Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

KNG1 (kininogen 1)

Identity

Alias_namesKNG
BDK
kininogen
Alias_symbol (synonym)BK
Other alias
HGNC (Hugo) KNG1
LocusID (NCBI) 3827
Atlas_Id 46049
Location 3q27.3  [Link to chromosome band 3q27]
Location_base_pair Starts at 186717309 and ends at 186744410 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KNG1 (3q27.3) / ALB (4q13.3)ST6GAL1 (3q27.3) / KNG1 (3q27.3)WDR74 (11q12.3) / KNG1 (3q27.3)
ST6GAL1 3q27.3 / KNG1 3q27.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KNG1   6383
Cards
Entrez_Gene (NCBI)KNG1  3827  kininogen 1
AliasesBDK; BK; KNG
GeneCards (Weizmann)KNG1
Ensembl hg19 (Hinxton)ENSG00000113889 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113889 [Gene_View]  chr3:186717309-186744410 [Contig_View]  KNG1 [Vega]
ICGC DataPortalENSG00000113889
TCGA cBioPortalKNG1
AceView (NCBI)KNG1
Genatlas (Paris)KNG1
WikiGenes3827
SOURCE (Princeton)KNG1
Genetics Home Reference (NIH)KNG1
Genomic and cartography
GoldenPath hg38 (UCSC)KNG1  -     chr3:186717309-186744410 +  3q27.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KNG1  -     3q27.3   [Description]    (hg19-Feb_2009)
EnsemblKNG1 - 3q27.3 [CytoView hg19]  KNG1 - 3q27.3 [CytoView hg38]
Mapping of homologs : NCBIKNG1 [Mapview hg19]  KNG1 [Mapview hg38]
OMIM228960   612358   
Gene and transcription
Genbank (Entrez)AI133186 AK223589 AK290839 AK298440 AK303768
RefSeq transcript (Entrez)NM_000893 NM_001102416 NM_001166451
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KNG1
Cluster EST : UnigeneHs.77741 [ NCBI ]
CGAP (NCI)Hs.77741
Alternative Splicing GalleryENSG00000113889
Gene ExpressionKNG1 [ NCBI-GEO ]   KNG1 [ EBI - ARRAY_EXPRESS ]   KNG1 [ SEEK ]   KNG1 [ MEM ]
Gene Expression Viewer (FireBrowse)KNG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3827
GTEX Portal (Tissue expression)KNG1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01042   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01042  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01042
Splice isoforms : SwissVarP01042
PhosPhoSitePlusP01042
Domaine pattern : Prosite (Expaxy)CYSTATIN (PS00287)    CYSTATIN_KININOGEN (PS51647)   
Domains : Interpro (EBI)Cystatin_dom    Kininogen    Kininogen-type_cystatin_dom    Prot_inh_cystat_CS   
Domain families : Pfam (Sanger)Cystatin (PF00031)   
Domain families : Pfam (NCBI)pfam00031   
Domain families : Smart (EMBL)CY (SM00043)  
Conserved Domain (NCBI)KNG1
DMDM Disease mutations3827
Blocks (Seattle)KNG1
PDB (SRS)1NY2    2WOK    4ASQ    4ASR    4ECB    4ECC    5I25   
PDB (PDBSum)1NY2    2WOK    4ASQ    4ASR    4ECB    4ECC    5I25   
PDB (IMB)1NY2    2WOK    4ASQ    4ASR    4ECB    4ECC    5I25   
PDB (RSDB)1NY2    2WOK    4ASQ    4ASR    4ECB    4ECC    5I25   
Structural Biology KnowledgeBase1NY2    2WOK    4ASQ    4ASR    4ECB    4ECC    5I25   
SCOP (Structural Classification of Proteins)1NY2    2WOK    4ASQ    4ASR    4ECB    4ECC    5I25   
CATH (Classification of proteins structures)1NY2    2WOK    4ASQ    4ASR    4ECB    4ECC    5I25   
SuperfamilyP01042
Human Protein AtlasENSG00000113889
Peptide AtlasP01042
HPRD01970
IPIIPI00032328   IPI00215894   IPI01012492   IPI00789376   IPI00924859   
Protein Interaction databases
DIP (DOE-UCLA)P01042
IntAct (EBI)P01042
FunCoupENSG00000113889
BioGRIDKNG1
STRING (EMBL)KNG1
ZODIACKNG1
Ontologies - Pathways
QuickGOP01042
Ontology : AmiGOplatelet degranulation  cysteine-type endopeptidase inhibitor activity  receptor binding  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  inflammatory response  negative regulation of cell adhesion  positive regulation of cytosolic calcium ion concentration  blood coagulation, intrinsic pathway  heparin binding  zinc ion binding  negative regulation of endopeptidase activity  negative regulation of blood coagulation  platelet alpha granule lumen  vasodilation  positive regulation of apoptotic process  negative regulation of proteolysis  extracellular exosome  blood microparticle  
Ontology : EGO-EBIplatelet degranulation  cysteine-type endopeptidase inhibitor activity  receptor binding  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  inflammatory response  negative regulation of cell adhesion  positive regulation of cytosolic calcium ion concentration  blood coagulation, intrinsic pathway  heparin binding  zinc ion binding  negative regulation of endopeptidase activity  negative regulation of blood coagulation  platelet alpha granule lumen  vasodilation  positive regulation of apoptotic process  negative regulation of proteolysis  extracellular exosome  blood microparticle  
Pathways : BIOCARTABioactive Peptide Induced Signaling Pathway [Genes]    Cells and Molecules involved in local acute inflammatory response [Genes]    Actions of Nitric Oxide in the Heart [Genes]    Intrinsic Prothrombin Activation Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkKNG1
Atlas of Cancer Signalling NetworkKNG1
Wikipedia pathwaysKNG1
Orthology - Evolution
OrthoDB3827
GeneTree (enSembl)ENSG00000113889
Phylogenetic Trees/Animal Genes : TreeFamKNG1
HOVERGENP01042
HOGENOMP01042
Homologs : HomoloGeneKNG1
Homology/Alignments : Family Browser (UCSC)KNG1
Gene fusions - Rearrangements
Fusion : MitelmanST6GAL1/KNG1 [3q27.3/3q27.3]  [t(3;3)(q27;q27)]  
Fusion: TCGAST6GAL1 3q27.3 KNG1 3q27.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKNG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KNG1
dbVarKNG1
ClinVarKNG1
1000_GenomesKNG1 
Exome Variant ServerKNG1
ExAC (Exome Aggregation Consortium)KNG1 (select the gene name)
Genetic variants : HAPMAP3827
Genomic Variants (DGV)KNG1 [DGVbeta]
DECIPHERKNG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKNG1 
Mutations
ICGC Data PortalKNG1 
TCGA Data PortalKNG1 
Broad Tumor PortalKNG1
OASIS PortalKNG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKNG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKNG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KNG1
DgiDB (Drug Gene Interaction Database)KNG1
DoCM (Curated mutations)KNG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KNG1 (select a term)
intoGenKNG1
Cancer3DKNG1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM228960    612358   
Orphanet8693   
MedgenKNG1
Genetic Testing Registry KNG1
NextProtP01042 [Medical]
TSGene3827
GENETestsKNG1
Target ValidationKNG1
Huge Navigator KNG1 [HugePedia]
snp3D : Map Gene to Disease3827
BioCentury BCIQKNG1
ClinGenKNG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3827
Chemical/Pharm GKB GenePA225
Clinical trialKNG1
Miscellaneous
canSAR (ICR)KNG1 (select the gene name)
Probes
Litterature
PubMed158 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKNG1
EVEXKNG1
GoPubMedKNG1
iHOPKNG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:39:55 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.