KLRC2 (killer cell lectin like receptor C2)

2003-06-01  

Identity

HGNC
LOCATION
12p13.2
LOCUSID
ALIAS
CD159c,NKG2-C,NKG2C

Other Information

Locus ID:

NCBI: 3822
MIM: 602891
HGNC: 6375
Ensembl: ENSG00000205809

Variants:

dbSNP: 3822
ClinVar: 3822
TCGA: ENSG00000205809
COSMIC: KLRC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205809ENST00000381901J3KPJ4
ENSG00000205809ENST00000381902P26717
ENSG00000205809ENST00000535069H0YFK4
ENSG00000205809ENST00000536833F5H518
ENSG00000205809ENST00000537017H0YGY2
ENSG00000205809ENST00000619500A0A087WV37

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Natural killer cell mediated cytotoxicityKEGGko04650
Antigen processing and presentationKEGGhsa04612
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491

References

Pubmed IDYearTitleCitations
379012272023Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells.0
379012272023Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells.0
349904062022Donor NKG2C homozygosity contributes to CMV clearance after haploidentical transplantation.7
353147642022Assessment of NKG2C copy number variation in HIV-1 infection susceptibility, and considerations about the potential role of lacking receptors and virus infection.3
356286682022NKG2C+ NK Cells for Immunotherapy of Glioblastoma Multiforme.8
358023532022Diversity of NKG2C genotypes in a European population: Conserved and recombinant haplotypes in the coding, promoter, and 3'-untranslated regions.2
349904062022Donor NKG2C homozygosity contributes to CMV clearance after haploidentical transplantation.7
353147642022Assessment of NKG2C copy number variation in HIV-1 infection susceptibility, and considerations about the potential role of lacking receptors and virus infection.3
356286682022NKG2C+ NK Cells for Immunotherapy of Glioblastoma Multiforme.8
358023532022Diversity of NKG2C genotypes in a European population: Conserved and recombinant haplotypes in the coding, promoter, and 3'-untranslated regions.2
335005682021Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19.68
336157292021Reduced expansion of CD94/NKG2C(+) NK cells in chronic lymphocytic leukemia and CLL-like monoclonal B-cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions.6
340764842021Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point.8
349481232021Increased Susceptibility of the CD57(-) NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response.1
335005682021Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19.68

Citation

Dessen P

KLRC2 (killer cell lectin like receptor C2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41091/klrc2