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KPNA1 (karyopherin subunit alpha 1)

Identity

Alias_nameskaryopherin alpha 1 (importin alpha 5)
karyopherin alpha 1
Alias_symbol (synonym)SRP1
RCH2
NPI-1
IPOA5
Other alias
HGNC (Hugo) KPNA1
LocusID (NCBI) 3836
Atlas_Id 41096
Location 3q21.1  [Link to chromosome band 3q21]
Location_base_pair Starts at 122140748 and ends at 122233786 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KPNA1 (3q21.1) / CD86 (3q13.33)KPNA1 (3q21.1) / GMPS (3q25.31)KPNA1 (3q21.1) / KPNA1 (3q21.1)
KPNA1 (3q21.1) / SMC1B (22q13.31)KPNA1 3q21.1 / CD86 3q13.33KPNA1 3q21.1 / GMPS 3q25.31
KPNA1 3q21.1 / SMC1B 22q13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KPNA1   6394
Cards
Entrez_Gene (NCBI)KPNA1  3836  karyopherin subunit alpha 1
AliasesIPOA5; NPI-1; RCH2; SRP1
GeneCards (Weizmann)KPNA1
Ensembl hg19 (Hinxton)ENSG00000114030 [Gene_View]  chr3:122140748-122233786 [Contig_View]  KPNA1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000114030 [Gene_View]  chr3:122140748-122233786 [Contig_View]  KPNA1 [Vega]
ICGC DataPortalENSG00000114030
TCGA cBioPortalKPNA1
AceView (NCBI)KPNA1
Genatlas (Paris)KPNA1
WikiGenes3836
SOURCE (Princeton)KPNA1
Genetics Home Reference (NIH)KPNA1
Genomic and cartography
GoldenPath hg19 (UCSC)KPNA1  -     chr3:122140748-122233786 -  3q21.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KPNA1  -     3q21.1   [Description]    (hg38-Dec_2013)
EnsemblKPNA1 - 3q21.1 [CytoView hg19]  KPNA1 - 3q21.1 [CytoView hg38]
Mapping of homologs : NCBIKPNA1 [Mapview hg19]  KPNA1 [Mapview hg38]
OMIM600686   
Gene and transcription
Genbank (Entrez)AA689229 AF035311 AI216375 AK125626 AK128280
RefSeq transcript (Entrez)NM_002264
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)KPNA1
Cluster EST : UnigeneHs.161008 [ NCBI ]
CGAP (NCI)Hs.161008
Alternative Splicing GalleryENSG00000114030
Gene ExpressionKPNA1 [ NCBI-GEO ]   KPNA1 [ EBI - ARRAY_EXPRESS ]   KPNA1 [ SEEK ]   KPNA1 [ MEM ]
Gene Expression Viewer (FireBrowse)KPNA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3836
GTEX Portal (Tissue expression)KPNA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52294   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52294  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52294
Splice isoforms : SwissVarP52294
PhosPhoSitePlusP52294
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Arm_3    Armadillo    Importin-a_IBB    Importing_su_alpha   
Domain families : Pfam (Sanger)Arm (PF00514)    Arm_3 (PF16186)    IBB (PF01749)   
Domain families : Pfam (NCBI)pfam00514    pfam16186    pfam01749   
Domain families : Smart (EMBL)ARM (SM00185)  
Conserved Domain (NCBI)KPNA1
DMDM Disease mutations3836
Blocks (Seattle)KPNA1
PDB (SRS)2JDQ    3TJ3    4B18   
PDB (PDBSum)2JDQ    3TJ3    4B18   
PDB (IMB)2JDQ    3TJ3    4B18   
PDB (RSDB)2JDQ    3TJ3    4B18   
Structural Biology KnowledgeBase2JDQ    3TJ3    4B18   
SCOP (Structural Classification of Proteins)2JDQ    3TJ3    4B18   
CATH (Classification of proteins structures)2JDQ    3TJ3    4B18   
SuperfamilyP52294
Human Protein AtlasENSG00000114030
Peptide AtlasP52294
HPRD02819
IPIIPI00303292   IPI00790454   IPI00945733   IPI00977019   IPI00796516   IPI00982649   
Protein Interaction databases
DIP (DOE-UCLA)P52294
IntAct (EBI)P52294
FunCoupENSG00000114030
BioGRIDKPNA1
STRING (EMBL)KPNA1
ZODIACKPNA1
Ontologies - Pathways
QuickGOP52294
Ontology : AmiGOregulation of DNA recombination  protein binding  nucleus  nucleus  nuclear pore  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  apoptotic DNA fragmentation  NLS-bearing protein import into nucleus  nuclear localization sequence binding  protein transporter activity  modulation by virus of host process  dendrite  positive regulation of protein import into nucleus  intracellular transport of virus  
Ontology : EGO-EBIregulation of DNA recombination  protein binding  nucleus  nucleus  nuclear pore  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  apoptotic DNA fragmentation  NLS-bearing protein import into nucleus  nuclear localization sequence binding  protein transporter activity  modulation by virus of host process  dendrite  positive regulation of protein import into nucleus  intracellular transport of virus  
Pathways : KEGGInfluenza A   
NDEx NetworkKPNA1
Atlas of Cancer Signalling NetworkKPNA1
Wikipedia pathwaysKPNA1
Orthology - Evolution
OrthoDB3836
GeneTree (enSembl)ENSG00000114030
Phylogenetic Trees/Animal Genes : TreeFamKPNA1
HOVERGENP52294
HOGENOMP52294
Homologs : HomoloGeneKPNA1
Homology/Alignments : Family Browser (UCSC)KPNA1
Gene fusions - Rearrangements
Fusion : MitelmanKPNA1/CD86 [3q21.1/3q13.33]  
Fusion : MitelmanKPNA1/GMPS [3q21.1/3q25.31]  [t(3;3)(q21;q25)]  
Fusion : MitelmanKPNA1/SMC1B [3q21.1/22q13.31]  [t(3;22)(q21;q13)]  
Fusion: TCGAKPNA1 3q21.1 CD86 3q13.33 KIRC
Fusion: TCGAKPNA1 3q21.1 GMPS 3q25.31 LUAD
Fusion: TCGAKPNA1 3q21.1 SMC1B 22q13.31 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKPNA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KPNA1
dbVarKPNA1
ClinVarKPNA1
1000_GenomesKPNA1 
Exome Variant ServerKPNA1
ExAC (Exome Aggregation Consortium)KPNA1 (select the gene name)
Genetic variants : HAPMAP3836
Genomic Variants (DGV)KPNA1 [DGVbeta]
DECIPHER (Syndromes)3:122140748-122233786  ENSG00000114030
CONAN: Copy Number AnalysisKPNA1 
Mutations
ICGC Data PortalKPNA1 
TCGA Data PortalKPNA1 
Broad Tumor PortalKPNA1
OASIS PortalKPNA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKPNA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKPNA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KPNA1
DgiDB (Drug Gene Interaction Database)KPNA1
DoCM (Curated mutations)KPNA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KPNA1 (select a term)
intoGenKPNA1
Cancer3DKPNA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600686   
Orphanet
MedgenKPNA1
Genetic Testing Registry KPNA1
NextProtP52294 [Medical]
TSGene3836
GENETestsKPNA1
Huge Navigator KPNA1 [HugePedia]
snp3D : Map Gene to Disease3836
BioCentury BCIQKPNA1
ClinGenKPNA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3836
Chemical/Pharm GKB GenePA30185
Clinical trialKPNA1
Miscellaneous
canSAR (ICR)KPNA1 (select the gene name)
Probes
Litterature
PubMed165 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKPNA1
EVEXKPNA1
GoPubMedKPNA1
iHOPKPNA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:12:13 CET 2017

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