KLF2 (Kruppel like factor 2)

2010-06-01  

Identity

HGNC
KLF2
LOCATION
19p13.11
LOCUSID
10365
ALIAS
LKLF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10365
MIM: 602016
HGNC: 6347
Ensembl: ENSG00000127528

Variants:

dbSNP: 10365
ClinVar: 10365
TCGA: ENSG00000127528
COSMIC: KLF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127528ENST00000248071Q9Y5W3
ENSG00000127528ENST00000592003K7EJ60

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
FoxO signaling pathwayKEGGhsa04068
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
223273662012Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.393
163412642006Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2.220
151365912004KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.214
121768892002Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2).202
255047552015Long noncoding RNA ANRIL promotes non-small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 expression.131
157184982005Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function.128
164559542006KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium.115
160436422005Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells.103
217685382011Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a.101
257286772015SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer.98

Citation

Dessen P

KLF2 (Kruppel like factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51504/klf2