KLF14 (Kruppel like factor 14)

2016-05-01 Affiliation

Identity

HGNC

KLF14

LOCATION

7q32.2

LOCUSID

136259

ALIAS

BTEB5

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 136259
MIM: 609393
HGNC: 23025
Ensembl: ENSG00000266265

Variants:

dbSNP: 136259
ClinVar: 136259
TCGA: ENSG00000266265
COSMIC: KLF14

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000266265	ENST00000583337	Q8TD94

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19936222	2009	Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.	151
21572415	2011	Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.	145
19578363	2009	New common variants affecting susceptibility to basal cell carcinoma.	135
20889853	2011	Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.	65
17480121	2007	Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution.	40
19088080	2009	Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling.	24
26439168	2015	Loss of KLF14 triggers centrosome amplification and tumorigenesis.	21
29632379	2018	Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.	21
26368306	2015	Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.	19
24759103	2014	New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids.	18

Citation

Dessen P

KLF14 (Kruppel like factor 14)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55760/klf14