KLRB1 (killer cell lectin like receptor B1)

2007-02-01  

Identity

HGNC
KLRB1
LOCATION
12p13.31
LOCUSID
3820
ALIAS
CD161,CLEC5B,NKR,NKR-P1,NKR-P1A,NKRP1A,hNKR-P1A

Other Information

Locus ID:

NCBI: 3820
MIM: 602890
HGNC: 6373
Ensembl: ENSG00000111796

Variants:

dbSNP: 3820
ClinVar: 3820
TCGA: ENSG00000111796
COSMIC: KLRB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111796ENST00000229402Q12918

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MalariaKEGGko05144
MalariaKEGGhsa05144
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
219090912011Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.372
186631282008Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.255
192736242009Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation.154
201336072010Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties.129
204861232010CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC.127
254375612014CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.91
163395122005Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor.83
163395132005Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor.83
184535692008Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells.58
233555382013CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines.56

Citation

Dessen P

KLRB1 (killer cell lectin like receptor B1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50012/klrb1