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KLRC1 (killer cell lectin like receptor C1)

Identity

Alias (NCBI)CD159A
NKG2
NKG2A
HGNC (Hugo) KLRC1
HGNC Alias symbNKG2-A
NKG2-B
CD159a
HGNC Alias nameNKG2-1/B activating NK receptor
HGNC Previous nameNKG2
HGNC Previous namekiller cell lectin-like receptor subfamily C, member 1
LocusID (NCBI) 3821
Atlas_Id 41090
Location 12p13.2  [Link to chromosome band 12p13]
Location_base_pair Starts at 10446036 and ends at 10454616 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KLRC1   6374
Cards
Entrez_Gene (NCBI)KLRC1    killer cell lectin like receptor C1
AliasesCD159A; NKG2; NKG2A
GeneCards (Weizmann)KLRC1
Ensembl hg19 (Hinxton)ENSG00000134545 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134545 [Gene_View]  ENSG00000134545 [Sequence]  chr12:10446036-10454616 [Contig_View]  KLRC1 [Vega]
ICGC DataPortalENSG00000134545
TCGA cBioPortalKLRC1
AceView (NCBI)KLRC1
Genatlas (Paris)KLRC1
SOURCE (Princeton)KLRC1
Genetics Home Reference (NIH)KLRC1
Genomic and cartography
GoldenPath hg38 (UCSC)KLRC1  -     chr12:10446036-10454616 -  12p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLRC1  -     12p13.2   [Description]    (hg19-Feb_2009)
GoldenPathKLRC1 - 12p13.2 [CytoView hg19]  KLRC1 - 12p13.2 [CytoView hg38]
ImmunoBaseENSG00000134545
Genome Data Viewer NCBIKLRC1 [Mapview hg19]  
OMIM161555   
Gene and transcription
Genbank (Entrez)AF461812 AK310992 BC012550 BC053840 DB464226
RefSeq transcript (Entrez)NM_001304448 NM_002259 NM_007328 NM_213657 NM_213658
Consensus coding sequences : CCDS (NCBI)KLRC1
Gene ExpressionKLRC1 [ NCBI-GEO ]   KLRC1 [ EBI - ARRAY_EXPRESS ]   KLRC1 [ SEEK ]   KLRC1 [ MEM ]
Gene Expression Viewer (FireBrowse)KLRC1 [ Firebrowse - Broad ]
GenevisibleExpression of KLRC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3821
GTEX Portal (Tissue expression)KLRC1
Human Protein AtlasENSG00000134545-KLRC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26715   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26715  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26715
PhosPhoSitePlusP26715
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_2 (PS50041)   
Domains : Interpro (EBI)C-type_lectin-like    C-type_lectin-like/link_sf    CTDL_fold    NKR-like_CTLD   
Domain families : Pfam (Sanger)Lectin_C (PF00059)   
Domain families : Pfam (NCBI)pfam00059   
Domain families : Smart (EMBL)CLECT (SM00034)  
Conserved Domain (NCBI)KLRC1
PDB (RSDB)2RMX    2YU7    3BDW    3CDG    3CII   
PDB Europe2RMX    2YU7    3BDW    3CDG    3CII   
PDB (PDBSum)2RMX    2YU7    3BDW    3CDG    3CII   
PDB (IMB)2RMX    2YU7    3BDW    3CDG    3CII   
Structural Biology KnowledgeBase2RMX    2YU7    3BDW    3CDG    3CII   
SCOP (Structural Classification of Proteins)2RMX    2YU7    3BDW    3CDG    3CII   
CATH (Classification of proteins structures)2RMX    2YU7    3BDW    3CDG    3CII   
SuperfamilyP26715
AlphaFold pdb e-kbP26715   
Human Protein Atlas [tissue]ENSG00000134545-KLRC1 [tissue]
HPRD01192
Protein Interaction databases
DIP (DOE-UCLA)P26715
IntAct (EBI)P26715
BioGRIDKLRC1
STRING (EMBL)KLRC1
ZODIACKLRC1
Ontologies - Pathways
QuickGOP26715
Ontology : AmiGOnegative regulation of T cell mediated cytotoxicity  adaptive immune response  CD8-positive, gamma-delta intraepithelial T cell differentiation  natural killer cell inhibitory signaling pathway  transmembrane signaling receptor activity  protein binding  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  MHC class I protein complex binding  carbohydrate binding  receptor complex  innate immune response  negative regulation of natural killer cell mediated cytotoxicity  regulation of immune response  HLA-E specific inhibitory MHC class Ib receptor activity  protein antigen binding  
Ontology : EGO-EBInegative regulation of T cell mediated cytotoxicity  adaptive immune response  CD8-positive, gamma-delta intraepithelial T cell differentiation  natural killer cell inhibitory signaling pathway  transmembrane signaling receptor activity  protein binding  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  MHC class I protein complex binding  carbohydrate binding  receptor complex  innate immune response  negative regulation of natural killer cell mediated cytotoxicity  regulation of immune response  HLA-E specific inhibitory MHC class Ib receptor activity  protein antigen binding  
Pathways : BIOCARTARas-Independent pathway in NK cell-mediated cytotoxicity [Genes]   
Pathways : KEGGAntigen processing and presentation    Natural killer cell mediated cytotoxicity    Graft-versus-host disease   
NDEx NetworkKLRC1
Atlas of Cancer Signalling NetworkKLRC1
Wikipedia pathwaysKLRC1
Orthology - Evolution
OrthoDB3821
GeneTree (enSembl)ENSG00000134545
Phylogenetic Trees/Animal Genes : TreeFamKLRC1
Homologs : HomoloGeneKLRC1
Homology/Alignments : Family Browser (UCSC)KLRC1
Gene fusions - Rearrangements
Fusion : QuiverKLRC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLRC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLRC1
dbVarKLRC1
ClinVarKLRC1
MonarchKLRC1
1000_GenomesKLRC1 
Exome Variant ServerKLRC1
GNOMAD BrowserENSG00000134545
Varsome BrowserKLRC1
ACMGKLRC1 variants
VarityP26715
Genomic Variants (DGV)KLRC1 [DGVbeta]
DECIPHERKLRC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLRC1 
Mutations
ICGC Data PortalKLRC1 
TCGA Data PortalKLRC1 
Broad Tumor PortalKLRC1
OASIS PortalKLRC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLRC1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKLRC1
Mutations and Diseases : HGMDKLRC1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKLRC1
DgiDB (Drug Gene Interaction Database)KLRC1
DoCM (Curated mutations)KLRC1
CIViC (Clinical Interpretations of Variants in Cancer)KLRC1
Cancer3DKLRC1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM161555   
Orphanet
DisGeNETKLRC1
MedgenKLRC1
Genetic Testing Registry KLRC1
NextProtP26715 [Medical]
GENETestsKLRC1
Target ValidationKLRC1
Huge Navigator KLRC1 [HugePedia]
ClinGenKLRC1
Clinical trials, drugs, therapy
MyCancerGenomeKLRC1
Protein Interactions : CTDKLRC1
Pharm GKB GenePA30163
PharosP26715
Clinical trialKLRC1
Miscellaneous
canSAR (ICR)KLRC1
HarmonizomeKLRC1
DataMed IndexKLRC1
Probes
Litterature
PubMed85 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKLRC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:15:15 CEST 2021

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