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KNDC1 (kinase non-catalytic C-lobe domain (KIND) containing 1)

Identity

Alias_namesRASGEF2
C10orf23
RasGEF domain family, member 2
kinase non-catalytic C-lobe domain (KIND) containing 1
Alias_symbol (synonym)KIAA1768
bB439H18.3
FLJ25027
Other alias
HGNC (Hugo) KNDC1
LocusID (NCBI) 85442
Atlas_Id 43334
Location 10q26.3  [Link to chromosome band 10q26]
Location_base_pair Starts at 134973971 and ends at 135039916 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CCND2 (12p13.32) / KNDC1 (10q26.3)KNDC1 (10q26.3) / HMGXB3 (5q32)KNDC1 (10q26.3) / JUP (17q21.2)
KNDC1 (10q26.3) / KNDC1 (10q26.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KNDC1   29374
Cards
Entrez_Gene (NCBI)KNDC1  85442  kinase non-catalytic C-lobe domain (KIND) containing 1
AliasesC10orf23; RASGEF2; bB439H18.3
GeneCards (Weizmann)KNDC1
Ensembl hg19 (Hinxton)ENSG00000171798 [Gene_View]  chr10:134973971-135039916 [Contig_View]  KNDC1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000171798 [Gene_View]  chr10:134973971-135039916 [Contig_View]  KNDC1 [Vega]
ICGC DataPortalENSG00000171798
TCGA cBioPortalKNDC1
AceView (NCBI)KNDC1
Genatlas (Paris)KNDC1
WikiGenes85442
SOURCE (Princeton)KNDC1
Genetics Home Reference (NIH)KNDC1
Genomic and cartography
GoldenPath hg19 (UCSC)KNDC1  -     chr10:134973971-135039916 +  10q26.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KNDC1  -     10q26.3   [Description]    (hg38-Dec_2013)
EnsemblKNDC1 - 10q26.3 [CytoView hg19]  KNDC1 - 10q26.3 [CytoView hg38]
Mapping of homologs : NCBIKNDC1 [Mapview hg19]  KNDC1 [Mapview hg38]
OMIM616237   
Gene and transcription
Genbank (Entrez)AB000781 AB051555 AI146357 AI951527 AK057756
RefSeq transcript (Entrez)NM_152643
RefSeq genomic (Entrez)NC_000010 NC_018921 NT_030059 NW_004929377
Consensus coding sequences : CCDS (NCBI)KNDC1
Cluster EST : UnigeneHs.530685 [ NCBI ]
CGAP (NCI)Hs.530685
Alternative Splicing GalleryENSG00000171798
Gene ExpressionKNDC1 [ NCBI-GEO ]   KNDC1 [ EBI - ARRAY_EXPRESS ]   KNDC1 [ SEEK ]   KNDC1 [ MEM ]
Gene Expression Viewer (FireBrowse)KNDC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85442
GTEX Portal (Tissue expression)KNDC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ76NI1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ76NI1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ76NI1
Splice isoforms : SwissVarQ76NI1
PhosPhoSitePlusQ76NI1
Domaine pattern : Prosite (Expaxy)KIND (PS51377)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)   
Domains : Interpro (EBI)Kinase-like_dom    KIND_dom    KNDC1    Ras-like_Gua-exchang_fac_N    Ras_GEF_dom    RASGEF_cat_dom   
Domain families : Pfam (Sanger)KIND (PF16474)    RasGEF (PF00617)    RasGEF_N (PF00618)   
Domain families : Pfam (NCBI)pfam16474    pfam00617    pfam00618   
Domain families : Smart (EMBL)KIND (SM00750)  RasGEFN (SM00229)  
Conserved Domain (NCBI)KNDC1
DMDM Disease mutations85442
Blocks (Seattle)KNDC1
SuperfamilyQ76NI1
Human Protein AtlasENSG00000171798
Peptide AtlasQ76NI1
HPRD13931
IPIIPI00065323   IPI00872423   IPI00869295   IPI00383048   IPI00784523   IPI00869178   IPI00028193   IPI00386182   
Protein Interaction databases
DIP (DOE-UCLA)Q76NI1
IntAct (EBI)Q76NI1
FunCoupENSG00000171798
BioGRIDKNDC1
STRING (EMBL)KNDC1
ZODIACKNDC1
Ontologies - Pathways
QuickGOQ76NI1
Ontology : AmiGOpositive regulation of protein phosphorylation  molecular_function  Ras guanyl-nucleotide exchange factor activity  cellular_component  small GTPase mediated signal transduction  biological_process  cerebellar granule cell differentiation  dendrite  guanyl-nucleotide exchange factor complex  neuronal cell body  positive regulation of GTPase activity  regulation of dendrite morphogenesis  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  molecular_function  Ras guanyl-nucleotide exchange factor activity  cellular_component  small GTPase mediated signal transduction  biological_process  cerebellar granule cell differentiation  dendrite  guanyl-nucleotide exchange factor complex  neuronal cell body  positive regulation of GTPase activity  regulation of dendrite morphogenesis  
NDEx NetworkKNDC1
Atlas of Cancer Signalling NetworkKNDC1
Wikipedia pathwaysKNDC1
Orthology - Evolution
OrthoDB85442
GeneTree (enSembl)ENSG00000171798
Phylogenetic Trees/Animal Genes : TreeFamKNDC1
HOVERGENQ76NI1
HOGENOMQ76NI1
Homologs : HomoloGeneKNDC1
Homology/Alignments : Family Browser (UCSC)KNDC1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKNDC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KNDC1
dbVarKNDC1
ClinVarKNDC1
1000_GenomesKNDC1 
Exome Variant ServerKNDC1
ExAC (Exome Aggregation Consortium)KNDC1 (select the gene name)
Genetic variants : HAPMAP85442
Genomic Variants (DGV)KNDC1 [DGVbeta]
DECIPHER (Syndromes)10:134973971-135039916  ENSG00000171798
CONAN: Copy Number AnalysisKNDC1 
Mutations
ICGC Data PortalKNDC1 
TCGA Data PortalKNDC1 
Broad Tumor PortalKNDC1
OASIS PortalKNDC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKNDC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKNDC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KNDC1
DgiDB (Drug Gene Interaction Database)KNDC1
DoCM (Curated mutations)KNDC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KNDC1 (select a term)
intoGenKNDC1
Cancer3DKNDC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616237   
Orphanet
MedgenKNDC1
Genetic Testing Registry KNDC1
NextProtQ76NI1 [Medical]
TSGene85442
GENETestsKNDC1
Huge Navigator KNDC1 [HugePedia]
snp3D : Map Gene to Disease85442
BioCentury BCIQKNDC1
ClinGenKNDC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85442
Chemical/Pharm GKB GenePA134983621
Clinical trialKNDC1
Miscellaneous
canSAR (ICR)KNDC1 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKNDC1
EVEXKNDC1
GoPubMedKNDC1
iHOPKNDC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:12:12 CET 2017

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