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KLK14 (kallikrein-related peptidase 14)

Identity

Other namesKLK-L6
HGNC (Hugo) KLK14
LocusID (NCBI) 43847
Location 19q13.41
Location_base_pair Starts at 51581154 and ends at 51587502 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)KLK14   6362
Cards
Entrez_Gene (NCBI)KLK14  43847  kallikrein-related peptidase 14
GeneCards (Weizmann)KLK14
Ensembl hg19 (Hinxton)ENSG00000129437 [Gene_View]  chr19:51581154-51587502 [Contig_View]  KLK14 [Vega]
Ensembl hg38 (Hinxton)ENSG00000129437 [Gene_View]  chr19:51581154-51587502 [Contig_View]  KLK14 [Vega]
ICGC DataPortalENSG00000129437
cBioPortalKLK14
AceView (NCBI)KLK14
Genatlas (Paris)KLK14
WikiGenes43847
SOURCE (Princeton)KLK14
Genomic and cartography
GoldenPath hg19 (UCSC)KLK14  -     chr19:51581154-51587502 -  19q13.41   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KLK14  -     19q13.41   [Description]    (hg38-Dec_2013)
EnsemblKLK14 - 19q13.41 [CytoView hg19]  KLK14 - 19q13.41 [CytoView hg38]
Mapping of homologs : NCBIKLK14 [Mapview hg19]  KLK14 [Mapview hg38]
OMIM606135   
Gene and transcription
Genbank (Entrez)AF283670 BC074904 BC074905 BC114614
RefSeq transcript (Entrez)NM_022046
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NT_011109 NW_001838498 NW_004929415
Consensus coding sequences : CCDS (NCBI)KLK14
Cluster EST : UnigeneHs.283925 [ NCBI ]
CGAP (NCI)Hs.283925
Alternative Splicing : Fast-db (Paris)GSHG0016045
Alternative Splicing GalleryENSG00000129437
Gene ExpressionKLK14 [ NCBI-GEO ]     KLK14 [ SEEK ]   KLK14 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P0G3 (Uniprot)
NextProtQ9P0G3  [Medical]
With graphics : InterProQ9P0G3
Splice isoforms : SwissVarQ9P0G3 (Swissvar)
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1    Peptidase_S1_AS    Peptidase_S1A    Trypsin-like_Pept_dom   
Related proteins : CluSTrQ9P0G3
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
DMDM Disease mutations43847
Blocks (Seattle)Q9P0G3
Human Protein AtlasENSG00000129437
Peptide AtlasQ9P0G3
HPRD05844
IPIIPI00000700   
Protein Interaction databases
DIP (DOE-UCLA)Q9P0G3
IntAct (EBI)Q9P0G3
FunCoupENSG00000129437
BioGRIDKLK14
IntegromeDBKLK14
STRING (EMBL)KLK14
Ontologies - Pathways
QuickGOQ9P0G3
Ontology : AmiGOserine-type endopeptidase activity  serine-type endopeptidase activity  extracellular space  proteolysis  fertilization  negative regulation of G-protein coupled receptor protein signaling pathway  positive regulation of G-protein coupled receptor protein signaling pathway  epidermis morphogenesis  extracellular vesicular exosome  seminal clot liquefaction  
Ontology : EGO-EBIserine-type endopeptidase activity  serine-type endopeptidase activity  extracellular space  proteolysis  fertilization  negative regulation of G-protein coupled receptor protein signaling pathway  positive regulation of G-protein coupled receptor protein signaling pathway  epidermis morphogenesis  extracellular vesicular exosome  seminal clot liquefaction  
Protein Interaction DatabaseKLK14
DoCM (Curated mutations)KLK14
Wikipedia pathwaysKLK14
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerKLK14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLK14
dbVarKLK14
ClinVarKLK14
1000_GenomesKLK14 
Exome Variant ServerKLK14
SNP (GeneSNP Utah)KLK14
SNP : HGBaseKLK14
Genetic variants : HAPMAPKLK14
Genomic VariantsKLK14  KLK14 [DGVbeta]
Mutations
ICGC Data PortalENSG00000129437 
Somatic Mutations in Cancer : COSMICKLK14 
CONAN: Copy Number AnalysisKLK14 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:51581154-51587502
Mutations and Diseases : HGMDKLK14
OMIM606135   
MedgenKLK14
NextProtQ9P0G3 [Medical]
GENETestsKLK14
Disease Genetic AssociationKLK14
Huge Navigator KLK14 [HugePedia]  KLK14 [HugeCancerGEM]
snp3D : Map Gene to Disease43847
DGIdb (Drug Gene Interaction db)KLK14
General knowledge
Homologs : HomoloGeneKLK14
Homology/Alignments : Family Browser (UCSC)KLK14
Phylogenetic Trees/Animal Genes : TreeFamKLK14
Chemical/Protein Interactions : CTD43847
Chemical/Pharm GKB GenePA30151
Clinical trialKLK14
Cancer Resource (Charite)ENSG00000129437
Other databases
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
CoreMineKLK14
GoPubMedKLK14
iHOPKLK14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:20:32 CET 2014

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