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KLKB1 (kallikrein B1)

Identity

Alias (NCBI)KLK3
PKK
PKKD
PPK
HGNC (Hugo) KLKB1
HGNC Alias nameFletcher factor
HGNC Previous nameKLK3
HGNC Previous namekallikrein B, plasma (Fletcher factor) 1
LocusID (NCBI) 3818
Atlas_Id 41089
Location 4q35.2  [Link to chromosome band 4q35]
Location_base_pair Starts at 186227507 and ends at 186258471 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KLKB1   6371
Cards
Entrez_Gene (NCBI)KLKB1    kallikrein B1
AliasesKLK3; PKK; PKKD; PPK
GeneCards (Weizmann)KLKB1
Ensembl hg19 (Hinxton)ENSG00000164344 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164344 [Gene_View]  ENSG00000164344 [Sequence]  chr4:186227507-186258471 [Contig_View]  KLKB1 [Vega]
ICGC DataPortalENSG00000164344
TCGA cBioPortalKLKB1
AceView (NCBI)KLKB1
Genatlas (Paris)KLKB1
SOURCE (Princeton)KLKB1
Genetics Home Reference (NIH)KLKB1
Genomic and cartography
GoldenPath hg38 (UCSC)KLKB1  -     chr4:186227507-186258471 +  4q35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLKB1  -     4q35.2   [Description]    (hg19-Feb_2009)
GoldenPathKLKB1 - 4q35.2 [CytoView hg19]  KLKB1 - 4q35.2 [CytoView hg38]
ImmunoBaseENSG00000164344
Genome Data Viewer NCBIKLKB1 [Mapview hg19]  
OMIM229000   612423   
Gene and transcription
Genbank (Entrez)AK292624 AK297672 AK313378 AW182528 AW471415
RefSeq transcript (Entrez)NM_000892 NM_001318394 NM_001318396
Consensus coding sequences : CCDS (NCBI)KLKB1
Gene ExpressionKLKB1 [ NCBI-GEO ]   KLKB1 [ EBI - ARRAY_EXPRESS ]   KLKB1 [ SEEK ]   KLKB1 [ MEM ]
Gene Expression Viewer (FireBrowse)KLKB1 [ Firebrowse - Broad ]
GenevisibleExpression of KLKB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3818
GTEX Portal (Tissue expression)KLKB1
Human Protein AtlasENSG00000164344-KLKB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP03952   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP03952  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP03952
Catalytic activity : Enzyme3.4.21.34 [ Enzyme-Expasy ]   3.4.21.343.4.21.34 [ IntEnz-EBI ]   3.4.21.34 [ BRENDA ]   3.4.21.34 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP03952
Domaine pattern : Prosite (Expaxy)APPLE (PS00495)    PAN (PS50948)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Apple    Pan_app    Peptidase_S1_PA    Peptidase_S1_PA_chymotrypsin    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)PAN_1 (PF00024)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00024    pfam00089   
Domain families : Smart (EMBL)APPLE (SM00223)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)KLKB1
PDB (RSDB)2ANW    2ANY    4OGX    4OGY    5F8T    5F8X    5F8Z    5TJX    6I44    6O1G    6O1S    6T7P   
PDB Europe2ANW    2ANY    4OGX    4OGY    5F8T    5F8X    5F8Z    5TJX    6I44    6O1G    6O1S    6T7P   
PDB (PDBSum)2ANW    2ANY    4OGX    4OGY    5F8T    5F8X    5F8Z    5TJX    6I44    6O1G    6O1S    6T7P   
PDB (IMB)2ANW    2ANY    4OGX    4OGY    5F8T    5F8X    5F8Z    5TJX    6I44    6O1G    6O1S    6T7P   
Structural Biology KnowledgeBase2ANW    2ANY    4OGX    4OGY    5F8T    5F8X    5F8Z    5TJX    6I44    6O1G    6O1S    6T7P   
SCOP (Structural Classification of Proteins)2ANW    2ANY    4OGX    4OGY    5F8T    5F8X    5F8Z    5TJX    6I44    6O1G    6O1S    6T7P   
CATH (Classification of proteins structures)2ANW    2ANY    4OGX    4OGY    5F8T    5F8X    5F8Z    5TJX    6I44    6O1G    6O1S    6T7P   
SuperfamilyP03952
AlphaFold pdb e-kbP03952   
Human Protein Atlas [tissue]ENSG00000164344-KLKB1 [tissue]
HPRD01971
Protein Interaction databases
DIP (DOE-UCLA)P03952
IntAct (EBI)P03952
BioGRIDKLKB1
STRING (EMBL)KLKB1
ZODIACKLKB1
Ontologies - Pathways
QuickGOP03952
Ontology : AmiGOFactor XII activation  serine-type endopeptidase activity  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  proteolysis  blood coagulation, intrinsic pathway  extracellular matrix disassembly  zymogen activation  plasminogen activation  fibrinolysis  positive regulation of fibrinolysis  extracellular exosome  negative regulation of blood coagulation, intrinsic pathway  
Ontology : EGO-EBIFactor XII activation  serine-type endopeptidase activity  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  proteolysis  blood coagulation, intrinsic pathway  extracellular matrix disassembly  zymogen activation  plasminogen activation  fibrinolysis  positive regulation of fibrinolysis  extracellular exosome  negative regulation of blood coagulation, intrinsic pathway  
Pathways : BIOCARTAIntrinsic Prothrombin Activation Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkKLKB1
Atlas of Cancer Signalling NetworkKLKB1
Wikipedia pathwaysKLKB1
Orthology - Evolution
OrthoDB3818
GeneTree (enSembl)ENSG00000164344
Phylogenetic Trees/Animal Genes : TreeFamKLKB1
Homologs : HomoloGeneKLKB1
Homology/Alignments : Family Browser (UCSC)KLKB1
Gene fusions - Rearrangements
Fusion : QuiverKLKB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLKB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLKB1
dbVarKLKB1
ClinVarKLKB1
MonarchKLKB1
1000_GenomesKLKB1 
Exome Variant ServerKLKB1
GNOMAD BrowserENSG00000164344
Varsome BrowserKLKB1
ACMGKLKB1 variants
VarityP03952
Genomic Variants (DGV)KLKB1 [DGVbeta]
DECIPHERKLKB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLKB1 
Mutations
ICGC Data PortalKLKB1 
TCGA Data PortalKLKB1 
Broad Tumor PortalKLKB1
OASIS PortalKLKB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLKB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKLKB1
Mutations and Diseases : HGMDKLKB1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKLKB1
DgiDB (Drug Gene Interaction Database)KLKB1
DoCM (Curated mutations)KLKB1
CIViC (Clinical Interpretations of Variants in Cancer)KLKB1
Cancer3DKLKB1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM229000    612423   
Orphanet8695   
DisGeNETKLKB1
MedgenKLKB1
Genetic Testing Registry KLKB1
NextProtP03952 [Medical]
GENETestsKLKB1
Target ValidationKLKB1
Huge Navigator KLKB1 [HugePedia]
ClinGenKLKB1
Clinical trials, drugs, therapy
MyCancerGenomeKLKB1
Protein Interactions : CTDKLKB1
Pharm GKB GenePA30160
PharosP03952
Clinical trialKLKB1
Miscellaneous
canSAR (ICR)KLKB1
HarmonizomeKLKB1
ARCHS4KLKB1
DataMed IndexKLKB1
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKLKB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sun Jan 16 18:17:00 CET 2022

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