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KMT5B (lysine methyltransferase 5B)

Identity

Alias_namesSUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
lysine (K)-specific methyltransferase 5B
Alias_symbol (synonym)CGI-85
Other aliasCGI85
HGNC (Hugo) KMT5B
LocusID (NCBI) 51111
Atlas_Id 77843
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 68154863 and ends at 68213345 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KMT5B (11q13.2) / CATSPER1 (11q13.1)KMT5B (11q13.2) / COX4I1 (16q24.1)KMT5B (11q13.2) / KMT5B (11q13.2)
KMT5B (11q13.2) / MTL5 (11q13.3)KMT5B (11q13.2) / MYO1D (17q11.2)KMT5B (11q13.2) / PNP (14q11.2)
KMT5B (11q13.2) / SLITRK4 (Xq27.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KMT5B   24283
Cards
Entrez_Gene (NCBI)KMT5B  51111  lysine methyltransferase 5B
AliasesCGI-85; CGI85; SUV420H1
GeneCards (Weizmann)KMT5B
Ensembl hg19 (Hinxton)ENSG00000110066 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110066 [Gene_View]  chr11:68154863-68213345 [Contig_View]  KMT5B [Vega]
ICGC DataPortalENSG00000110066
TCGA cBioPortalKMT5B
AceView (NCBI)KMT5B
Genatlas (Paris)KMT5B
WikiGenes51111
SOURCE (Princeton)KMT5B
Genetics Home Reference (NIH)KMT5B
Genomic and cartography
GoldenPath hg38 (UCSC)KMT5B  -     chr11:68154863-68213345 -  11q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KMT5B  -     11q13.2   [Description]    (hg19-Feb_2009)
EnsemblKMT5B - 11q13.2 [CytoView hg19]  KMT5B - 11q13.2 [CytoView hg38]
Mapping of homologs : NCBIKMT5B [Mapview hg19]  KMT5B [Mapview hg38]
OMIM610881   
Gene and transcription
Genbank (Entrez)AF151843 AF264782 AI659791 AK000046 AK025183
RefSeq transcript (Entrez)NM_001300907 NM_001300908 NM_001300909 NM_016028 NM_017635
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KMT5B
Cluster EST : UnigeneHs.632120 [ NCBI ]
CGAP (NCI)Hs.632120
Alternative Splicing GalleryENSG00000110066
Gene ExpressionKMT5B [ NCBI-GEO ]   KMT5B [ EBI - ARRAY_EXPRESS ]   KMT5B [ SEEK ]   KMT5B [ MEM ]
Gene Expression Viewer (FireBrowse)KMT5B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51111
GTEX Portal (Tissue expression)KMT5B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4FZB7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4FZB7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4FZB7
Splice isoforms : SwissVarQ4FZB7
Catalytic activity : Enzyme2.1.1.43 [ Enzyme-Expasy ]   2.1.1.432.1.1.43 [ IntEnz-EBI ]   2.1.1.43 [ BRENDA ]   2.1.1.43 [ KEGG ]   
PhosPhoSitePlusQ4FZB7
Domaine pattern : Prosite (Expaxy)SAM_MT43_SUVAR420_2 (PS51570)    SET (PS50280)   
Domains : Interpro (EBI)Hist-Lys_N-MTase_Suvar4-20    SET_dom   
Domain families : Pfam (Sanger)SET (PF00856)   
Domain families : Pfam (NCBI)pfam00856   
Domain families : Smart (EMBL)SET (SM00317)  
Conserved Domain (NCBI)KMT5B
DMDM Disease mutations51111
Blocks (Seattle)KMT5B
PDB (SRS)3S8P    5CPR   
PDB (PDBSum)3S8P    5CPR   
PDB (IMB)3S8P    5CPR   
PDB (RSDB)3S8P    5CPR   
Structural Biology KnowledgeBase3S8P    5CPR   
SCOP (Structural Classification of Proteins)3S8P    5CPR   
CATH (Classification of proteins structures)3S8P    5CPR   
SuperfamilyQ4FZB7
Human Protein AtlasENSG00000110066
Peptide AtlasQ4FZB7
HPRD11616
IPIIPI00329708   IPI00455177   IPI00879841   IPI00878261   IPI00878622   IPI00844368   IPI00974435   IPI00878771   IPI00879308   IPI00385854   IPI01013656   
Protein Interaction databases
DIP (DOE-UCLA)Q4FZB7
IntAct (EBI)Q4FZB7
FunCoupENSG00000110066
BioGRIDKMT5B
STRING (EMBL)KMT5B
ZODIACKMT5B
Ontologies - Pathways
QuickGOQ4FZB7
Ontology : AmiGOcondensed nuclear chromosome, centromeric region  nucleus  nucleoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  muscle organ development  histone-lysine N-methyltransferase activity  histone-lysine N-methyltransferase activity  histone H4-K20 trimethylation  histone methyltransferase activity (H4-K20 specific)  
Ontology : EGO-EBIcondensed nuclear chromosome, centromeric region  nucleus  nucleoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  muscle organ development  histone-lysine N-methyltransferase activity  histone-lysine N-methyltransferase activity  histone H4-K20 trimethylation  histone methyltransferase activity (H4-K20 specific)  
NDEx NetworkKMT5B
Atlas of Cancer Signalling NetworkKMT5B
Wikipedia pathwaysKMT5B
Orthology - Evolution
OrthoDB51111
GeneTree (enSembl)ENSG00000110066
Phylogenetic Trees/Animal Genes : TreeFamKMT5B
HOVERGENQ4FZB7
HOGENOMQ4FZB7
Homologs : HomoloGeneKMT5B
Homology/Alignments : Family Browser (UCSC)KMT5B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKMT5B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KMT5B
dbVarKMT5B
ClinVarKMT5B
1000_GenomesKMT5B 
Exome Variant ServerKMT5B
ExAC (Exome Aggregation Consortium)KMT5B (select the gene name)
Genetic variants : HAPMAP51111
Genomic Variants (DGV)KMT5B [DGVbeta]
DECIPHERKMT5B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKMT5B 
Mutations
ICGC Data PortalKMT5B 
TCGA Data PortalKMT5B 
Broad Tumor PortalKMT5B
OASIS PortalKMT5B [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDKMT5B
BioMutasearch KMT5B
DgiDB (Drug Gene Interaction Database)KMT5B
DoCM (Curated mutations)KMT5B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KMT5B (select a term)
intoGenKMT5B
Cancer3DKMT5B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610881   
Orphanet
MedgenKMT5B
Genetic Testing Registry KMT5B
NextProtQ4FZB7 [Medical]
TSGene51111
GENETestsKMT5B
Target ValidationKMT5B
Huge Navigator KMT5B [HugePedia]
snp3D : Map Gene to Disease51111
BioCentury BCIQKMT5B
ClinGenKMT5B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51111
Chemical/Pharm GKB GenePA134958369
Clinical trialKMT5B
Miscellaneous
canSAR (ICR)KMT5B (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKMT5B
EVEXKMT5B
GoPubMedKMT5B
iHOPKMT5B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:12:05 CEST 2017

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