Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KLHL8 (kelch like family member 8)

Identity

Alias_nameskelch-like 8 (Drosophila)
Alias_symbol (synonym)KIAA1378
Other alias-
HGNC (Hugo) KLHL8
LocusID (NCBI) 57563
Atlas_Id 53760
Location 4q22.1  [Link to chromosome band 4q22]
Location_base_pair Starts at 88081256 and ends at 88141420 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KLHL8 (4q22.1) / HIST1H2AC (6p22.2)KLHL8 (4q22.1) / KLHL8 (4q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLHL8   18644
Cards
Entrez_Gene (NCBI)KLHL8  57563  kelch like family member 8
Aliases
GeneCards (Weizmann)KLHL8
Ensembl hg19 (Hinxton)ENSG00000145332 [Gene_View]  chr4:88081256-88141420 [Contig_View]  KLHL8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000145332 [Gene_View]  chr4:88081256-88141420 [Contig_View]  KLHL8 [Vega]
ICGC DataPortalENSG00000145332
TCGA cBioPortalKLHL8
AceView (NCBI)KLHL8
Genatlas (Paris)KLHL8
WikiGenes57563
SOURCE (Princeton)KLHL8
Genetics Home Reference (NIH)KLHL8
Genomic and cartography
GoldenPath hg19 (UCSC)KLHL8  -     chr4:88081256-88141420 -  4q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KLHL8  -     4q22.1   [Description]    (hg38-Dec_2013)
EnsemblKLHL8 - 4q22.1 [CytoView hg19]  KLHL8 - 4q22.1 [CytoView hg38]
Mapping of homologs : NCBIKLHL8 [Mapview hg19]  KLHL8 [Mapview hg38]
OMIM611967   
Gene and transcription
Genbank (Entrez)AA878129 AB037799 AK128827 AM393684 BC041370
RefSeq transcript (Entrez)NM_001292003 NM_001292006 NM_001292007 NM_020803
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)KLHL8
Cluster EST : UnigeneHs.106601 [ NCBI ]
CGAP (NCI)Hs.106601
Alternative Splicing GalleryENSG00000145332
Gene ExpressionKLHL8 [ NCBI-GEO ]   KLHL8 [ EBI - ARRAY_EXPRESS ]   KLHL8 [ SEEK ]   KLHL8 [ MEM ]
Gene Expression Viewer (FireBrowse)KLHL8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57563
GTEX Portal (Tissue expression)KLHL8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2G9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2G9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2G9
Splice isoforms : SwissVarQ9P2G9
PhosPhoSitePlusQ9P2G9
Domaine pattern : Prosite (Expaxy)BTB (PS50097)   
Domains : Interpro (EBI)BACK    BTB/POZ_dom    Gal_Oxase/kelch_b-propeller    Gal_Oxidase_b-propeller    Kelch_1    KLHL8    SKP1/BTB/POZ   
Domain families : Pfam (Sanger)BACK (PF07707)    BTB (PF00651)    Kelch_1 (PF01344)   
Domain families : Pfam (NCBI)pfam07707    pfam00651    pfam01344   
Domain families : Smart (EMBL)BACK (SM00875)  BTB (SM00225)  Kelch (SM00612)  
Conserved Domain (NCBI)KLHL8
DMDM Disease mutations57563
Blocks (Seattle)KLHL8
SuperfamilyQ9P2G9
Human Protein AtlasENSG00000145332
Peptide AtlasQ9P2G9
HPRD13928
IPIIPI00292917   IPI00953380   IPI00784474   IPI01014970   IPI00966402   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2G9
IntAct (EBI)Q9P2G9
FunCoupENSG00000145332
BioGRIDKLHL8
STRING (EMBL)KLHL8
ZODIACKLHL8
Ontologies - Pathways
QuickGOQ9P2G9
Ontology : AmiGOubiquitin-protein transferase activity  nucleoplasm  protein ubiquitination  Cul3-RING ubiquitin ligase complex  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
Ontology : EGO-EBIubiquitin-protein transferase activity  nucleoplasm  protein ubiquitination  Cul3-RING ubiquitin ligase complex  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
NDEx NetworkKLHL8
Atlas of Cancer Signalling NetworkKLHL8
Wikipedia pathwaysKLHL8
Orthology - Evolution
OrthoDB57563
GeneTree (enSembl)ENSG00000145332
Phylogenetic Trees/Animal Genes : TreeFamKLHL8
HOVERGENQ9P2G9
HOGENOMQ9P2G9
Homologs : HomoloGeneKLHL8
Homology/Alignments : Family Browser (UCSC)KLHL8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLHL8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLHL8
dbVarKLHL8
ClinVarKLHL8
1000_GenomesKLHL8 
Exome Variant ServerKLHL8
ExAC (Exome Aggregation Consortium)KLHL8 (select the gene name)
Genetic variants : HAPMAP57563
Genomic Variants (DGV)KLHL8 [DGVbeta]
DECIPHER (Syndromes)4:88081256-88141420  ENSG00000145332
CONAN: Copy Number AnalysisKLHL8 
Mutations
ICGC Data PortalKLHL8 
TCGA Data PortalKLHL8 
Broad Tumor PortalKLHL8
OASIS PortalKLHL8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLHL8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLHL8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLHL8
DgiDB (Drug Gene Interaction Database)KLHL8
DoCM (Curated mutations)KLHL8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLHL8 (select a term)
intoGenKLHL8
Cancer3DKLHL8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611967   
Orphanet
MedgenKLHL8
Genetic Testing Registry KLHL8
NextProtQ9P2G9 [Medical]
TSGene57563
GENETestsKLHL8
Huge Navigator KLHL8 [HugePedia]
snp3D : Map Gene to Disease57563
BioCentury BCIQKLHL8
ClinGenKLHL8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57563
Chemical/Pharm GKB GenePA38616
Clinical trialKLHL8
Miscellaneous
canSAR (ICR)KLHL8 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLHL8
EVEXKLHL8
GoPubMedKLHL8
iHOPKLHL8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:06:22 CEST 2017

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