNC (Hugo) KLF10
LocusID (NCBI) 7071
Atlas_Id 43564
Location 8q22.3  [Link to chromosome band 8q22]
Location_base_pair Starts at 102648777 and ends at 102653964 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGEF7 (13q34) / KLF10 (8q22.3)ARHGEF7 13q34 / KLF10 8q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLF10   11810
LRG (Locus Reference Genomic)LRG_758
Cards
Entrez_Gene (NCBI)KLF10  7071  Kruppel like factor 10
AliasesEGR-alpha; EGRA; TIEG; TIEG1
GeneCards (Weizmann)KLF10
Ensembl hg19 (Hinxton)ENSG00000155090 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155090 [Gene_View]  chr8:102648777-102653964 [Contig_View]  KLF10 [Vega]
ICGC DataPortalENSG00000155090
TCGA cBioPortalKLF10
AceView (NCBI)KLF10
Genatlas (Paris)KLF10
WikiGenes7071
SOURCE (Princeton)KLF10
Genetics Home Reference (NIH)KLF10
Genomic and cartography
GoldenPath hg38 (UCSC)KLF10  -     chr8:102648777-102653964 -  8q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLF10  -     8q22.3   [Description]    (hg19-Feb_2009)
EnsemblKLF10 - 8q22.3 [CytoView hg19]  KLF10 - 8q22.3 [CytoView hg38]
Mapping of homologs : NCBIKLF10 [Mapview hg19]  KLF10 [Mapview hg38]
OMIM601878   
Gene and transcription
Genbank (Entrez)AK312894 BC011538 BC095399 BI560615 BQ575313
RefSeq transcript (Entrez)NM_001032282 NM_005655
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLF10
Cluster EST : UnigeneHs.435001 [ NCBI ]
CGAP (NCI)Hs.435001
Alternative Splicing GalleryENSG00000155090
Gene ExpressionKLF10 [ NCBI-GEO ]   KLF10 [ EBI - ARRAY_EXPRESS ]   KLF10 [ SEEK ]   KLF10 [ MEM ]
Gene Expression Viewer (FireBrowse)KLF10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7071
GTEX Portal (Tissue expression)KLF10
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13118   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13118  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13118
Splice isoforms : SwissVarQ13118
PhosPhoSitePlusQ13118
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)KLF10
DMDM Disease mutations7071
Blocks (Seattle)KLF10
PDB (SRS)2EPA   
PDB (PDBSum)2EPA   
PDB (IMB)2EPA   
PDB (RSDB)2EPA   
Structural Biology KnowledgeBase2EPA   
SCOP (Structural Classification of Proteins)2EPA   
CATH (Classification of proteins structures)2EPA   
SuperfamilyQ13118
Human Protein AtlasENSG00000155090
Peptide AtlasQ13118
HPRD03527
IPIIPI00011863   IPI00651766   
Protein Interaction databases
DIP (DOE-UCLA)Q13118
IntAct (EBI)Q13118
FunCoupENSG00000155090
BioGRIDKLF10
STRING (EMBL)KLF10
ZODIACKLF10
Ontologies - Pathways
QuickGOQ13118
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  core promoter sequence-specific DNA binding  skeletal system development  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  transcription, DNA-templated  transforming growth factor beta receptor signaling pathway  cell-cell signaling  circadian rhythm  cell proliferation  negative regulation of cell proliferation  cellular response to starvation  bone mineralization  somatic stem cell population maintenance  regulation of circadian rhythm  positive regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  metal ion binding  cellular response to peptide  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  core promoter sequence-specific DNA binding  skeletal system development  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  transcription, DNA-templated  transforming growth factor beta receptor signaling pathway  cell-cell signaling  circadian rhythm  cell proliferation  negative regulation of cell proliferation  cellular response to starvation  bone mineralization  somatic stem cell population maintenance  regulation of circadian rhythm  positive regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  metal ion binding  cellular response to peptide  
NDEx NetworkKLF10
Atlas of Cancer Signalling NetworkKLF10
Wikipedia pathwaysKLF10
Orthology - Evolution
OrthoDB7071
GeneTree (enSembl)ENSG00000155090
Phylogenetic Trees/Animal Genes : TreeFamKLF10
HOVERGENQ13118
HOGENOMQ13118
Homologs : HomoloGeneKLF10
Homology/Alignments : Family Browser (UCSC)KLF10
Gene fusions - Rearrangements
Fusion : MitelmanARHGEF7/KLF10 [13q34/8q22.3]  [t(8;13)(q22;q34)]  
Fusion: TCGAARHGEF7 13q34 KLF10 8q22.3 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLF10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLF10
dbVarKLF10
ClinVarKLF10
1000_GenomesKLF10 
Exome Variant ServerKLF10
ExAC (Exome Aggregation Consortium)KLF10 (select the gene name)
Genetic variants : HAPMAP7071
Genomic Variants (DGV)KLF10 [DGVbeta]
DECIPHERKLF10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLF10 
Mutations
ICGC Data PortalKLF10 
TCGA Data PortalKLF10 
Broad Tumor PortalKLF10
OASIS PortalKLF10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLF10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLF10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLF10
DgiDB (Drug Gene Interaction Database)KLF10
DoCM (Curated mutations)KLF10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLF10 (select a term)
intoGenKLF10
Cancer3DKLF10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601878   
Orphanet
MedgenKLF10
Genetic Testing Registry KLF10
NextProtQ13118 [Medical]
TSGene7071
GENETestsKLF10
Target ValidationKLF10
Huge Navigator KLF10 [HugePedia]
snp3D : Map Gene to Disease7071
BioCentury BCIQKLF10
ClinGenKLF10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7071
Chemical/Pharm GKB GenePA36517
Clinical trialKLF10
Miscellaneous
canSAR (ICR)KLF10 (select the gene name)
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLF10
EVEXKLF10
GoPubMedKLF10
iHOPKLF10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:14:37 CEST 2017

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