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KMO (kynurenine 3-monooxygenase (kynurenine 3-hydroxylase))

Identity

Alias_nameskynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Other aliasdJ317G22.1
HGNC (Hugo) KMO
LocusID (NCBI) 8564
Atlas_Id 55782
Location 1q43  [Link to chromosome band 1q43]
Location_base_pair Starts at 241695434 and ends at 241758949 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KMO (1q43) / MALAT1 (11q13.1)NME7 (1q24.2) / KMO (1q43)PSTPIP2 (18q21.1) / KMO (1q43)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KMO   6381
Cards
Entrez_Gene (NCBI)KMO  8564  kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
AliasesdJ317G22.1
GeneCards (Weizmann)KMO
Ensembl hg19 (Hinxton)ENSG00000117009 [Gene_View]  chr1:241695434-241758949 [Contig_View]  KMO [Vega]
Ensembl hg38 (Hinxton)ENSG00000117009 [Gene_View]  chr1:241695434-241758949 [Contig_View]  KMO [Vega]
ICGC DataPortalENSG00000117009
TCGA cBioPortalKMO
AceView (NCBI)KMO
Genatlas (Paris)KMO
WikiGenes8564
SOURCE (Princeton)KMO
Genetics Home Reference (NIH)KMO
Genomic and cartography
GoldenPath hg19 (UCSC)KMO  -     chr1:241695434-241758949 +  1q43   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KMO  -     1q43   [Description]    (hg38-Dec_2013)
EnsemblKMO - 1q43 [CytoView hg19]  KMO - 1q43 [CytoView hg38]
Mapping of homologs : NCBIKMO [Mapview hg19]  KMO [Mapview hg38]
OMIM603538   
Gene and transcription
Genbank (Entrez)AF056032 AI262990 AK291558 AK310937 AU137977
RefSeq transcript (Entrez)NM_003679
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_167186 NW_004929294
Consensus coding sequences : CCDS (NCBI)KMO
Cluster EST : UnigeneHs.744065 [ NCBI ]
CGAP (NCI)Hs.744065
Alternative Splicing GalleryENSG00000117009
Gene ExpressionKMO [ NCBI-GEO ]   KMO [ EBI - ARRAY_EXPRESS ]   KMO [ SEEK ]   KMO [ MEM ]
Gene Expression Viewer (FireBrowse)KMO [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8564
GTEX Portal (Tissue expression)KMO
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15229   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15229  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15229
Splice isoforms : SwissVarO15229
PhosPhoSitePlusO15229
Domains : Interpro (EBI)FAD-bd    FAD/NAD-binding_dom    Kynurenine_monooxygenase   
Domain families : Pfam (Sanger)FAD_binding_3 (PF01494)   
Domain families : Pfam (NCBI)pfam01494   
Conserved Domain (NCBI)KMO
DMDM Disease mutations8564
Blocks (Seattle)KMO
SuperfamilyO15229
Human Protein AtlasENSG00000117009
Peptide AtlasO15229
HPRD04642
IPIIPI00642771   IPI00645486   IPI00515018   IPI00791630   
Protein Interaction databases
DIP (DOE-UCLA)O15229
IntAct (EBI)O15229
FunCoupENSG00000117009
BioGRIDKMO
STRING (EMBL)KMO
ZODIACKMO
Ontologies - Pathways
QuickGOO15229
Ontology : AmiGOkynurenine 3-monooxygenase activity  kynurenine 3-monooxygenase activity  mitochondrial outer membrane  mitochondrial inner membrane  cytosol  tryptophan catabolic process  response to salt stress  integral component of membrane  NAD(P)H oxidase activity  tryptophan catabolic process to kynurenine  NAD metabolic process  quinolinate biosynthetic process  'de novo' NAD biosynthetic process from tryptophan  anthranilate metabolic process  secondary metabolite biosynthetic process  flavin adenine dinucleotide binding  oxidation-reduction process  extracellular exosome  kynurenine metabolic process  FAD binding  
Ontology : EGO-EBIkynurenine 3-monooxygenase activity  kynurenine 3-monooxygenase activity  mitochondrial outer membrane  mitochondrial inner membrane  cytosol  tryptophan catabolic process  response to salt stress  integral component of membrane  NAD(P)H oxidase activity  tryptophan catabolic process to kynurenine  NAD metabolic process  quinolinate biosynthetic process  'de novo' NAD biosynthetic process from tryptophan  anthranilate metabolic process  secondary metabolite biosynthetic process  flavin adenine dinucleotide binding  oxidation-reduction process  extracellular exosome  kynurenine metabolic process  FAD binding  
Pathways : KEGGTryptophan metabolism   
NDEx NetworkKMO
Atlas of Cancer Signalling NetworkKMO
Wikipedia pathwaysKMO
Orthology - Evolution
OrthoDB8564
GeneTree (enSembl)ENSG00000117009
Phylogenetic Trees/Animal Genes : TreeFamKMO
HOVERGENO15229
HOGENOMO15229
Homologs : HomoloGeneKMO
Homology/Alignments : Family Browser (UCSC)KMO
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKMO [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KMO
dbVarKMO
ClinVarKMO
1000_GenomesKMO 
Exome Variant ServerKMO
ExAC (Exome Aggregation Consortium)KMO (select the gene name)
Genetic variants : HAPMAP8564
Genomic Variants (DGV)KMO [DGVbeta]
DECIPHER (Syndromes)1:241695434-241758949  ENSG00000117009
CONAN: Copy Number AnalysisKMO 
Mutations
ICGC Data PortalKMO 
TCGA Data PortalKMO 
Broad Tumor PortalKMO
OASIS PortalKMO [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKMO  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKMO
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KMO
DgiDB (Drug Gene Interaction Database)KMO
DoCM (Curated mutations)KMO (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KMO (select a term)
intoGenKMO
Cancer3DKMO(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603538   
Orphanet
MedgenKMO
Genetic Testing Registry KMO
NextProtO15229 [Medical]
TSGene8564
GENETestsKMO
Huge Navigator KMO [HugePedia]
snp3D : Map Gene to Disease8564
BioCentury BCIQKMO
ClinGenKMO
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8564
Chemical/Pharm GKB GenePA30172
Clinical trialKMO
Miscellaneous
canSAR (ICR)KMO (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKMO
EVEXKMO
GoPubMedKMO
iHOPKMO
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:12:10 CET 2017

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