Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KLF12 (Kruppel like factor 12)

Identity

Alias_symbol (synonym)AP-2rep
HSPC122
AP2REP
Other alias
HGNC (Hugo) KLF12
LocusID (NCBI) 11278
Atlas_Id 41073
Location 13q22.1  [Link to chromosome band 13q22]
Location_base_pair Starts at 73686012 and ends at 74133929 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CENPO (2p23.3) / KLF12 (13q22.1)FBXW7 (4q31.3) / KLF12 (13q22.1)KLF12 (13q22.1) / KLF12 (13q22.1)
SAR1B (5q31.1) / KLF12 (13q22.1)VPS41 (7p14.1) / KLF12 (13q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLF12   6346
Cards
Entrez_Gene (NCBI)KLF12  11278  Kruppel like factor 12
AliasesAP-2rep; AP2REP; HSPC122
GeneCards (Weizmann)KLF12
Ensembl hg19 (Hinxton)ENSG00000118922 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118922 [Gene_View]  chr13:73686012-74133929 [Contig_View]  KLF12 [Vega]
ICGC DataPortalENSG00000118922
TCGA cBioPortalKLF12
AceView (NCBI)KLF12
Genatlas (Paris)KLF12
WikiGenes11278
SOURCE (Princeton)KLF12
Genetics Home Reference (NIH)KLF12
Genomic and cartography
GoldenPath hg38 (UCSC)KLF12  -     chr13:73686012-74133929 -  13q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLF12  -     13q22.1   [Description]    (hg19-Feb_2009)
EnsemblKLF12 - 13q22.1 [CytoView hg19]  KLF12 - 13q22.1 [CytoView hg38]
Mapping of homologs : NCBIKLF12 [Mapview hg19]  KLF12 [Mapview hg38]
OMIM607531   
Gene and transcription
Genbank (Entrez)AF113122 AF161471 AF330041 AI949908 AJ243274
RefSeq transcript (Entrez)NM_007249 NM_016285
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLF12
Cluster EST : UnigeneHs.729350 [ NCBI ]
CGAP (NCI)Hs.729350
Alternative Splicing GalleryENSG00000118922
Gene ExpressionKLF12 [ NCBI-GEO ]   KLF12 [ EBI - ARRAY_EXPRESS ]   KLF12 [ SEEK ]   KLF12 [ MEM ]
Gene Expression Viewer (FireBrowse)KLF12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11278
GTEX Portal (Tissue expression)KLF12
Human Protein AtlasENSG00000118922-KLF12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4X4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4X4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4X4
Splice isoforms : SwissVarQ9Y4X4
PhosPhoSitePlusQ9Y4X4
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam00096   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)KLF12
DMDM Disease mutations11278
Blocks (Seattle)KLF12
SuperfamilyQ9Y4X4
Human Protein Atlas [tissue]ENSG00000118922-KLF12 [tissue]
Peptide AtlasQ9Y4X4
HPRD06336
IPIIPI00027024   IPI00239722   IPI00940701   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4X4
IntAct (EBI)Q9Y4X4
FunCoupENSG00000118922
BioGRIDKLF12
STRING (EMBL)KLF12
ZODIACKLF12
Ontologies - Pathways
QuickGOQ9Y4X4
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleoplasm  cytosol  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleoplasm  cytosol  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  
NDEx NetworkKLF12
Atlas of Cancer Signalling NetworkKLF12
Wikipedia pathwaysKLF12
Orthology - Evolution
OrthoDB11278
GeneTree (enSembl)ENSG00000118922
Phylogenetic Trees/Animal Genes : TreeFamKLF12
HOVERGENQ9Y4X4
HOGENOMQ9Y4X4
Homologs : HomoloGeneKLF12
Homology/Alignments : Family Browser (UCSC)KLF12
Gene fusions - Rearrangements
Tumor Fusion PortalKLF12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLF12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLF12
dbVarKLF12
ClinVarKLF12
1000_GenomesKLF12 
Exome Variant ServerKLF12
ExAC (Exome Aggregation Consortium)ENSG00000118922
GNOMAD BrowserENSG00000118922
Genetic variants : HAPMAP11278
Genomic Variants (DGV)KLF12 [DGVbeta]
DECIPHERKLF12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLF12 
Mutations
ICGC Data PortalKLF12 
TCGA Data PortalKLF12 
Broad Tumor PortalKLF12
OASIS PortalKLF12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLF12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLF12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLF12
DgiDB (Drug Gene Interaction Database)KLF12
DoCM (Curated mutations)KLF12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLF12 (select a term)
intoGenKLF12
Cancer3DKLF12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607531   
Orphanet
DisGeNETKLF12
MedgenKLF12
Genetic Testing Registry KLF12
NextProtQ9Y4X4 [Medical]
TSGene11278
GENETestsKLF12
Target ValidationKLF12
Huge Navigator KLF12 [HugePedia]
snp3D : Map Gene to Disease11278
BioCentury BCIQKLF12
ClinGenKLF12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11278
Chemical/Pharm GKB GenePA30132
Clinical trialKLF12
Miscellaneous
canSAR (ICR)KLF12 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLF12
EVEXKLF12
GoPubMedKLF12
iHOPKLF12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:19:04 CET 2017

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