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KLHL5 (kelch like family member 5)

Identity

Alias_nameskelch (Drosophila)-like 5
kelch-like 5 (Drosophila)
Other alias-
HGNC (Hugo) KLHL5
LocusID (NCBI) 51088
Atlas_Id 64983
Location 4p14  [Link to chromosome band 4p14]
Location_base_pair Starts at 39044831 and ends at 39126233 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KLHL5 (4p14) / LNX1 (4q12)KLHL5 (4p14) / SLC16A2 (Xq13.2)KLHL5 LNX1
KLHL5 SLC16A2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLHL5   6356
Cards
Entrez_Gene (NCBI)KLHL5  51088  kelch like family member 5
Aliases
GeneCards (Weizmann)KLHL5
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr4:39044831-39126233 [Contig_View]  KLHL5 [Vega]
TCGA cBioPortalKLHL5
AceView (NCBI)KLHL5
Genatlas (Paris)KLHL5
WikiGenes51088
SOURCE (Princeton)KLHL5
Genetics Home Reference (NIH)KLHL5
Genomic and cartography
GoldenPath hg38 (UCSC)KLHL5  -     chr4:39044831-39126233 +  4p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLHL5  -     4p14   [Description]    (hg19-Feb_2009)
EnsemblKLHL5 - 4p14 [CytoView hg19]  KLHL5 - 4p14 [CytoView hg38]
Mapping of homologs : NCBIKLHL5 [Mapview hg19]  KLHL5 [Mapview hg38]
OMIM608064   
Gene and transcription
Genbank (Entrez)AA715102 AB208820 AF272976 AK001698 AK001836
RefSeq transcript (Entrez)NM_001007075 NM_001171654 NM_015990 NM_199039
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLHL5
Cluster EST : UnigeneHs.272251 [ NCBI ]
CGAP (NCI)Hs.272251
Gene ExpressionKLHL5 [ NCBI-GEO ]   KLHL5 [ EBI - ARRAY_EXPRESS ]   KLHL5 [ SEEK ]   KLHL5 [ MEM ]
Gene Expression Viewer (FireBrowse)KLHL5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51088
GTEX Portal (Tissue expression)KLHL5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PQ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PQ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PQ7
Splice isoforms : SwissVarQ96PQ7
PhosPhoSitePlusQ96PQ7
Domaine pattern : Prosite (Expaxy)BTB (PS50097)   
Domains : Interpro (EBI)BACK    BTB/POZ_dom    Gal_Oxidase_b-propeller    Kelch_1    SKP1/BTB/POZ   
Domain families : Pfam (Sanger)BACK (PF07707)    BTB (PF00651)    Kelch_1 (PF01344)   
Domain families : Pfam (NCBI)pfam07707    pfam00651    pfam01344   
Domain families : Smart (EMBL)BACK (SM00875)  BTB (SM00225)  Kelch (SM00612)  
Conserved Domain (NCBI)KLHL5
DMDM Disease mutations51088
Blocks (Seattle)KLHL5
SuperfamilyQ96PQ7
Peptide AtlasQ96PQ7
HPRD10477
IPIIPI00374862   IPI00374863   IPI00374866   IPI01011957   IPI00954821   IPI00883751   IPI00395429   IPI00871707   IPI00965087   IPI01012659   
Protein Interaction databases
DIP (DOE-UCLA)Q96PQ7
IntAct (EBI)Q96PQ7
BioGRIDKLHL5
STRING (EMBL)KLHL5
ZODIACKLHL5
Ontologies - Pathways
QuickGOQ96PQ7
Ontology : AmiGOmolecular_function  actin binding  ubiquitin-protein transferase activity  cytoplasm  cytoskeleton  biological_process  protein ubiquitination  Cul3-RING ubiquitin ligase complex  
Ontology : EGO-EBImolecular_function  actin binding  ubiquitin-protein transferase activity  cytoplasm  cytoskeleton  biological_process  protein ubiquitination  Cul3-RING ubiquitin ligase complex  
NDEx NetworkKLHL5
Atlas of Cancer Signalling NetworkKLHL5
Wikipedia pathwaysKLHL5
Orthology - Evolution
OrthoDB51088
Phylogenetic Trees/Animal Genes : TreeFamKLHL5
HOVERGENQ96PQ7
HOGENOMQ96PQ7
Homologs : HomoloGeneKLHL5
Homology/Alignments : Family Browser (UCSC)KLHL5
Gene fusions - Rearrangements
Fusion: TCGAKLHL5 LNX1
Fusion: TCGAKLHL5 SLC16A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLHL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLHL5
dbVarKLHL5
ClinVarKLHL5
1000_GenomesKLHL5 
Exome Variant ServerKLHL5
ExAC (Exome Aggregation Consortium)KLHL5 (select the gene name)
Genetic variants : HAPMAP51088
Genomic Variants (DGV)KLHL5 [DGVbeta]
DECIPHERKLHL5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLHL5 
Mutations
ICGC Data PortalKLHL5 
TCGA Data PortalKLHL5 
Broad Tumor PortalKLHL5
OASIS PortalKLHL5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLHL5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLHL5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLHL5
DgiDB (Drug Gene Interaction Database)KLHL5
DoCM (Curated mutations)KLHL5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLHL5 (select a term)
intoGenKLHL5
Cancer3DKLHL5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608064   
Orphanet
MedgenKLHL5
Genetic Testing Registry KLHL5
NextProtQ96PQ7 [Medical]
TSGene51088
GENETestsKLHL5
Target ValidationKLHL5
Huge Navigator KLHL5 [HugePedia]
snp3D : Map Gene to Disease51088
BioCentury BCIQKLHL5
ClinGenKLHL5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51088
Chemical/Pharm GKB GenePA30146
Clinical trialKLHL5
Miscellaneous
canSAR (ICR)KLHL5 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLHL5
EVEXKLHL5
GoPubMedKLHL5
iHOPKLHL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:54:50 CEST 2017

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