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KLRC2 (killer cell lectin like receptor C2)

Identity

Alias (NCBI)CD159c
NKG2-C
NKG2C
HGNC (Hugo) KLRC2
HGNC Alias symbNKG2-C
CD159c
NKG2C
HGNC Alias nameNKG2-C type II integral membrane protein
 natural killer cell receptor G2-C
HGNC Previous namekiller cell lectin-like receptor subfamily C, member 2
LocusID (NCBI) 3822
Atlas_Id 41091
Location 12p13.2  [Link to chromosome band 12p13]
Location_base_pair Starts at 10430606 and ends at 10435993 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KLRC2   6375
Cards
Entrez_Gene (NCBI)KLRC2    killer cell lectin like receptor C2
AliasesCD159c; NKG2-C; NKG2C
GeneCards (Weizmann)KLRC2
Ensembl hg19 (Hinxton)ENSG00000205809 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000205809 [Gene_View]  ENSG00000205809 [Sequence]  chr12:10430606-10435993 [Contig_View]  KLRC2 [Vega]
ICGC DataPortalENSG00000205809
TCGA cBioPortalKLRC2
AceView (NCBI)KLRC2
Genatlas (Paris)KLRC2
SOURCE (Princeton)KLRC2
Genetics Home Reference (NIH)KLRC2
Genomic and cartography
GoldenPath hg38 (UCSC)KLRC2  -     chr12:10430606-10435993 -  12p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLRC2  -     12p13.2   [Description]    (hg19-Feb_2009)
GoldenPathKLRC2 - 12p13.2 [CytoView hg19]  KLRC2 - 12p13.2 [CytoView hg38]
ImmunoBaseENSG00000205809
Genome Data Viewer NCBIKLRC2 [Mapview hg19]  
OMIM602891   
Gene and transcription
Genbank (Entrez)AF260134 AK295525 BC093644 BC106069 BC112039
RefSeq transcript (Entrez)NM_002260
Consensus coding sequences : CCDS (NCBI)KLRC2
Gene ExpressionKLRC2 [ NCBI-GEO ]   KLRC2 [ EBI - ARRAY_EXPRESS ]   KLRC2 [ SEEK ]   KLRC2 [ MEM ]
Gene Expression Viewer (FireBrowse)KLRC2 [ Firebrowse - Broad ]
GenevisibleExpression of KLRC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3822
GTEX Portal (Tissue expression)KLRC2
Human Protein AtlasENSG00000205809-KLRC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26717   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26717  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26717
PhosPhoSitePlusP26717
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_2 (PS50041)   
Domains : Interpro (EBI)C-type_lectin-like    C-type_lectin-like/link_sf    CTDL_fold    NKR-like_CTLD   
Domain families : Pfam (Sanger)Lectin_C (PF00059)   
Domain families : Pfam (NCBI)pfam00059   
Domain families : Smart (EMBL)CLECT (SM00034)  
Conserved Domain (NCBI)KLRC2
PDB (RSDB)2L35   
PDB Europe2L35   
PDB (PDBSum)2L35   
PDB (IMB)2L35   
Structural Biology KnowledgeBase2L35   
SCOP (Structural Classification of Proteins)2L35   
CATH (Classification of proteins structures)2L35   
SuperfamilyP26717
AlphaFold pdb e-kbP26717   
Human Protein Atlas [tissue]ENSG00000205809-KLRC2 [tissue]
HPRD04202
Protein Interaction databases
DIP (DOE-UCLA)P26717
IntAct (EBI)P26717
BioGRIDKLRC2
STRING (EMBL)KLRC2
ZODIACKLRC2
Ontologies - Pathways
QuickGOP26717
Ontology : AmiGOstimulatory C-type lectin receptor signaling pathway  natural killer cell mediated immunity  adaptive immune response  transmembrane signaling receptor activity  protein binding  plasma membrane  integral component of plasma membrane  cellular defense response  signal transduction  MHC class I protein complex binding  carbohydrate binding  receptor complex  positive regulation of natural killer cell degranulation  innate immune response  positive regulation of natural killer cell mediated cytotoxicity  activating MHC class Ib receptor activity  protein antigen binding  
Ontology : EGO-EBIstimulatory C-type lectin receptor signaling pathway  natural killer cell mediated immunity  adaptive immune response  transmembrane signaling receptor activity  protein binding  plasma membrane  integral component of plasma membrane  cellular defense response  signal transduction  MHC class I protein complex binding  carbohydrate binding  receptor complex  positive regulation of natural killer cell degranulation  innate immune response  positive regulation of natural killer cell mediated cytotoxicity  activating MHC class Ib receptor activity  protein antigen binding  
Pathways : BIOCARTARas-Independent pathway in NK cell-mediated cytotoxicity [Genes]   
Pathways : KEGGAntigen processing and presentation    Natural killer cell mediated cytotoxicity   
NDEx NetworkKLRC2
Atlas of Cancer Signalling NetworkKLRC2
Wikipedia pathwaysKLRC2
Orthology - Evolution
OrthoDB3822
GeneTree (enSembl)ENSG00000205809
Phylogenetic Trees/Animal Genes : TreeFamKLRC2
Homologs : HomoloGeneKLRC2
Homology/Alignments : Family Browser (UCSC)KLRC2
Gene fusions - Rearrangements
Fusion : QuiverKLRC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLRC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLRC2
dbVarKLRC2
ClinVarKLRC2
MonarchKLRC2
1000_GenomesKLRC2 
Exome Variant ServerKLRC2
GNOMAD BrowserENSG00000205809
Varsome BrowserKLRC2
ACMGKLRC2 variants
VarityP26717
Genomic Variants (DGV)KLRC2 [DGVbeta]
DECIPHERKLRC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLRC2 
Mutations
ICGC Data PortalKLRC2 
TCGA Data PortalKLRC2 
Broad Tumor PortalKLRC2
OASIS PortalKLRC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLRC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKLRC2
Mutations and Diseases : HGMDKLRC2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKLRC2
DgiDB (Drug Gene Interaction Database)KLRC2
DoCM (Curated mutations)KLRC2
CIViC (Clinical Interpretations of Variants in Cancer)KLRC2
Cancer3DKLRC2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602891   
Orphanet
DisGeNETKLRC2
MedgenKLRC2
Genetic Testing Registry KLRC2
NextProtP26717 [Medical]
GENETestsKLRC2
Target ValidationKLRC2
Huge Navigator KLRC2 [HugePedia]
ClinGenKLRC2
Clinical trials, drugs, therapy
MyCancerGenomeKLRC2
Protein Interactions : CTDKLRC2
Pharm GKB GenePA30164
PharosP26717
Clinical trialKLRC2
Miscellaneous
canSAR (ICR)KLRC2
HarmonizomeKLRC2
DataMed IndexKLRC2
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKLRC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:15:15 CEST 2021

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