Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

KLHL42 (kelch like family member 42)

Identity

Alias_namesKLHDC5
kelch domain containing 5
Alias_symbol (synonym)KIAA1340
Ctb9
Other alias
HGNC (Hugo) KLHL42
LocusID (NCBI) 57542
Atlas_Id 64982
Location 12p11.22  [Link to chromosome band 12p11]
Location_base_pair Starts at 27780254 and ends at 27803040 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KLHL42 (12p11.22) / MRPS35 (12p11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLHL42   29252
Cards
Entrez_Gene (NCBI)KLHL42  57542  kelch like family member 42
AliasesCtb9; KLHDC5
GeneCards (Weizmann)KLHL42
Ensembl hg19 (Hinxton)ENSG00000087448 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000087448 [Gene_View]  chr12:27780254-27803040 [Contig_View]  KLHL42 [Vega]
ICGC DataPortalENSG00000087448
TCGA cBioPortalKLHL42
AceView (NCBI)KLHL42
Genatlas (Paris)KLHL42
WikiGenes57542
SOURCE (Princeton)KLHL42
Genetics Home Reference (NIH)KLHL42
Genomic and cartography
GoldenPath hg38 (UCSC)KLHL42  -     chr12:27780254-27803040 +  12p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLHL42  -     12p11.22   [Description]    (hg19-Feb_2009)
EnsemblKLHL42 - 12p11.22 [CytoView hg19]  KLHL42 - 12p11.22 [CytoView hg38]
Mapping of homologs : NCBIKLHL42 [Mapview hg19]  KLHL42 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA687307 AB037761 AK002197 AK095405 AL118635
RefSeq transcript (Entrez)NM_020782
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLHL42
Cluster EST : UnigeneHs.505104 [ NCBI ]
CGAP (NCI)Hs.505104
Alternative Splicing GalleryENSG00000087448
Gene ExpressionKLHL42 [ NCBI-GEO ]   KLHL42 [ EBI - ARRAY_EXPRESS ]   KLHL42 [ SEEK ]   KLHL42 [ MEM ]
Gene Expression Viewer (FireBrowse)KLHL42 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57542
GTEX Portal (Tissue expression)KLHL42
Human Protein AtlasENSG00000087448-KLHL42 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2K6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2K6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2K6
Splice isoforms : SwissVarQ9P2K6
PhosPhoSitePlusQ9P2K6
Domaine pattern : Prosite (Expaxy)BTB (PS50097)   
Domains : Interpro (EBI)BACK    BTB/POZ_dom    Kelch-typ_b-propeller    Kelch_1    SKP1/BTB/POZ   
Domain families : Pfam (Sanger)BACK (PF07707)    Kelch_1 (PF01344)   
Domain families : Pfam (NCBI)pfam07707    pfam01344   
Domain families : Smart (EMBL)Kelch (SM00612)  
Conserved Domain (NCBI)KLHL42
DMDM Disease mutations57542
Blocks (Seattle)KLHL42
SuperfamilyQ9P2K6
Human Protein Atlas [tissue]ENSG00000087448-KLHL42 [tissue]
Peptide AtlasQ9P2K6
HPRD17237
IPIIPI00220056   IPI01015643   IPI01016074   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2K6
IntAct (EBI)Q9P2K6
FunCoupENSG00000087448
BioGRIDKLHL42
STRING (EMBL)KLHL42
ZODIACKLHL42
Ontologies - Pathways
QuickGOQ9P2K6
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  protein binding  cytoplasm  spindle  cell cycle  Cul3-RING ubiquitin ligase complex  regulation of microtubule-based process  proteasome-mediated ubiquitin-dependent protein catabolic process  cell division  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  protein binding  cytoplasm  spindle  cell cycle  Cul3-RING ubiquitin ligase complex  regulation of microtubule-based process  proteasome-mediated ubiquitin-dependent protein catabolic process  cell division  
NDEx NetworkKLHL42
Atlas of Cancer Signalling NetworkKLHL42
Wikipedia pathwaysKLHL42
Orthology - Evolution
OrthoDB57542
GeneTree (enSembl)ENSG00000087448
Phylogenetic Trees/Animal Genes : TreeFamKLHL42
HOVERGENQ9P2K6
HOGENOMQ9P2K6
Homologs : HomoloGeneKLHL42
Homology/Alignments : Family Browser (UCSC)KLHL42
Gene fusions - Rearrangements
Tumor Fusion PortalKLHL42
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLHL42 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLHL42
dbVarKLHL42
ClinVarKLHL42
1000_GenomesKLHL42 
Exome Variant ServerKLHL42
ExAC (Exome Aggregation Consortium)ENSG00000087448
GNOMAD BrowserENSG00000087448
Genetic variants : HAPMAP57542
Genomic Variants (DGV)KLHL42 [DGVbeta]
DECIPHERKLHL42 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLHL42 
Mutations
ICGC Data PortalKLHL42 
TCGA Data PortalKLHL42 
Broad Tumor PortalKLHL42
OASIS PortalKLHL42 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDKLHL42
BioMutasearch KLHL42
DgiDB (Drug Gene Interaction Database)KLHL42
DoCM (Curated mutations)KLHL42 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLHL42 (select a term)
intoGenKLHL42
Cancer3DKLHL42(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETKLHL42
MedgenKLHL42
Genetic Testing Registry KLHL42
NextProtQ9P2K6 [Medical]
TSGene57542
GENETestsKLHL42
Target ValidationKLHL42
Huge Navigator KLHL42 [HugePedia]
snp3D : Map Gene to Disease57542
BioCentury BCIQKLHL42
ClinGenKLHL42
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57542
Chemical/Pharm GKB GenePA142671579
Clinical trialKLHL42
Miscellaneous
canSAR (ICR)KLHL42 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLHL42
EVEXKLHL42
GoPubMedKLHL42
iHOPKLHL42
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:26:20 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.