Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KLHL4 (kelch-like family member 4)

Identity

Alias_nameskelch (Drosophila)-like 4
kelch-like 4 (Drosophila)
Alias_symbol (synonym)KIAA1687
DKELCHL
KHL4
Other alias
HGNC (Hugo) KLHL4
LocusID (NCBI) 56062
Atlas_Id 64981
Location Xq21.31  [Link to chromosome band Xq21]
Location_base_pair Starts at 86772715 and ends at 86925050 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CHM (Xq21.2) / KLHL4 (Xq21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLHL4   6355
Cards
Entrez_Gene (NCBI)KLHL4  56062  kelch-like family member 4
AliasesDKELCHL; KHL4
GeneCards (Weizmann)KLHL4
Ensembl hg19 (Hinxton)ENSG00000102271 [Gene_View]  chrX:86772715-86925050 [Contig_View]  KLHL4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000102271 [Gene_View]  chrX:86772715-86925050 [Contig_View]  KLHL4 [Vega]
ICGC DataPortalENSG00000102271
TCGA cBioPortalKLHL4
AceView (NCBI)KLHL4
Genatlas (Paris)KLHL4
WikiGenes56062
SOURCE (Princeton)KLHL4
Genetics Home Reference (NIH)KLHL4
Genomic and cartography
GoldenPath hg19 (UCSC)KLHL4  -     chrX:86772715-86925050 +  Xq21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KLHL4  -     Xq21.31   [Description]    (hg38-Dec_2013)
EnsemblKLHL4 - Xq21.31 [CytoView hg19]  KLHL4 - Xq21.31 [CytoView hg38]
Mapping of homologs : NCBIKLHL4 [Mapview hg19]  KLHL4 [Mapview hg38]
OMIM300348   
Gene and transcription
Genbank (Entrez)AB051474 AF284765 AF284766 AK022715 AK023057
RefSeq transcript (Entrez)NM_019117 NM_057162
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_012815 NT_011651 NW_004929444
Consensus coding sequences : CCDS (NCBI)KLHL4
Cluster EST : UnigeneHs.49075 [ NCBI ]
CGAP (NCI)Hs.49075
Alternative Splicing GalleryENSG00000102271
Gene ExpressionKLHL4 [ NCBI-GEO ]   KLHL4 [ EBI - ARRAY_EXPRESS ]   KLHL4 [ SEEK ]   KLHL4 [ MEM ]
Gene Expression Viewer (FireBrowse)KLHL4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56062
GTEX Portal (Tissue expression)KLHL4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C0H6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C0H6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C0H6
Splice isoforms : SwissVarQ9C0H6
PhosPhoSitePlusQ9C0H6
Domaine pattern : Prosite (Expaxy)BTB (PS50097)   
Domains : Interpro (EBI)BACK    BTB/POZ-like    BTB/POZ_fold    BTB_POZ    Gal_Oxidase_b-propeller    Kelch_1   
Domain families : Pfam (Sanger)BACK (PF07707)    BTB (PF00651)    Kelch_1 (PF01344)   
Domain families : Pfam (NCBI)pfam07707    pfam00651    pfam01344   
Domain families : Smart (EMBL)BACK (SM00875)  BTB (SM00225)  Kelch (SM00612)  
Conserved Domain (NCBI)KLHL4
DMDM Disease mutations56062
Blocks (Seattle)KLHL4
SuperfamilyQ9C0H6
Human Protein AtlasENSG00000102271
Peptide AtlasQ9C0H6
HPRD02283
IPIIPI00028464   IPI00219414   
Protein Interaction databases
DIP (DOE-UCLA)Q9C0H6
IntAct (EBI)Q9C0H6
FunCoupENSG00000102271
BioGRIDKLHL4
STRING (EMBL)KLHL4
ZODIACKLHL4
Ontologies - Pathways
QuickGOQ9C0H6
Ontology : AmiGOmolecular_function  actin binding  cytoplasm  cytoskeleton  biological_process  
Ontology : EGO-EBImolecular_function  actin binding  cytoplasm  cytoskeleton  biological_process  
NDEx NetworkKLHL4
Atlas of Cancer Signalling NetworkKLHL4
Wikipedia pathwaysKLHL4
Orthology - Evolution
OrthoDB56062
GeneTree (enSembl)ENSG00000102271
Phylogenetic Trees/Animal Genes : TreeFamKLHL4
HOVERGENQ9C0H6
HOGENOMQ9C0H6
Homologs : HomoloGeneKLHL4
Homology/Alignments : Family Browser (UCSC)KLHL4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLHL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLHL4
dbVarKLHL4
ClinVarKLHL4
1000_GenomesKLHL4 
Exome Variant ServerKLHL4
ExAC (Exome Aggregation Consortium)KLHL4 (select the gene name)
Genetic variants : HAPMAP56062
Genomic Variants (DGV)KLHL4 [DGVbeta]
DECIPHER (Syndromes)X:86772715-86925050  ENSG00000102271
CONAN: Copy Number AnalysisKLHL4 
Mutations
ICGC Data PortalKLHL4 
TCGA Data PortalKLHL4 
Broad Tumor PortalKLHL4
OASIS PortalKLHL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLHL4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLHL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch KLHL4
DgiDB (Drug Gene Interaction Database)KLHL4
DoCM (Curated mutations)KLHL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLHL4 (select a term)
intoGenKLHL4
Cancer3DKLHL4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300348   
Orphanet
MedgenKLHL4
Genetic Testing Registry KLHL4
NextProtQ9C0H6 [Medical]
TSGene56062
GENETestsKLHL4
Huge Navigator KLHL4 [HugePedia]
snp3D : Map Gene to Disease56062
BioCentury BCIQKLHL4
ClinGenKLHL4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56062
Chemical/Pharm GKB GenePA30145
Clinical trialKLHL4
Miscellaneous
canSAR (ICR)KLHL4 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLHL4
EVEXKLHL4
GoPubMedKLHL4
iHOPKLHL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:10:04 CET 2017

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