KLKB1 (kallikrein B1)

2003-05-01  

Identity

HGNC
LOCATION
4q35.2
LOCUSID
ALIAS
KLK3,PKK,PKKD,PPK

Other Information

Locus ID:

NCBI: 3818
MIM: 229000
HGNC: 6371
Ensembl: ENSG00000164344

Variants:

dbSNP: 3818
ClinVar: 3818
TCGA: ENSG00000164344
COSMIC: KLKB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164344ENST00000264690P03952
ENSG00000164344ENST00000428196C9J075
ENSG00000164344ENST00000446598C9JCT1
ENSG00000164344ENST00000511608H0YAC1
ENSG00000164344ENST00000513864E9PBC5

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Intrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140837
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389

References

Pubmed IDYearTitleCitations
195838182009Genetic variants associated with deep vein thrombosis: the F11 locus.28
193721412009Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women.24
161995302005Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.19
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
123728192002Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa.18
292371662018Kallikrein Cleaves C3 and Activates Complement.18
281240632017Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen.16
254774292015Genome-wide meta-analyses of plasma renin activity and concentration reveal association with the kininogen 1 and prekallikrein genes.15
179228052007Molecular modeling of the prekallikrein structure provides insights into high-molecular-weight kininogen binding and zymogen activation.14
187130092008Expression of tissue and plasma kallikreins and kinin B1 and B2 receptors in lung cancer.14

Citation

Dessen P

KLKB1 (kallikrein B1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41089/klkb1