KLHL21 (kelch like family member 21)

2003-05-01  

Identity

HGNC
LOCATION
1p36.31
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 9903
MIM: 616262
HGNC: 29041
Ensembl: ENSG00000162413

Variants:

dbSNP: 9903
ClinVar: 9903
TCGA: ENSG00000162413
COSMIC: KLHL21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162413ENST00000377658Q9UJP4
ENSG00000162413ENST00000377663Q9UJP4
ENSG00000162413ENST00000463043K7EMF2
ENSG00000162413ENST00000467612K7ELI0
ENSG00000162413ENST00000496707K7ESH2
ENSG00000162413ENST00000610898Q2NKK7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199959372009The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.48
277692512016KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma.13
273875022016Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.3
295741532018Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation.2

Citation

Dessen P

KLHL21 (kelch like family member 21)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41059/klhl21