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KLHL6 (kelch like family member 6)

Identity

Alias_nameskelch-like 6 (Drosophila)
Alias_symbol (synonym)FLJ00029
Other alias-
HGNC (Hugo) KLHL6
LocusID (NCBI) 89857
Atlas_Id 64984
Location 3q27.1  [Link to chromosome band 3q27]
Location_base_pair Starts at 183487528 and ends at 183555712 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GLIPR2 (9p13.3) / KLHL6 (3q27.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLHL6   18653
Cards
Entrez_Gene (NCBI)KLHL6  89857  kelch like family member 6
Aliases
GeneCards (Weizmann)KLHL6
Ensembl hg19 (Hinxton)ENSG00000172578 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172578 [Gene_View]  chr3:183487528-183555712 [Contig_View]  KLHL6 [Vega]
ICGC DataPortalENSG00000172578
TCGA cBioPortalKLHL6
AceView (NCBI)KLHL6
Genatlas (Paris)KLHL6
WikiGenes89857
SOURCE (Princeton)KLHL6
Genetics Home Reference (NIH)KLHL6
Genomic and cartography
GoldenPath hg38 (UCSC)KLHL6  -     chr3:183487528-183555712 -  3q27.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLHL6  -     3q27.1   [Description]    (hg19-Feb_2009)
EnsemblKLHL6 - 3q27.1 [CytoView hg19]  KLHL6 - 3q27.1 [CytoView hg38]
Mapping of homologs : NCBIKLHL6 [Mapview hg19]  KLHL6 [Mapview hg38]
OMIM614214   
Gene and transcription
Genbank (Entrez)AF441792 AK024439 AK097125 AK097976 AK314473
RefSeq transcript (Entrez)NM_130446
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLHL6
Cluster EST : UnigeneHs.659147 [ NCBI ]
CGAP (NCI)Hs.659147
Alternative Splicing GalleryENSG00000172578
Gene ExpressionKLHL6 [ NCBI-GEO ]   KLHL6 [ EBI - ARRAY_EXPRESS ]   KLHL6 [ SEEK ]   KLHL6 [ MEM ]
Gene Expression Viewer (FireBrowse)KLHL6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89857
GTEX Portal (Tissue expression)KLHL6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WZ60   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WZ60  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WZ60
Splice isoforms : SwissVarQ8WZ60
PhosPhoSitePlusQ8WZ60
Domaine pattern : Prosite (Expaxy)BTB (PS50097)   
Domains : Interpro (EBI)BACK    BTB-kelch_protein    BTB/POZ_dom    Kelch-typ_b-propeller    Kelch_1    KLHL6    SKP1/BTB/POZ   
Domain families : Pfam (Sanger)BACK (PF07707)    BTB (PF00651)    Kelch_1 (PF01344)   
Domain families : Pfam (NCBI)pfam07707    pfam00651    pfam01344   
Domain families : Smart (EMBL)BACK (SM00875)  BTB (SM00225)  Kelch (SM00612)  
Conserved Domain (NCBI)KLHL6
DMDM Disease mutations89857
Blocks (Seattle)KLHL6
SuperfamilyQ8WZ60
Human Protein AtlasENSG00000172578
Peptide AtlasQ8WZ60
HPRD10035
IPIIPI00292468   IPI00929519   
Protein Interaction databases
DIP (DOE-UCLA)Q8WZ60
IntAct (EBI)Q8WZ60
FunCoupENSG00000172578
BioGRIDKLHL6
STRING (EMBL)KLHL6
ZODIACKLHL6
Ontologies - Pathways
QuickGOQ8WZ60
Ontology : AmiGOtranscription regulatory region sequence-specific DNA binding  germinal center formation  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  cytoplasm  regulation of transcription from RNA polymerase II promoter  positive regulation of transcription, DNA-templated  B cell receptor signaling pathway  
Ontology : EGO-EBItranscription regulatory region sequence-specific DNA binding  germinal center formation  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  cytoplasm  regulation of transcription from RNA polymerase II promoter  positive regulation of transcription, DNA-templated  B cell receptor signaling pathway  
NDEx NetworkKLHL6
Atlas of Cancer Signalling NetworkKLHL6
Wikipedia pathwaysKLHL6
Orthology - Evolution
OrthoDB89857
GeneTree (enSembl)ENSG00000172578
Phylogenetic Trees/Animal Genes : TreeFamKLHL6
HOVERGENQ8WZ60
HOGENOMQ8WZ60
Homologs : HomoloGeneKLHL6
Homology/Alignments : Family Browser (UCSC)KLHL6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLHL6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLHL6
dbVarKLHL6
ClinVarKLHL6
1000_GenomesKLHL6 
Exome Variant ServerKLHL6
ExAC (Exome Aggregation Consortium)KLHL6 (select the gene name)
Genetic variants : HAPMAP89857
Genomic Variants (DGV)KLHL6 [DGVbeta]
DECIPHERKLHL6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLHL6 
Mutations
ICGC Data PortalKLHL6 
TCGA Data PortalKLHL6 
Broad Tumor PortalKLHL6
OASIS PortalKLHL6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLHL6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLHL6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLHL6
DgiDB (Drug Gene Interaction Database)KLHL6
DoCM (Curated mutations)KLHL6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLHL6 (select a term)
intoGenKLHL6
Cancer3DKLHL6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614214   
Orphanet
MedgenKLHL6
Genetic Testing Registry KLHL6
NextProtQ8WZ60 [Medical]
TSGene89857
GENETestsKLHL6
Target ValidationKLHL6
Huge Navigator KLHL6 [HugePedia]
snp3D : Map Gene to Disease89857
BioCentury BCIQKLHL6
ClinGenKLHL6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD89857
Chemical/Pharm GKB GenePA38621
Clinical trialKLHL6
Miscellaneous
canSAR (ICR)KLHL6 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLHL6
EVEXKLHL6
GoPubMedKLHL6
iHOPKLHL6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:54:50 CEST 2017

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