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KLKB1 (kallikrein B1)

Identity

Alias_namesKLK3
kallikrein B
Other aliasPKK
PKKD
PPK
HGNC (Hugo) KLKB1
LocusID (NCBI) 3818
Atlas_Id 41089
Location 4q35.2  [Link to chromosome band 4q35]
Location_base_pair Starts at 187148625 and ends at 187179628 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KLKB1   6371
Cards
Entrez_Gene (NCBI)KLKB1  3818  kallikrein B1
AliasesKLK3; PKK; PKKD; PPK
GeneCards (Weizmann)KLKB1
Ensembl hg19 (Hinxton)ENSG00000164344 [Gene_View]  chr4:187148625-187179628 [Contig_View]  KLKB1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164344 [Gene_View]  chr4:187148625-187179628 [Contig_View]  KLKB1 [Vega]
ICGC DataPortalENSG00000164344
TCGA cBioPortalKLKB1
AceView (NCBI)KLKB1
Genatlas (Paris)KLKB1
WikiGenes3818
SOURCE (Princeton)KLKB1
Genetics Home Reference (NIH)KLKB1
Genomic and cartography
GoldenPath hg19 (UCSC)KLKB1  -     chr4:187148625-187179628 +  4q35.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KLKB1  -     4q35.2   [Description]    (hg38-Dec_2013)
EnsemblKLKB1 - 4q35.2 [CytoView hg19]  KLKB1 - 4q35.2 [CytoView hg38]
Mapping of homologs : NCBIKLKB1 [Mapview hg19]  KLKB1 [Mapview hg38]
OMIM229000   612423   
Gene and transcription
Genbank (Entrez)AK292624 AK297672 AK313378 AW182528 AW471415
RefSeq transcript (Entrez)NM_000892 NM_001318394 NM_001318396
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_012095 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)KLKB1
Cluster EST : UnigeneHs.237642 [ NCBI ]
CGAP (NCI)Hs.237642
Alternative Splicing GalleryENSG00000164344
Gene ExpressionKLKB1 [ NCBI-GEO ]   KLKB1 [ EBI - ARRAY_EXPRESS ]   KLKB1 [ SEEK ]   KLKB1 [ MEM ]
Gene Expression Viewer (FireBrowse)KLKB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3818
GTEX Portal (Tissue expression)KLKB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP03952   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP03952  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP03952
Splice isoforms : SwissVarP03952
Catalytic activity : Enzyme3.4.21.34 [ Enzyme-Expasy ]   3.4.21.343.4.21.34 [ IntEnz-EBI ]   3.4.21.34 [ BRENDA ]   3.4.21.34 [ KEGG ]   
PhosPhoSitePlusP03952
Domaine pattern : Prosite (Expaxy)APPLE (PS00495)    PAN (PS50948)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Apple    Pan_app    Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)PAN_1 (PF00024)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00024    pfam00089   
Domain families : Smart (EMBL)APPLE (SM00223)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)KLKB1
DMDM Disease mutations3818
Blocks (Seattle)KLKB1
PDB (SRS)2ANW    2ANY    4OGX    4OGY    4ZJ4    4ZJ5    4ZJ6   
PDB (PDBSum)2ANW    2ANY    4OGX    4OGY    4ZJ4    4ZJ5    4ZJ6   
PDB (IMB)2ANW    2ANY    4OGX    4OGY    4ZJ4    4ZJ5    4ZJ6   
PDB (RSDB)2ANW    2ANY    4OGX    4OGY    4ZJ4    4ZJ5    4ZJ6   
Structural Biology KnowledgeBase2ANW    2ANY    4OGX    4OGY    4ZJ4    4ZJ5    4ZJ6   
SCOP (Structural Classification of Proteins)2ANW    2ANY    4OGX    4OGY    4ZJ4    4ZJ5    4ZJ6   
CATH (Classification of proteins structures)2ANW    2ANY    4OGX    4OGY    4ZJ4    4ZJ5    4ZJ6   
SuperfamilyP03952
Human Protein AtlasENSG00000164344
Peptide AtlasP03952
HPRD01971
IPIIPI00654888   IPI00966520   IPI00879718   IPI00879551   IPI00879984   IPI01010590   
Protein Interaction databases
DIP (DOE-UCLA)P03952
IntAct (EBI)P03952
FunCoupENSG00000164344
BioGRIDKLKB1
STRING (EMBL)KLKB1
ZODIACKLKB1
Ontologies - Pathways
QuickGOP03952
Ontology : AmiGOFactor XII activation  serine-type endopeptidase activity  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  proteolysis  blood coagulation, intrinsic pathway  extracellular matrix disassembly  zymogen activation  plasminogen activation  fibrinolysis  positive regulation of fibrinolysis  extracellular exosome  liver regeneration  
Ontology : EGO-EBIFactor XII activation  serine-type endopeptidase activity  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  proteolysis  blood coagulation, intrinsic pathway  extracellular matrix disassembly  zymogen activation  plasminogen activation  fibrinolysis  positive regulation of fibrinolysis  extracellular exosome  liver regeneration  
Pathways : BIOCARTAIntrinsic Prothrombin Activation Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkKLKB1
Atlas of Cancer Signalling NetworkKLKB1
Wikipedia pathwaysKLKB1
Orthology - Evolution
OrthoDB3818
GeneTree (enSembl)ENSG00000164344
Phylogenetic Trees/Animal Genes : TreeFamKLKB1
HOVERGENP03952
HOGENOMP03952
Homologs : HomoloGeneKLKB1
Homology/Alignments : Family Browser (UCSC)KLKB1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLKB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLKB1
dbVarKLKB1
ClinVarKLKB1
1000_GenomesKLKB1 
Exome Variant ServerKLKB1
ExAC (Exome Aggregation Consortium)KLKB1 (select the gene name)
Genetic variants : HAPMAP3818
Genomic Variants (DGV)KLKB1 [DGVbeta]
DECIPHER (Syndromes)4:187148625-187179628  ENSG00000164344
CONAN: Copy Number AnalysisKLKB1 
Mutations
ICGC Data PortalKLKB1 
TCGA Data PortalKLKB1 
Broad Tumor PortalKLKB1
OASIS PortalKLKB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLKB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLKB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLKB1
DgiDB (Drug Gene Interaction Database)KLKB1
DoCM (Curated mutations)KLKB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLKB1 (select a term)
intoGenKLKB1
Cancer3DKLKB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM229000    612423   
Orphanet8695   
MedgenKLKB1
Genetic Testing Registry KLKB1
NextProtP03952 [Medical]
TSGene3818
GENETestsKLKB1
Huge Navigator KLKB1 [HugePedia]
snp3D : Map Gene to Disease3818
BioCentury BCIQKLKB1
ClinGenKLKB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3818
Chemical/Pharm GKB GenePA30160
Clinical trialKLKB1
Miscellaneous
canSAR (ICR)KLKB1 (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLKB1
EVEXKLKB1
GoPubMedKLKB1
iHOPKLKB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:12:08 CET 2017

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