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KLK3 (kallikrein related peptidase 3)

Identity

Alias (NCBI)APS
KLK2A1
PSA
hK3
HGNC (Hugo) KLK3
HGNC Alias symbPSA
HGNC Previous nameAPS
HGNC Previous namekallikrein 3, (prostate specific antigen)
LocusID (NCBI) 354
Atlas_Id 41083
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 50854915 and ends at 50860764 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FBRS (16p11.2) / KLK3 (19q13.33)KLK3 (19q13.33) / CACNB2 (10p12.33)KLK3 (19q13.33) / CDC42EP4 (17q25.1)
KLK3 (19q13.33) / GSN (9q33.2)KLK3 (19q13.33) / KLK3 (19q13.33)KLK3 (19q13.33) / LOC646329 ()
KLK3 (19q13.33) / MALAT1 (11q13.1)KLK3 (19q13.33) / PSMD7 (16q23.1)RORA (15q22.2) / KLK3 (19q13.33)
VPS4A (16q22.1) / KLK3 (19q13.33)ZC3H3 (8q24.3) / KLK3 (19q13.33)ZC3H3 8q24.3 / KLK3 19q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KLK3   6364
Cards
Entrez_Gene (NCBI)KLK3    kallikrein related peptidase 3
AliasesAPS; KLK2A1; PSA; hK3
GeneCards (Weizmann)KLK3
Ensembl hg19 (Hinxton)ENSG00000142515 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142515 [Gene_View]  ENSG00000142515 [Sequence]  chr19:50854915-50860764 [Contig_View]  KLK3 [Vega]
ICGC DataPortalENSG00000142515
TCGA cBioPortalKLK3
AceView (NCBI)KLK3
Genatlas (Paris)KLK3
SOURCE (Princeton)KLK3
Genetics Home Reference (NIH)KLK3
Genomic and cartography
GoldenPath hg38 (UCSC)KLK3  -     chr19:50854915-50860764 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLK3  -     19q13.33   [Description]    (hg19-Feb_2009)
GoldenPathKLK3 - 19q13.33 [CytoView hg19]  KLK3 - 19q13.33 [CytoView hg38]
ImmunoBaseENSG00000142515
Genome Data Viewer NCBIKLK3 [Mapview hg19]  
OMIM176820   
Gene and transcription
Genbank (Entrez)AF335477 AF335478 AJ310937 AJ310938 AJ459782
RefSeq transcript (Entrez)NM_001030047 NM_001030048 NM_001030049 NM_001030050 NM_001648
Consensus coding sequences : CCDS (NCBI)KLK3
Gene ExpressionKLK3 [ NCBI-GEO ]   KLK3 [ EBI - ARRAY_EXPRESS ]   KLK3 [ SEEK ]   KLK3 [ MEM ]
Gene Expression Viewer (FireBrowse)KLK3 [ Firebrowse - Broad ]
GenevisibleExpression of KLK3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)354
GTEX Portal (Tissue expression)KLK3
Human Protein AtlasENSG00000142515-KLK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07288   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07288  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07288
Catalytic activity : Enzyme3.4.21.77 [ Enzyme-Expasy ]   3.4.21.773.4.21.77 [ IntEnz-EBI ]   3.4.21.77 [ BRENDA ]   3.4.21.77 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP07288
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1_PA_chymotrypsin    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)KLK3
PDB (RSDB)1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
PDB Europe1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
PDB (PDBSum)1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
PDB (IMB)1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
Structural Biology KnowledgeBase1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
SCOP (Structural Classification of Proteins)1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
CATH (Classification of proteins structures)1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
SuperfamilyP07288
AlphaFold pdb e-kbP07288   
Human Protein Atlas [tissue]ENSG00000142515-KLK3 [tissue]
HPRD01461
Protein Interaction databases
DIP (DOE-UCLA)P07288
IntAct (EBI)P07288
BioGRIDKLK3
STRING (EMBL)KLK3
ZODIACKLK3
Ontologies - Pathways
QuickGOP07288
Ontology : AmiGOpositive regulation of antibacterial peptide production  regulation of systemic arterial blood pressure  endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular region  extracellular space  nucleus  proteolysis  serine-type peptidase activity  negative regulation of angiogenesis  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides  secretory granule  zymogen activation  protein-containing complex  cellular protein metabolic process  regulation of androgen receptor signaling pathway  extracellular exosome  
Ontology : EGO-EBIpositive regulation of antibacterial peptide production  regulation of systemic arterial blood pressure  endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular region  extracellular space  nucleus  proteolysis  serine-type peptidase activity  negative regulation of angiogenesis  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides  secretory granule  zymogen activation  protein-containing complex  cellular protein metabolic process  regulation of androgen receptor signaling pathway  extracellular exosome  
Pathways : KEGGPathways in cancer    Prostate cancer   
NDEx NetworkKLK3
Atlas of Cancer Signalling NetworkKLK3
Wikipedia pathwaysKLK3
Orthology - Evolution
OrthoDB354
GeneTree (enSembl)ENSG00000142515
Phylogenetic Trees/Animal Genes : TreeFamKLK3
Homologs : HomoloGeneKLK3
Homology/Alignments : Family Browser (UCSC)KLK3
Gene fusions - Rearrangements
Fusion : MitelmanZC3H3/KLK3 [8q24.3/19q13.33]  
Fusion : QuiverKLK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLK3
dbVarKLK3
ClinVarKLK3
MonarchKLK3
1000_GenomesKLK3 
Exome Variant ServerKLK3
GNOMAD BrowserENSG00000142515
Varsome BrowserKLK3
ACMGKLK3 variants
VarityP07288
Genomic Variants (DGV)KLK3 [DGVbeta]
DECIPHERKLK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLK3 
Mutations
ICGC Data PortalKLK3 
TCGA Data PortalKLK3 
Broad Tumor PortalKLK3
OASIS PortalKLK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLK3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKLK3
Mutations and Diseases : HGMDKLK3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKLK3
DgiDB (Drug Gene Interaction Database)KLK3
DoCM (Curated mutations)KLK3
CIViC (Clinical Interpretations of Variants in Cancer)KLK3
Cancer3DKLK3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176820   
Orphanet
DisGeNETKLK3
MedgenKLK3
Genetic Testing Registry KLK3
NextProtP07288 [Medical]
GENETestsKLK3
Target ValidationKLK3
Huge Navigator KLK3 [HugePedia]
ClinGenKLK3
Clinical trials, drugs, therapy
MyCancerGenomeKLK3
Protein Interactions : CTDKLK3
Pharm GKB GenePA164741810
PharosP07288
Clinical trialKLK3
Miscellaneous
canSAR (ICR)KLK3
HarmonizomeKLK3
DataMed IndexKLK3
Probes
Litterature
PubMed447 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKLK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:15:14 CEST 2021

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