KLRD1 (killer cell lectin like receptor D1)

2011-04-01  

Identity

HGNC
LOCATION
12p13.2
LOCUSID
ALIAS
CD94

Other Information

Locus ID:

NCBI: 3824
MIM: 602894
HGNC: 6378
Ensembl: ENSG00000134539

Variants:

dbSNP: 3824
ClinVar: 3824
TCGA: ENSG00000134539
COSMIC: KLRD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134539ENST00000336164Q13241
ENSG00000134539ENST00000344825E9PCX9
ENSG00000134539ENST00000350274Q13241
ENSG00000134539ENST00000381908Q13241
ENSG00000134539ENST00000539374F5GX94
ENSG00000134539ENST00000539792H0YFB8
ENSG00000134539ENST00000543420F5GX94
ENSG00000134539ENST00000543777F6WZH4
ENSG00000134539ENST00000544747F5H2B7

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Natural killer cell mediated cytotoxicityKEGGko04650
Graft-versus-host diseaseKEGGko05332
Antigen processing and presentationKEGGhsa04612
Natural killer cell mediated cytotoxicityKEGGhsa04650
Graft-versus-host diseaseKEGGhsa05332
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10004adalimumabChemicalClinicalAnnotationassociatedPD26453102
PA165107055certolizumab pegolChemicalClinicalAnnotationassociatedPD26453102
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD26453102
PA449515etanerceptChemicalClinicalAnnotationassociatedPD26453102
PA450428methotrexateChemicalClinicalAnnotationassociatedPD26453102
PA452347glucocorticoidsChemicalClinicalAnnotationassociatedPD26453102
PA452639infliximabChemicalClinicalAnnotationassociatedPD26453102

References

Pubmed IDYearTitleCitations
198975772010CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets.93
155283432004Negative regulation of NK cell activities by inhibitory receptor CD94/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection.76
183321822008CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.67
124610762002A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.65
184486742008Structural basis for NKG2A/CD94 recognition of HLA-E.65
223841142012Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A.62
123877422002TCR specificity dictates CD94/NKG2A expression by human CTL.40
240306382013NKG2C zygosity influences CD94/NKG2C receptor function and the NK-cell compartment redistribution in response to human cytomegalovirus.32
179763182007High expression of NKG2A/CD94 and low expression of granzyme B are associated with reduced cord blood NK cell activity.30
117519682002Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.29

Citation

Dessen P

KLRD1 (killer cell lectin like receptor D1)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52201/klrd1