Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KLHL21 (kelch like family member 21)

Identity

HGNC (Hugo) KLHL21
LocusID (NCBI) 9903
Atlas_Id 41059
Location 1p36.31
Location_base_pair Starts at 6650784 and ends at 6662958 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACOT7 (1p36.31) / KLHL21 (1p36.31)AZGP1 (7q22.1) / KLHL21 (1p36.31)KLHL21 (1p36.31) / KLHL21 (1p36.31)
ACOT7 1p36.31 / KLHL21 1p36.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLHL21   29041
Cards
Entrez_Gene (NCBI)KLHL21  9903  kelch like family member 21
GeneCards (Weizmann)KLHL21
Ensembl hg19 (Hinxton)ENSG00000162413 [Gene_View]  chr1:6650784-6662958 [Contig_View]  KLHL21 [Vega]
Ensembl hg38 (Hinxton)ENSG00000162413 [Gene_View]  chr1:6650784-6662958 [Contig_View]  KLHL21 [Vega]
ICGC DataPortalENSG00000162413
TCGA cBioPortalKLHL21
AceView (NCBI)KLHL21
Genatlas (Paris)KLHL21
WikiGenes9903
SOURCE (Princeton)KLHL21
Genomic and cartography
GoldenPath hg19 (UCSC)KLHL21  -     chr1:6650784-6662958 -  1p36.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KLHL21  -     1p36.31   [Description]    (hg38-Dec_2013)
EnsemblKLHL21 - 1p36.31 [CytoView hg19]  KLHL21 - 1p36.31 [CytoView hg38]
Mapping of homologs : NCBIKLHL21 [Mapview hg19]  KLHL21 [Mapview hg38]
OMIM616262   
Gene and transcription
Genbank (Entrez)AB007938 AK057164 AK075305 AK090472 AK307564
RefSeq transcript (Entrez)NM_014851
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)KLHL21
Cluster EST : UnigeneHs.7764 [ NCBI ]
CGAP (NCI)Hs.7764
Alternative Splicing : Fast-db (Paris)GSHG0001716
Alternative Splicing GalleryENSG00000162413
Gene ExpressionKLHL21 [ NCBI-GEO ]   KLHL21 [ EBI - ARRAY_EXPRESS ]   KLHL21 [ SEEK ]   KLHL21 [ MEM ]
Gene Expression Viewer (FireBrowse)KLHL21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)9903
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJP4 (Uniprot)
NextProtQ9UJP4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJP4
Splice isoforms : SwissVarQ9UJP4 (Swissvar)
PhosPhoSitePlusQ9UJP4
Domaine pattern : Prosite (Expaxy)BTB (PS50097)   
Domains : Interpro (EBI)BACK    BTB-kelch_protein    BTB/POZ_dom    Gal_Oxidase_b-propeller    Kelch_1    SKP1/BTB/POZ   
Domain families : Pfam (Sanger)BACK (PF07707)    BTB (PF00651)    Kelch_1 (PF01344)   
Domain families : Pfam (NCBI)pfam07707    pfam00651    pfam01344   
Domain families : Smart (EMBL)BACK (SM00875)  BTB (SM00225)  Kelch (SM00612)  
DMDM Disease mutations9903
Blocks (Seattle)KLHL21
SuperfamilyQ9UJP4
Human Protein AtlasENSG00000162413
Peptide AtlasQ9UJP4
HPRD17239
IPIIPI00402021   IPI00006994   IPI01009309   
Protein Interaction databases
DIP (DOE-UCLA)Q9UJP4
IntAct (EBI)Q9UJP4
FunCoupENSG00000162413
BioGRIDKLHL21
STRING (EMBL)KLHL21
ZODIACKLHL21
Ontologies - Pathways
QuickGOQ9UJP4
Ontology : AmiGOubiquitin-protein transferase activity  cytoplasm  centrosome  polar microtubule  mitotic nuclear division  protein ubiquitination  Cul3-RING ubiquitin ligase complex  regulation of cytokinesis  chromosome passenger complex localization to spindle midzone  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  cell division  
Ontology : EGO-EBIubiquitin-protein transferase activity  cytoplasm  centrosome  polar microtubule  mitotic nuclear division  protein ubiquitination  Cul3-RING ubiquitin ligase complex  regulation of cytokinesis  chromosome passenger complex localization to spindle midzone  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  cell division  
NDEx Network
Atlas of Cancer Signalling NetworkKLHL21
Wikipedia pathwaysKLHL21
Orthology - Evolution
OrthoDB9903
GeneTree (enSembl)ENSG00000162413
Phylogenetic Trees/Animal Genes : TreeFamKLHL21
Homologs : HomoloGeneKLHL21
Homology/Alignments : Family Browser (UCSC)KLHL21
Gene fusions - Rearrangements
Fusion: TCGAACOT7 1p36.31 KLHL21 1p36.31 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerKLHL21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLHL21
dbVarKLHL21
ClinVarKLHL21
1000_GenomesKLHL21 
Exome Variant ServerKLHL21
ExAC (Exome Aggregation Consortium)KLHL21 (select the gene name)
SNP (GeneSNP Utah)KLHL21
SNP : HGBaseKLHL21
Genetic variants : HAPMAPKLHL21
Genomic Variants (DGV)KLHL21 [DGVbeta]
Mutations
ICGC Data PortalKLHL21 
TCGA Data PortalKLHL21 
Broad Tumor PortalKLHL21
OASIS PortalKLHL21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLHL21 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLHL21
DgiDB (Drug Gene Interaction Database)KLHL21
DoCM (Curated mutations)KLHL21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLHL21 (select a term)
intoGenKLHL21
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:6650784-6662958
CONAN: Copy Number AnalysisKLHL21 
Mutations and Diseases : HGMDKLHL21
OMIM616262   
MedgenKLHL21
Genetic Testing Registry KLHL21
NextProtQ9UJP4 [Medical]
TSGene9903
GENETestsKLHL21
Huge Navigator KLHL21 [HugePedia]  KLHL21 [HugeCancerGEM]
snp3D : Map Gene to Disease9903
BioCentury BCIQKLHL21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9903
Chemical/Pharm GKB GenePA134989246
Clinical trialKLHL21
Miscellaneous
canSAR (ICR)KLHL21 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLHL21
GoPubMedKLHL21
iHOPKLHL21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 17:50:18 CEST 2016

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