Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

KLK1 (kallikrein 1)

Identity

Alias_nameskallikrein 1
Alias_symbol (synonym)Klk6
Other aliasKLKR
hK1
HGNC (Hugo) KLK1
LocusID (NCBI) 3816
Atlas_Id 41075
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 51322402 and ends at 51327043 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KLK1 (19q13.33) / EFHD2 (1p36.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLK1   6357
Cards
Entrez_Gene (NCBI)KLK1  3816  kallikrein 1
AliasesKLKR; Klk6; hK1
GeneCards (Weizmann)KLK1
Ensembl hg19 (Hinxton)ENSG00000167748 [Gene_View]  chr19:51322402-51327043 [Contig_View]  KLK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000167748 [Gene_View]  chr19:51322402-51327043 [Contig_View]  KLK1 [Vega]
ICGC DataPortalENSG00000167748
TCGA cBioPortalKLK1
AceView (NCBI)KLK1
Genatlas (Paris)KLK1
WikiGenes3816
SOURCE (Princeton)KLK1
Genetics Home Reference (NIH)KLK1
Genomic and cartography
GoldenPath hg19 (UCSC)KLK1  -     chr19:51322402-51327043 -  19q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KLK1  -     19q13.33   [Description]    (hg38-Dec_2013)
EnsemblKLK1 - 19q13.33 [CytoView hg19]  KLK1 - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBIKLK1 [Mapview hg19]  KLK1 [Mapview hg38]
OMIM147910   615953   
Gene and transcription
Genbank (Entrez)AK293363 AY429508 AY703451 BC005313 BP323011
RefSeq transcript (Entrez)NM_002257
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_012094 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)KLK1
Cluster EST : UnigeneHs.123107 [ NCBI ]
CGAP (NCI)Hs.123107
Alternative Splicing GalleryENSG00000167748
Gene ExpressionKLK1 [ NCBI-GEO ]   KLK1 [ EBI - ARRAY_EXPRESS ]   KLK1 [ SEEK ]   KLK1 [ MEM ]
Gene Expression Viewer (FireBrowse)KLK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3816
GTEX Portal (Tissue expression)KLK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06870   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06870  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06870
Splice isoforms : SwissVarP06870
Catalytic activity : Enzyme3.4.21.35 [ Enzyme-Expasy ]   3.4.21.353.4.21.35 [ IntEnz-EBI ]   3.4.21.35 [ BRENDA ]   3.4.21.35 [ KEGG ]   
PhosPhoSitePlusP06870
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)KLK1
DMDM Disease mutations3816
Blocks (Seattle)KLK1
PDB (SRS)1SPJ   
PDB (PDBSum)1SPJ   
PDB (IMB)1SPJ   
PDB (RSDB)1SPJ   
Structural Biology KnowledgeBase1SPJ   
SCOP (Structural Classification of Proteins)1SPJ   
CATH (Classification of proteins structures)1SPJ   
SuperfamilyP06870
Human Protein AtlasENSG00000167748
Peptide AtlasP06870
HPRD01003
IPIIPI00304808   IPI00930404   IPI01026288   
Protein Interaction databases
DIP (DOE-UCLA)P06870
IntAct (EBI)P06870
FunCoupENSG00000167748
BioGRIDKLK1
STRING (EMBL)KLK1
ZODIACKLK1
Ontologies - Pathways
QuickGOP06870
Ontology : AmiGOserine-type endopeptidase activity  nucleus  proteolysis  extracellular exosome  
Ontology : EGO-EBIserine-type endopeptidase activity  nucleus  proteolysis  extracellular exosome  
Pathways : KEGGEndocrine and other factor-regulated calcium reabsorption   
NDEx NetworkKLK1
Atlas of Cancer Signalling NetworkKLK1
Wikipedia pathwaysKLK1
Orthology - Evolution
OrthoDB3816
GeneTree (enSembl)ENSG00000167748
Phylogenetic Trees/Animal Genes : TreeFamKLK1
HOVERGENP06870
HOGENOMP06870
Homologs : HomoloGeneKLK1
Homology/Alignments : Family Browser (UCSC)KLK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLK1
dbVarKLK1
ClinVarKLK1
1000_GenomesKLK1 
Exome Variant ServerKLK1
ExAC (Exome Aggregation Consortium)KLK1 (select the gene name)
Genetic variants : HAPMAP3816
Genomic Variants (DGV)KLK1 [DGVbeta]
DECIPHER (Syndromes)19:51322402-51327043  ENSG00000167748
CONAN: Copy Number AnalysisKLK1 
Mutations
ICGC Data PortalKLK1 
TCGA Data PortalKLK1 
Broad Tumor PortalKLK1
OASIS PortalKLK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLK1
DgiDB (Drug Gene Interaction Database)KLK1
DoCM (Curated mutations)KLK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLK1 (select a term)
intoGenKLK1
Cancer3DKLK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147910    615953   
Orphanet
MedgenKLK1
Genetic Testing Registry KLK1
NextProtP06870 [Medical]
TSGene3816
GENETestsKLK1
Huge Navigator KLK1 [HugePedia]
snp3D : Map Gene to Disease3816
BioCentury BCIQKLK1
ClinGenKLK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3816
Chemical/Pharm GKB GenePA224
Clinical trialKLK1
Miscellaneous
canSAR (ICR)KLK1 (select the gene name)
Probes
Litterature
PubMed110 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLK1
EVEXKLK1
GoPubMedKLK1
iHOPKLK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:06:23 CEST 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.