Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KLHL7 (kelch like family member 7)

Identity

Alias_nameskelch-like 7 (Drosophila)
Alias_symbol (synonym)KLHL6
SBBI26
RP42
HGNC (Hugo) KLHL7
LocusID (NCBI) 55975
Atlas_Id 46434
Location 7p15.3  [Link to chromosome band 7p15]
Location_base_pair Starts at 23145353 and ends at 23215038 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FGF19 (11q13.3) / KLHL7 (7p15.3)KLHL7 (7p15.3) / BRD1 (22q13.33)KLHL7 (7p15.3) / CRKL (22q11.21)
KLHL7 (7p15.3) / DNAH11 (7p15.3)KLHL7 (7p15.3) / TPCN2 (11q13.3)MIR99AHG (21q21.1) / KLHL7 (7p15.3)
KLHL7 7p15.3 / DNAH11 7p15.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLHL7   15646
Cards
Entrez_Gene (NCBI)KLHL7  55975  kelch like family member 7
AliasesKLHL6; SBBI26
GeneCards (Weizmann)KLHL7
Ensembl hg19 (Hinxton)ENSG00000122550 [Gene_View]  chr7:23145353-23215038 [Contig_View]  KLHL7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000122550 [Gene_View]  chr7:23145353-23215038 [Contig_View]  KLHL7 [Vega]
ICGC DataPortalENSG00000122550
TCGA cBioPortalKLHL7
AceView (NCBI)KLHL7
Genatlas (Paris)KLHL7
WikiGenes55975
SOURCE (Princeton)KLHL7
Genetics Home Reference (NIH)KLHL7
Genomic and cartography
GoldenPath hg19 (UCSC)KLHL7  -     chr7:23145353-23215038 +  7p15.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KLHL7  -     7p15.3   [Description]    (hg38-Dec_2013)
EnsemblKLHL7 - 7p15.3 [CytoView hg19]  KLHL7 - 7p15.3 [CytoView hg38]
Mapping of homologs : NCBIKLHL7 [Mapview hg19]  KLHL7 [Mapview hg38]
OMIM611119   612943   
Gene and transcription
Genbank (Entrez)AA432360 AF111113 AK056390 AK290479 AK296219
RefSeq transcript (Entrez)NM_001031710 NM_001172428 NM_018846
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_016983 NT_007819 NW_004929329
Consensus coding sequences : CCDS (NCBI)KLHL7
Cluster EST : UnigeneHs.654817 [ NCBI ]
CGAP (NCI)Hs.654817
Alternative Splicing GalleryENSG00000122550
Gene ExpressionKLHL7 [ NCBI-GEO ]   KLHL7 [ EBI - ARRAY_EXPRESS ]   KLHL7 [ SEEK ]   KLHL7 [ MEM ]
Gene Expression Viewer (FireBrowse)KLHL7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55975
GTEX Portal (Tissue expression)KLHL7
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IXQ5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IXQ5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IXQ5
Splice isoforms : SwissVarQ8IXQ5
PhosPhoSitePlusQ8IXQ5
Domaine pattern : Prosite (Expaxy)BTB (PS50097)   
Domains : Interpro (EBI)BACK    BTB-kelch_protein    BTB/POZ_dom    Kelch-typ_b-propeller    Kelch_1    KLHL7    SKP1/BTB/POZ   
Domain families : Pfam (Sanger)BACK (PF07707)    BTB (PF00651)    Kelch_1 (PF01344)   
Domain families : Pfam (NCBI)pfam07707    pfam00651    pfam01344   
Domain families : Smart (EMBL)BACK (SM00875)  BTB (SM00225)  Kelch (SM00612)  
Conserved Domain (NCBI)KLHL7
DMDM Disease mutations55975
Blocks (Seattle)KLHL7
PDB (SRS)3II7   
PDB (PDBSum)3II7   
PDB (IMB)3II7   
PDB (RSDB)3II7   
Structural Biology KnowledgeBase3II7   
SCOP (Structural Classification of Proteins)3II7   
CATH (Classification of proteins structures)3II7   
SuperfamilyQ8IXQ5
Human Protein AtlasENSG00000122550
Peptide AtlasQ8IXQ5
HPRD13927
IPIIPI00186843   IPI00643493   IPI00001423   IPI00385471   IPI01012404   IPI01013619   IPI00941076   IPI01018899   IPI00982116   IPI00917818   IPI00916573   
Protein Interaction databases
DIP (DOE-UCLA)Q8IXQ5
IntAct (EBI)Q8IXQ5
FunCoupENSG00000122550
BioGRIDKLHL7
STRING (EMBL)KLHL7
ZODIACKLHL7
Ontologies - Pathways
QuickGOQ8IXQ5
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  plasma membrane  protein ubiquitination  Cul3-RING ubiquitin ligase complex  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  identical protein binding  protein homodimerization activity  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  plasma membrane  protein ubiquitination  Cul3-RING ubiquitin ligase complex  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  identical protein binding  protein homodimerization activity  
NDEx NetworkKLHL7
Atlas of Cancer Signalling NetworkKLHL7
Wikipedia pathwaysKLHL7
Orthology - Evolution
OrthoDB55975
GeneTree (enSembl)ENSG00000122550
Phylogenetic Trees/Animal Genes : TreeFamKLHL7
HOVERGENQ8IXQ5
HOGENOMQ8IXQ5
Homologs : HomoloGeneKLHL7
Homology/Alignments : Family Browser (UCSC)KLHL7
Gene fusions - Rearrangements
Fusion : MitelmanKLHL7/DNAH11 [7p15.3/7p15.3]  
Fusion: TCGAKLHL7 7p15.3 DNAH11 7p15.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLHL7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLHL7
dbVarKLHL7
ClinVarKLHL7
1000_GenomesKLHL7 
Exome Variant ServerKLHL7
ExAC (Exome Aggregation Consortium)KLHL7 (select the gene name)
Genetic variants : HAPMAP55975
Genomic Variants (DGV)KLHL7 [DGVbeta]
DECIPHER (Syndromes)7:23145353-23215038  ENSG00000122550
CONAN: Copy Number AnalysisKLHL7 
Mutations
ICGC Data PortalKLHL7 
TCGA Data PortalKLHL7 
Broad Tumor PortalKLHL7
OASIS PortalKLHL7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLHL7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLHL7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch KLHL7
DgiDB (Drug Gene Interaction Database)KLHL7
DoCM (Curated mutations)KLHL7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLHL7 (select a term)
intoGenKLHL7
Cancer3DKLHL7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611119    612943   
Orphanet659    17149   
MedgenKLHL7
Genetic Testing Registry KLHL7
NextProtQ8IXQ5 [Medical]
TSGene55975
GENETestsKLHL7
Huge Navigator KLHL7 [HugePedia]
snp3D : Map Gene to Disease55975
BioCentury BCIQKLHL7
ClinGenKLHL7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55975
Chemical/Pharm GKB GenePA38392
Clinical trialKLHL7
Miscellaneous
canSAR (ICR)KLHL7 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLHL7
EVEXKLHL7
GoPubMedKLHL7
iHOPKLHL7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:41:21 CET 2016

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