KNG1 (kininogen 1)

2007-02-01  

Identity

HGNC
LOCATION
3q27.3
LOCUSID
ALIAS
BDK,BK,HMWK,KNG
FUSION GENES

Other Information

Locus ID:

NCBI: 3827
MIM: 612358
HGNC: 6383
Ensembl: ENSG00000113889

Variants:

dbSNP: 3827
ClinVar: 3827
TCGA: ENSG00000113889
COSMIC: KNG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113889ENST00000287611P01042
ENSG00000113889ENST00000447445P01042
ENSG00000113889ENST00000644859P01042

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Intrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140837
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA452637hormonal contraceptives for systemic useChemicalClinicalAnnotationassociatedPD28750087

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
208766112010Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ.52
208766112010Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ.52
214510242011Bradykinin promotes the chemotactic invasion of primary brain tumors.48
191266852009Regulatory effects of ferritin on angiogenesis.47
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
203030642010Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.33
203030642010Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.33
160913692005Domain 5 of high molecular weight kininogen is antibacterial.30

Citation

Dessen P

KNG1 (kininogen 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46049/kng1