Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KLK6 (kallikrein related peptidase 6)

Identity

Alias_namesPRSS9
PRSS18
protease, serine, 18
kallikrein 6 (neurosin, zyme)
Alias_symbol (synonym)Bssp
Klk7
neurosin
Other aliasSP59
hK6
HGNC (Hugo) KLK6
LocusID (NCBI) 5653
Atlas_Id 41086
Location 19q13.41  [Link to chromosome band 19q13]
Location_base_pair Starts at 50958631 and ends at 50968972 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGAP23 (17q12) / KLK6 (19q13.41)KLK6 (19q13.41) / BAD (11q13.1)KLK6 (19q13.41) / KLK6 (19q13.41)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLK6   6367
Cards
Entrez_Gene (NCBI)KLK6  5653  kallikrein related peptidase 6
AliasesBssp; Klk7; PRSS18; PRSS9; 
SP59; hK6
GeneCards (Weizmann)KLK6
Ensembl hg19 (Hinxton)ENSG00000167755 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167755 [Gene_View]  chr19:50958631-50968972 [Contig_View]  KLK6 [Vega]
ICGC DataPortalENSG00000167755
TCGA cBioPortalKLK6
AceView (NCBI)KLK6
Genatlas (Paris)KLK6
WikiGenes5653
SOURCE (Princeton)KLK6
Genetics Home Reference (NIH)KLK6
Genomic and cartography
GoldenPath hg38 (UCSC)KLK6  -     chr19:50958631-50968972 -  19q13.41   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLK6  -     19q13.41   [Description]    (hg19-Feb_2009)
EnsemblKLK6 - 19q13.41 [CytoView hg19]  KLK6 - 19q13.41 [CytoView hg38]
Mapping of homologs : NCBIKLK6 [Mapview hg19]  KLK6 [Mapview hg38]
OMIM602652   
Gene and transcription
Genbank (Entrez)AF013988 AK314897 AY279383 AY318867 AY318868
RefSeq transcript (Entrez)NM_001012964 NM_001012965 NM_001319948 NM_001319949 NM_002774
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLK6
Cluster EST : UnigeneHs.79361 [ NCBI ]
CGAP (NCI)Hs.79361
Alternative Splicing GalleryENSG00000167755
Gene ExpressionKLK6 [ NCBI-GEO ]   KLK6 [ EBI - ARRAY_EXPRESS ]   KLK6 [ SEEK ]   KLK6 [ MEM ]
Gene Expression Viewer (FireBrowse)KLK6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5653
GTEX Portal (Tissue expression)KLK6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92876   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92876  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92876
Splice isoforms : SwissVarQ92876
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusQ92876
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)KLK6
DMDM Disease mutations5653
Blocks (Seattle)KLK6
PDB (SRS)1GVL    1L2E    1LO6    3VFE    4D8N   
PDB (PDBSum)1GVL    1L2E    1LO6    3VFE    4D8N   
PDB (IMB)1GVL    1L2E    1LO6    3VFE    4D8N   
PDB (RSDB)1GVL    1L2E    1LO6    3VFE    4D8N   
Structural Biology KnowledgeBase1GVL    1L2E    1LO6    3VFE    4D8N   
SCOP (Structural Classification of Proteins)1GVL    1L2E    1LO6    3VFE    4D8N   
CATH (Classification of proteins structures)1GVL    1L2E    1LO6    3VFE    4D8N   
SuperfamilyQ92876
Human Protein AtlasENSG00000167755
Peptide AtlasQ92876
HPRD04037
IPIIPI00023845   IPI00554738   IPI00896372   IPI00426071   
Protein Interaction databases
DIP (DOE-UCLA)Q92876
IntAct (EBI)Q92876
FunCoupENSG00000167755
BioGRIDKLK6
STRING (EMBL)KLK6
ZODIACKLK6
Ontologies - Pathways
QuickGOQ92876
Ontology : AmiGOserine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  nucleolus  cytoplasm  mitochondrion  endoplasmic reticulum  central nervous system development  response to wounding  regulation of neuron projection development  protein processing  protein autoprocessing  collagen catabolic process  tissue regeneration  hormone metabolic process  myelination  amyloid precursor protein metabolic process  regulation of cell differentiation  positive regulation of G-protein coupled receptor protein signaling pathway  neuron death  
Ontology : EGO-EBIserine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  nucleolus  cytoplasm  mitochondrion  endoplasmic reticulum  central nervous system development  response to wounding  regulation of neuron projection development  protein processing  protein autoprocessing  collagen catabolic process  tissue regeneration  hormone metabolic process  myelination  amyloid precursor protein metabolic process  regulation of cell differentiation  positive regulation of G-protein coupled receptor protein signaling pathway  neuron death  
NDEx NetworkKLK6
Atlas of Cancer Signalling NetworkKLK6
Wikipedia pathwaysKLK6
Orthology - Evolution
OrthoDB5653
GeneTree (enSembl)ENSG00000167755
Phylogenetic Trees/Animal Genes : TreeFamKLK6
HOVERGENQ92876
HOGENOMQ92876
Homologs : HomoloGeneKLK6
Homology/Alignments : Family Browser (UCSC)KLK6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLK6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLK6
dbVarKLK6
ClinVarKLK6
1000_GenomesKLK6 
Exome Variant ServerKLK6
ExAC (Exome Aggregation Consortium)KLK6 (select the gene name)
Genetic variants : HAPMAP5653
Genomic Variants (DGV)KLK6 [DGVbeta]
DECIPHERKLK6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLK6 
Mutations
ICGC Data PortalKLK6 
TCGA Data PortalKLK6 
Broad Tumor PortalKLK6
OASIS PortalKLK6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLK6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLK6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLK6
DgiDB (Drug Gene Interaction Database)KLK6
DoCM (Curated mutations)KLK6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLK6 (select a term)
intoGenKLK6
Cancer3DKLK6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602652   
Orphanet
MedgenKLK6
Genetic Testing Registry KLK6
NextProtQ92876 [Medical]
TSGene5653
GENETestsKLK6
Target ValidationKLK6
Huge Navigator KLK6 [HugePedia]
snp3D : Map Gene to Disease5653
BioCentury BCIQKLK6
ClinGenKLK6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5653
Chemical/Pharm GKB GenePA30156
Clinical trialKLK6
Miscellaneous
canSAR (ICR)KLK6 (select the gene name)
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLK6
EVEXKLK6
GoPubMedKLK6
iHOPKLK6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:39:50 CEST 2017

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