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KLF2 (Kruppel like factor 2)

Identity

Alias_namesKruppel-like factor 2 (lung)
Alias_symbol (synonym)LKLF
Other alias
HGNC (Hugo) KLF2
LocusID (NCBI) 10365
Atlas_Id 51504
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 16324826 and ends at 16328662 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C19orf25 (19p13.3) / KLF2 (19p13.11)RPPH1 (14q11.2) / KLF2 (19p13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLF2   6347
Cards
Entrez_Gene (NCBI)KLF2  10365  Kruppel like factor 2
AliasesLKLF
GeneCards (Weizmann)KLF2
Ensembl hg19 (Hinxton)ENSG00000127528 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127528 [Gene_View]  chr19:16324826-16328662 [Contig_View]  KLF2 [Vega]
ICGC DataPortalENSG00000127528
TCGA cBioPortalKLF2
AceView (NCBI)KLF2
Genatlas (Paris)KLF2
WikiGenes10365
SOURCE (Princeton)KLF2
Genetics Home Reference (NIH)KLF2
Genomic and cartography
GoldenPath hg38 (UCSC)KLF2  -     chr19:16324826-16328662 +  19p13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLF2  -     19p13.11   [Description]    (hg19-Feb_2009)
EnsemblKLF2 - 19p13.11 [CytoView hg19]  KLF2 - 19p13.11 [CytoView hg38]
Mapping of homologs : NCBIKLF2 [Mapview hg19]  KLF2 [Mapview hg38]
OMIM602016   
Gene and transcription
Genbank (Entrez)AF134053 AF205849 AK225820 BC035342 BC071983
RefSeq transcript (Entrez)NM_016270
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLF2
Cluster EST : UnigeneHs.744182 [ NCBI ]
CGAP (NCI)Hs.744182
Alternative Splicing GalleryENSG00000127528
Gene ExpressionKLF2 [ NCBI-GEO ]   KLF2 [ EBI - ARRAY_EXPRESS ]   KLF2 [ SEEK ]   KLF2 [ MEM ]
Gene Expression Viewer (FireBrowse)KLF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10365
GTEX Portal (Tissue expression)KLF2
Human Protein AtlasENSG00000127528-KLF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5W3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5W3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5W3
Splice isoforms : SwissVarQ9Y5W3
PhosPhoSitePlusQ9Y5W3
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam00096   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)KLF2
DMDM Disease mutations10365
Blocks (Seattle)KLF2
SuperfamilyQ9Y5W3
Human Protein Atlas [tissue]ENSG00000127528-KLF2 [tissue]
Peptide AtlasQ9Y5W3
HPRD03602
IPIIPI00001862   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5W3
IntAct (EBI)Q9Y5W3
FunCoupENSG00000127528
BioGRIDKLF2
STRING (EMBL)KLF2
ZODIACKLF2
Ontologies - Pathways
QuickGOQ9Y5W3
Ontology : AmiGOnuclear chromatin  cell morphogenesis  RNA polymerase II transcription factor activity, sequence-specific DNA binding  in utero embryonic development  DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  transcription, DNA-templated  negative regulation of interleukin-6 production  multicellular organism growth  positive regulation of transcription from RNA polymerase II promoter in response to stress  regulation of gene expression, epigenetic  erythrocyte maturation  sequence-specific DNA binding  positive regulation of nitric oxide biosynthetic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of protein metabolic process  Type I pneumocyte differentiation  cellular response to hydrogen peroxide  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to cycloheximide  cellular response to fluid shear stress  cellular response to laminar fluid shear stress  cellular response to peptide  
Ontology : EGO-EBInuclear chromatin  cell morphogenesis  RNA polymerase II transcription factor activity, sequence-specific DNA binding  in utero embryonic development  DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  transcription, DNA-templated  negative regulation of interleukin-6 production  multicellular organism growth  positive regulation of transcription from RNA polymerase II promoter in response to stress  regulation of gene expression, epigenetic  erythrocyte maturation  sequence-specific DNA binding  positive regulation of nitric oxide biosynthetic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of protein metabolic process  Type I pneumocyte differentiation  cellular response to hydrogen peroxide  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to cycloheximide  cellular response to fluid shear stress  cellular response to laminar fluid shear stress  cellular response to peptide  
Pathways : KEGGFoxO signaling pathway   
NDEx NetworkKLF2
Atlas of Cancer Signalling NetworkKLF2
Wikipedia pathwaysKLF2
Orthology - Evolution
OrthoDB10365
GeneTree (enSembl)ENSG00000127528
Phylogenetic Trees/Animal Genes : TreeFamKLF2
HOVERGENQ9Y5W3
HOGENOMQ9Y5W3
Homologs : HomoloGeneKLF2
Homology/Alignments : Family Browser (UCSC)KLF2
Gene fusions - Rearrangements
Tumor Fusion PortalKLF2
Fusion Cancer (Beijing)RPPH1 [14q11.2]  -  KLF2 [19p13.11]  [FUSC001385]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLF2
dbVarKLF2
ClinVarKLF2
1000_GenomesKLF2 
Exome Variant ServerKLF2
ExAC (Exome Aggregation Consortium)ENSG00000127528
GNOMAD BrowserENSG00000127528
Genetic variants : HAPMAP10365
Genomic Variants (DGV)KLF2 [DGVbeta]
DECIPHERKLF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLF2 
Mutations
ICGC Data PortalKLF2 
TCGA Data PortalKLF2 
Broad Tumor PortalKLF2
OASIS PortalKLF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLF2
DgiDB (Drug Gene Interaction Database)KLF2
DoCM (Curated mutations)KLF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLF2 (select a term)
intoGenKLF2
Cancer3DKLF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602016   
Orphanet
DisGeNETKLF2
MedgenKLF2
Genetic Testing Registry KLF2
NextProtQ9Y5W3 [Medical]
TSGene10365
GENETestsKLF2
Target ValidationKLF2
Huge Navigator KLF2 [HugePedia]
snp3D : Map Gene to Disease10365
BioCentury BCIQKLF2
ClinGenKLF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10365
Chemical/Pharm GKB GenePA30136
Clinical trialKLF2
Miscellaneous
canSAR (ICR)KLF2 (select the gene name)
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLF2
EVEXKLF2
GoPubMedKLF2
iHOPKLF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 21 14:19:05 CET 2017

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