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KMT5C (lysine methyltransferase 5C)

Identity

Alias_namesSUV420H2
suppressor of variegation 4-20 homolog 2 (Drosophila)
lysine (K)-specific methyltransferase 5C
Alias_symbol (synonym)MGC2705
Other aliasSuv4-20h2
HGNC (Hugo) KMT5C
LocusID (NCBI) 84787
Atlas_Id 43731
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 55339853 and ends at 55348121 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KMT5C (19q13.42) / MVD (16q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KMT5C   28405
Cards
Entrez_Gene (NCBI)KMT5C  84787  lysine methyltransferase 5C
AliasesSUV420H2; Suv4-20h2
GeneCards (Weizmann)KMT5C
Ensembl hg19 (Hinxton)ENSG00000133247 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133247 [Gene_View]  chr19:55339853-55348121 [Contig_View]  KMT5C [Vega]
ICGC DataPortalENSG00000133247
TCGA cBioPortalKMT5C
AceView (NCBI)KMT5C
Genatlas (Paris)KMT5C
WikiGenes84787
SOURCE (Princeton)KMT5C
Genetics Home Reference (NIH)KMT5C
Genomic and cartography
GoldenPath hg38 (UCSC)KMT5C  -     chr19:55339853-55348121 +  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KMT5C  -     19q13.42   [Description]    (hg19-Feb_2009)
EnsemblKMT5C - 19q13.42 [CytoView hg19]  KMT5C - 19q13.42 [CytoView hg38]
Mapping of homologs : NCBIKMT5C [Mapview hg19]  KMT5C [Mapview hg38]
OMIM613198   
Gene and transcription
Genbank (Entrez)AF289582 AK304562 AK308586 AW248704 BC005842
RefSeq transcript (Entrez)NM_032701
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KMT5C
Cluster EST : UnigeneHs.590982 [ NCBI ]
CGAP (NCI)Hs.590982
Alternative Splicing GalleryENSG00000133247
Gene ExpressionKMT5C [ NCBI-GEO ]   KMT5C [ EBI - ARRAY_EXPRESS ]   KMT5C [ SEEK ]   KMT5C [ MEM ]
Gene Expression Viewer (FireBrowse)KMT5C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84787
GTEX Portal (Tissue expression)KMT5C
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86Y97   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86Y97  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86Y97
Splice isoforms : SwissVarQ86Y97
Catalytic activity : Enzyme2.1.1.43 [ Enzyme-Expasy ]   2.1.1.432.1.1.43 [ IntEnz-EBI ]   2.1.1.43 [ BRENDA ]   2.1.1.43 [ KEGG ]   
PhosPhoSitePlusQ86Y97
Domaine pattern : Prosite (Expaxy)SAM_MT43_SUVAR420_2 (PS51570)    SET (PS50280)   
Domains : Interpro (EBI)Hist-Lys_N-MTase_Suvar4-20    SET_dom   
Domain families : Pfam (Sanger)SET (PF00856)   
Domain families : Pfam (NCBI)pfam00856   
Domain families : Smart (EMBL)SET (SM00317)  
Conserved Domain (NCBI)KMT5C
DMDM Disease mutations84787
Blocks (Seattle)KMT5C
PDB (SRS)3RQ4   
PDB (PDBSum)3RQ4   
PDB (IMB)3RQ4   
PDB (RSDB)3RQ4   
Structural Biology KnowledgeBase3RQ4   
SCOP (Structural Classification of Proteins)3RQ4   
CATH (Classification of proteins structures)3RQ4   
SuperfamilyQ86Y97
Human Protein AtlasENSG00000133247
Peptide AtlasQ86Y97
HPRD15454
IPIIPI00013441   IPI00479728   IPI00641165   IPI00922882   IPI00880173   IPI00878059   
Protein Interaction databases
DIP (DOE-UCLA)Q86Y97
IntAct (EBI)Q86Y97
FunCoupENSG00000133247
BioGRIDKMT5C
STRING (EMBL)KMT5C
ZODIACKMT5C
Ontologies - Pathways
QuickGOQ86Y97
Ontology : AmiGOcondensed nuclear chromosome, centromeric region  protein binding  nucleoplasm  nucleoplasm  nuclear heterochromatin  pericentric heterochromatin  transcription, DNA-templated  regulation of transcription, DNA-templated  histone-lysine N-methyltransferase activity  histone H4-K20 trimethylation  histone methyltransferase activity (H4-K20 specific)  
Ontology : EGO-EBIcondensed nuclear chromosome, centromeric region  protein binding  nucleoplasm  nucleoplasm  nuclear heterochromatin  pericentric heterochromatin  transcription, DNA-templated  regulation of transcription, DNA-templated  histone-lysine N-methyltransferase activity  histone H4-K20 trimethylation  histone methyltransferase activity (H4-K20 specific)  
NDEx NetworkKMT5C
Atlas of Cancer Signalling NetworkKMT5C
Wikipedia pathwaysKMT5C
Orthology - Evolution
OrthoDB84787
GeneTree (enSembl)ENSG00000133247
Phylogenetic Trees/Animal Genes : TreeFamKMT5C
HOVERGENQ86Y97
HOGENOMQ86Y97
Homologs : HomoloGeneKMT5C
Homology/Alignments : Family Browser (UCSC)KMT5C
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKMT5C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KMT5C
dbVarKMT5C
ClinVarKMT5C
1000_GenomesKMT5C 
Exome Variant ServerKMT5C
ExAC (Exome Aggregation Consortium)KMT5C (select the gene name)
Genetic variants : HAPMAP84787
Genomic Variants (DGV)KMT5C [DGVbeta]
DECIPHERKMT5C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKMT5C 
Mutations
ICGC Data PortalKMT5C 
TCGA Data PortalKMT5C 
Broad Tumor PortalKMT5C
OASIS PortalKMT5C [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDKMT5C
BioMutasearch KMT5C
DgiDB (Drug Gene Interaction Database)KMT5C
DoCM (Curated mutations)KMT5C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KMT5C (select a term)
intoGenKMT5C
Cancer3DKMT5C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613198   
Orphanet
MedgenKMT5C
Genetic Testing Registry KMT5C
NextProtQ86Y97 [Medical]
TSGene84787
GENETestsKMT5C
Huge Navigator KMT5C [HugePedia]
snp3D : Map Gene to Disease84787
BioCentury BCIQKMT5C
ClinGenKMT5C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84787
Chemical/Pharm GKB GenePA134934307
Clinical trialKMT5C
Miscellaneous
canSAR (ICR)KMT5C (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKMT5C
EVEXKMT5C
GoPubMedKMT5C
iHOPKMT5C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:21:53 CEST 2017

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