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KLK12 (kallikrein related peptidase 12)

Identity

Other namesKLK-L5
KLKL5
HGNC (Hugo) KLK12
LocusID (NCBI) 43849
Atlas_Id 41078
Location 19q13.41
Location_base_pair Starts at 51532348 and ends at 51538148 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLK12   6360
Cards
Entrez_Gene (NCBI)KLK12  43849  kallikrein related peptidase 12
GeneCards (Weizmann)KLK12
Ensembl hg19 (Hinxton)ENSG00000186474 [Gene_View]  chr19:51532348-51538148 [Contig_View]  KLK12 [Vega]
Ensembl hg38 (Hinxton)ENSG00000186474 [Gene_View]  chr19:51532348-51538148 [Contig_View]  KLK12 [Vega]
ICGC DataPortalENSG00000186474
TCGA cBioPortalKLK12
AceView (NCBI)KLK12
Genatlas (Paris)KLK12
WikiGenes43849
SOURCE (Princeton)KLK12
Genomic and cartography
GoldenPath hg19 (UCSC)KLK12  -     chr19:51532348-51538148 -  19q13.41   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KLK12  -     19q13.41   [Description]    (hg38-Dec_2013)
EnsemblKLK12 - 19q13.41 [CytoView hg19]  KLK12 - 19q13.41 [CytoView hg38]
Mapping of homologs : NCBIKLK12 [Mapview hg19]  KLK12 [Mapview hg38]
OMIM605539   
Gene and transcription
Genbank (Entrez)AY358524 BC035385 BC136341 BC143988 BC143990
RefSeq transcript (Entrez)NM_019598 NM_145894 NM_145895
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)KLK12
Cluster EST : UnigeneHs.411572 [ NCBI ]
CGAP (NCI)Hs.411572
Alternative Splicing GalleryENSG00000186474
Gene ExpressionKLK12 [ NCBI-GEO ]   KLK12 [ EBI - ARRAY_EXPRESS ]   KLK12 [ SEEK ]   KLK12 [ MEM ]
Gene Expression Viewer (FireBrowse)KLK12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)43849
GTEX Portal (Tissue expression)KLK12
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKR0 (Uniprot)
NextProtQ9UKR0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKR0
Splice isoforms : SwissVarQ9UKR0 (Swissvar)
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusQ9UKR0
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
DMDM Disease mutations43849
Blocks (Seattle)KLK12
SuperfamilyQ9UKR0
Human Protein AtlasENSG00000186474
Peptide AtlasQ9UKR0
HPRD05705
IPIIPI00007724   IPI00220155   IPI00941336   IPI00395677   IPI00983268   IPI00985039   IPI00010516   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKR0
IntAct (EBI)Q9UKR0
FunCoupENSG00000186474
BioGRIDKLK12
STRING (EMBL)KLK12
ZODIACKLK12
Ontologies - Pathways
QuickGOQ9UKR0
Ontology : AmiGOserine-type endopeptidase activity  serine-type endopeptidase activity  extracellular space  proteolysis  peptidase activity  serine-type peptidase activity  extracellular exosome  
Ontology : EGO-EBIserine-type endopeptidase activity  serine-type endopeptidase activity  extracellular space  proteolysis  peptidase activity  serine-type peptidase activity  extracellular exosome  
NDEx Network
Atlas of Cancer Signalling NetworkKLK12
Wikipedia pathwaysKLK12
Orthology - Evolution
OrthoDB43849
GeneTree (enSembl)ENSG00000186474
Phylogenetic Trees/Animal Genes : TreeFamKLK12
Homologs : HomoloGeneKLK12
Homology/Alignments : Family Browser (UCSC)KLK12
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerKLK12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLK12
dbVarKLK12
ClinVarKLK12
1000_GenomesKLK12 
Exome Variant ServerKLK12
ExAC (Exome Aggregation Consortium)KLK12 (select the gene name)
Genetic variants : HAPMAP43849
Genomic Variants (DGV)KLK12 [DGVbeta]
Mutations
ICGC Data PortalKLK12 
TCGA Data PortalKLK12 
Broad Tumor PortalKLK12
OASIS PortalKLK12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLK12 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLK12
DgiDB (Drug Gene Interaction Database)KLK12
DoCM (Curated mutations)KLK12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLK12 (select a term)
intoGenKLK12
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:51532348-51538148  ENSG00000186474
CONAN: Copy Number AnalysisKLK12 
Mutations and Diseases : HGMDKLK12
OMIM605539   
MedgenKLK12
Genetic Testing Registry KLK12
NextProtQ9UKR0 [Medical]
TSGene43849
GENETestsKLK12
Huge Navigator KLK12 [HugePedia]
snp3D : Map Gene to Disease43849
BioCentury BCIQKLK12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD43849
Chemical/Pharm GKB GenePA30149
Clinical trialKLK12
Miscellaneous
canSAR (ICR)KLK12 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLK12
EVEXKLK12
GoPubMedKLK12
iHOPKLK12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 18:52:04 CEST 2016

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