KMT5C (lysine methyltransferase 5C)

2015-11-01  

Identity

HGNC
KMT5C
LOCATION
19q13.42
LOCUSID
84787
ALIAS
SUV420H2,Suv4-20h2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84787
MIM: 613198
HGNC: 28405
Ensembl: ENSG00000133247

Variants:

dbSNP: 84787
ClinVar: 84787
TCGA: ENSG00000133247
COSMIC: KMT5C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133247ENST00000255613Q86Y97
ENSG00000133247ENST00000445196Q86Y97
ENSG00000133247ENST00000592631Q86Y97
ENSG00000133247ENST00000630497A0A0D9SF94

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
182964402008Preferential dimethylation of histone H4 lysine 20 by Suv4-20.55
163226862006Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins.43
213210832011SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation.38
176729182007Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.17
269049562016lncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress.17
243968692013Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2.13
212069042010Comparative analyses of SUV420H1 isoforms and SUV420H2 reveal differences in their cellular localization and effects on myogenic differentiation.12
258143622015SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3.10
287789562017Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication.10
278622262017Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation.6

Citation

Dessen P

KMT5C (lysine methyltransferase 5C)

Atlas Genet Cytogenet Oncol Haematol. 2015-11-01

Online version: http://atlasgeneticsoncology.org/gene/43731/kmt5c