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KLK2 (kallikrein related peptidase 2)

Identity

Alias_nameskallikrein 2
Other aliasKLK2A2
hGK-1
hK2
HGNC (Hugo) KLK2
LocusID (NCBI) 3817
Atlas_Id 41082
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 50873433 and ends at 50880567 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ETV4 (17q21.31) / KLK2 (19q13.33)KLK2 (19q13.33) / ETV1 (7p21.2)KLK2 (19q13.33) / ETV4 (17q21.31)
KLK2 (19q13.33) / KLK2 (19q13.33)KLK2 (19q13.33) / RDH11 (14q24.1)TOMM7 (7p15.3) / KLK2 (19q13.33)
KLK2 19q13.33 / ETV1 7p21.2KLK2 19q13.33 / ETV4 17q21.31TOMM7 7p15.3 / KLK2 19q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Prostate tumors: an overview
t(7;19)(p15;q13) TOMM7/KLK2
t(7;19)(p21;q13) KLK2/ETV1

External links

Nomenclature
HGNC (Hugo)KLK2   6363
Cards
Entrez_Gene (NCBI)KLK2  3817  kallikrein related peptidase 2
AliasesKLK2A2; hGK-1; hK2
GeneCards (Weizmann)KLK2
Ensembl hg19 (Hinxton)ENSG00000167751 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167751 [Gene_View]  ENSG00000167751 [Sequence]  chr19:50873433-50880567 [Contig_View]  KLK2 [Vega]
ICGC DataPortalENSG00000167751
TCGA cBioPortalKLK2
AceView (NCBI)KLK2
Genatlas (Paris)KLK2
WikiGenes3817
SOURCE (Princeton)KLK2
Genetics Home Reference (NIH)KLK2
Genomic and cartography
GoldenPath hg38 (UCSC)KLK2  -     chr19:50873433-50880567 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLK2  -     19q13.33   [Description]    (hg19-Feb_2009)
GoldenPathKLK2 - 19q13.33 [CytoView hg19]  KLK2 - 19q13.33 [CytoView hg38]
ImmunoBaseENSG00000167751
Mapping of homologs : NCBIKLK2 [Mapview hg19]  KLK2 [Mapview hg38]
OMIM147960   
Gene and transcription
Genbank (Entrez)AF188745 AF188746 AF188747 AF336106 AK300527
RefSeq transcript (Entrez)NM_001002231 NM_001002232 NM_001256080 NM_005551
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLK2
Cluster EST : UnigeneHs.515560 [ NCBI ]
CGAP (NCI)Hs.515560
Alternative Splicing GalleryENSG00000167751
Gene ExpressionKLK2 [ NCBI-GEO ]   KLK2 [ EBI - ARRAY_EXPRESS ]   KLK2 [ SEEK ]   KLK2 [ MEM ]
Gene Expression Viewer (FireBrowse)KLK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3817
GTEX Portal (Tissue expression)KLK2
Human Protein AtlasENSG00000167751-KLK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20151   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20151  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20151
Splice isoforms : SwissVarP20151
Catalytic activity : Enzyme3.4.21.35 [ Enzyme-Expasy ]   3.4.21.353.4.21.35 [ IntEnz-EBI ]   3.4.21.35 [ BRENDA ]   3.4.21.35 [ KEGG ]   
PhosPhoSitePlusP20151
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)KLK2
DMDM Disease mutations3817
Blocks (Seattle)KLK2
PDB (RSDB)4NFE    4NFF   
PDB Europe4NFE    4NFF   
PDB (PDBSum)4NFE    4NFF   
PDB (IMB)4NFE    4NFF   
Structural Biology KnowledgeBase4NFE    4NFF   
SCOP (Structural Classification of Proteins)4NFE    4NFF   
CATH (Classification of proteins structures)4NFE    4NFF   
SuperfamilyP20151
Human Protein Atlas [tissue]ENSG00000167751-KLK2 [tissue]
Peptide AtlasP20151
HPRD01006
IPIIPI00022227   IPI00434943   IPI00219231   IPI00447786   IPI01018195   IPI00383167   IPI00976143   
Protein Interaction databases
DIP (DOE-UCLA)P20151
IntAct (EBI)P20151
FunCoupENSG00000167751
BioGRIDKLK2
STRING (EMBL)KLK2
ZODIACKLK2
Ontologies - Pathways
QuickGOP20151
Ontology : AmiGOregulation of systemic arterial blood pressure  serine-type endopeptidase activity  serine-type endopeptidase activity  extracellular region  extracellular matrix disassembly  secretory granule  zymogen activation  extracellular exosome  
Ontology : EGO-EBIregulation of systemic arterial blood pressure  serine-type endopeptidase activity  serine-type endopeptidase activity  extracellular region  extracellular matrix disassembly  secretory granule  zymogen activation  extracellular exosome  
Pathways : KEGGEndocrine and other factor-regulated calcium reabsorption   
NDEx NetworkKLK2
Atlas of Cancer Signalling NetworkKLK2
Wikipedia pathwaysKLK2
Orthology - Evolution
OrthoDB3817
GeneTree (enSembl)ENSG00000167751
Phylogenetic Trees/Animal Genes : TreeFamKLK2
HOGENOMP20151
Homologs : HomoloGeneKLK2
Homology/Alignments : Family Browser (UCSC)KLK2
Gene fusions - Rearrangements
Fusion : MitelmanKLK2/ETV1 [19q13.33/7p21.2]  
Fusion : MitelmanKLK2/ETV4 [19q13.33/17q21.31]  [t(17;19)(q21;q13)]  
Fusion : MitelmanTOMM7/KLK2 [7p15.3/19q13.33]  [t(7;19)(p15;q13)]  
Fusion PortalTOMM7 7p15.3 KLK2 19q13.33 PRAD
Fusion : QuiverKLK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLK2
dbVarKLK2
ClinVarKLK2
1000_GenomesKLK2 
Exome Variant ServerKLK2
ExAC (Exome Aggregation Consortium)ENSG00000167751
GNOMAD BrowserENSG00000167751
Varsome BrowserKLK2
Genetic variants : HAPMAP3817
Genomic Variants (DGV)KLK2 [DGVbeta]
DECIPHERKLK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLK2 
Mutations
ICGC Data PortalKLK2 
TCGA Data PortalKLK2 
Broad Tumor PortalKLK2
OASIS PortalKLK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLK2
DgiDB (Drug Gene Interaction Database)KLK2
DoCM (Curated mutations)KLK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLK2 (select a term)
intoGenKLK2
Cancer3DKLK2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147960   
Orphanet
DisGeNETKLK2
MedgenKLK2
Genetic Testing Registry KLK2
NextProtP20151 [Medical]
TSGene3817
GENETestsKLK2
Target ValidationKLK2
Huge Navigator KLK2 [HugePedia]
snp3D : Map Gene to Disease3817
BioCentury BCIQKLK2
ClinGenKLK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3817
Chemical/Pharm GKB GenePA30152
Clinical trialKLK2
Miscellaneous
canSAR (ICR)KLK2 (select the gene name)
DataMed IndexKLK2
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLK2
EVEXKLK2
GoPubMedKLK2
iHOPKLK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 7 18:06:09 CEST 2019
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