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KNSTRN (kinetochore localized astrin (SPAG5) binding protein)

Identity

Alias (NCBI)C15orf23
HSD11
ROCHIS
SKAP
TRAF4AF1
HGNC (Hugo) KNSTRN
HGNC Alias symbFLJ14502
SKAP
kinastrin
TRAF4AF1
HGNC Alias namesmall kinetochore-associated protein
 kinetochore-localized astrin-binding protein
 TRAF4 associated factor 1
HGNC Previous nameC15orf23
HGNC Previous namechromosome 15 open reading frame 23
 kinetochore localized astrin/SPAG5 binding protein
LocusID (NCBI) 90417
Atlas_Id 55018
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 40382721 and ends at 40394288 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IVD (15q15.1) / KNSTRN (15q15.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KNSTRN   30767
Cards
Entrez_Gene (NCBI)KNSTRN    kinetochore localized astrin (SPAG5) binding protein
AliasesC15orf23; HSD11; ROCHIS; SKAP; 
TRAF4AF1
GeneCards (Weizmann)KNSTRN
Ensembl hg19 (Hinxton)ENSG00000128944 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128944 [Gene_View]  ENSG00000128944 [Sequence]  chr15:40382721-40394288 [Contig_View]  KNSTRN [Vega]
ICGC DataPortalENSG00000128944
TCGA cBioPortalKNSTRN
AceView (NCBI)KNSTRN
Genatlas (Paris)KNSTRN
SOURCE (Princeton)KNSTRN
Genetics Home Reference (NIH)KNSTRN
Genomic and cartography
GoldenPath hg38 (UCSC)KNSTRN  -     chr15:40382721-40394288 +  15q15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KNSTRN  -     15q15.1   [Description]    (hg19-Feb_2009)
GoldenPathKNSTRN - 15q15.1 [CytoView hg19]  KNSTRN - 15q15.1 [CytoView hg38]
ImmunoBaseENSG00000128944
Genome Data Viewer NCBIKNSTRN [Mapview hg19]  
OMIM613328   614718   
Gene and transcription
Genbank (Entrez)AK027408 AK125765 AK298156 AK301887 AW156972
RefSeq transcript (Entrez)NM_001142761 NM_001142762 NM_033286
Consensus coding sequences : CCDS (NCBI)KNSTRN
Gene ExpressionKNSTRN [ NCBI-GEO ]   KNSTRN [ EBI - ARRAY_EXPRESS ]   KNSTRN [ SEEK ]   KNSTRN [ MEM ]
Gene Expression Viewer (FireBrowse)KNSTRN [ Firebrowse - Broad ]
GenevisibleExpression of KNSTRN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90417
GTEX Portal (Tissue expression)KNSTRN
Human Protein AtlasENSG00000128944-KNSTRN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y448   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y448  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y448
PhosPhoSitePlusQ9Y448
Domains : Interpro (EBI)SKAP   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)KNSTRN
SuperfamilyQ9Y448
AlphaFold pdb e-kbQ9Y448   
Human Protein Atlas [tissue]ENSG00000128944-KNSTRN [tissue]
HPRD12669
Protein Interaction databases
DIP (DOE-UCLA)Q9Y448
IntAct (EBI)Q9Y448
BioGRIDKNSTRN
STRING (EMBL)KNSTRN
ZODIACKNSTRN
Ontologies - Pathways
QuickGOQ9Y448
Ontology : AmiGOmitotic sister chromatid segregation  mitotic sister chromatid segregation  microtubule cytoskeleton organization  kinetochore  kinetochore  spindle pole  ruffle  protein binding  nucleus  cytoplasm  plasma membrane  spindle organization  spindle organization  chromosome segregation  cell migration  centriolar satellite  centriolar satellite  microtubule plus-end  microtubule plus-end  protein homodimerization activity  microtubule plus-end binding  cell division  regulation of attachment of spindle microtubules to kinetochore  regulation of attachment of spindle microtubules to kinetochore  cellular response to epidermal growth factor stimulus  mitotic spindle  mitotic spindle  
Ontology : EGO-EBImitotic sister chromatid segregation  mitotic sister chromatid segregation  microtubule cytoskeleton organization  kinetochore  kinetochore  spindle pole  ruffle  protein binding  nucleus  cytoplasm  plasma membrane  spindle organization  spindle organization  chromosome segregation  cell migration  centriolar satellite  centriolar satellite  microtubule plus-end  microtubule plus-end  protein homodimerization activity  microtubule plus-end binding  cell division  regulation of attachment of spindle microtubules to kinetochore  regulation of attachment of spindle microtubules to kinetochore  cellular response to epidermal growth factor stimulus  mitotic spindle  mitotic spindle  
NDEx NetworkKNSTRN
Atlas of Cancer Signalling NetworkKNSTRN
Wikipedia pathwaysKNSTRN
Orthology - Evolution
OrthoDB90417
GeneTree (enSembl)ENSG00000128944
Phylogenetic Trees/Animal Genes : TreeFamKNSTRN
Homologs : HomoloGeneKNSTRN
Homology/Alignments : Family Browser (UCSC)KNSTRN
Gene fusions - Rearrangements
Fusion : QuiverKNSTRN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKNSTRN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KNSTRN
dbVarKNSTRN
ClinVarKNSTRN
MonarchKNSTRN
1000_GenomesKNSTRN 
Exome Variant ServerKNSTRN
GNOMAD BrowserENSG00000128944
Varsome BrowserKNSTRN
ACMGKNSTRN variants
VarityQ9Y448
Genomic Variants (DGV)KNSTRN [DGVbeta]
DECIPHERKNSTRN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKNSTRN 
Mutations
ICGC Data PortalKNSTRN 
TCGA Data PortalKNSTRN 
Broad Tumor PortalKNSTRN
OASIS PortalKNSTRN [ Somatic mutations - Copy number]
Cancer Gene: CensusKNSTRN 
Somatic Mutations in Cancer : COSMICKNSTRN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKNSTRN
Mutations and Diseases : HGMDKNSTRN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKNSTRN
DgiDB (Drug Gene Interaction Database)KNSTRN
DoCM (Curated mutations)KNSTRN
CIViC (Clinical Interpretations of Variants in Cancer)KNSTRN
Cancer3DKNSTRN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613328    614718   
Orphanet
DisGeNETKNSTRN
MedgenKNSTRN
Genetic Testing Registry KNSTRN
NextProtQ9Y448 [Medical]
GENETestsKNSTRN
Target ValidationKNSTRN
Huge Navigator KNSTRN [HugePedia]
ClinGenKNSTRN
Clinical trials, drugs, therapy
MyCancerGenomeKNSTRN
Protein Interactions : CTDKNSTRN
Pharm GKB GenePA134895025
PharosQ9Y448
Clinical trialKNSTRN
Miscellaneous
canSAR (ICR)KNSTRN
HarmonizomeKNSTRN
DataMed IndexKNSTRN
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKNSTRN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:15:19 CEST 2021

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