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KPNA1 (karyopherin subunit alpha 1)

Identity

Alias (NCBI)IPOA5
NPI-1
RCH2
SRP1
HGNC (Hugo) KPNA1
HGNC Alias symbSRP1
RCH2
NPI-1
IPOA5
HGNC Alias nameimportin alpha 5
HGNC Previous namekaryopherin alpha 1 (importin alpha 5)
 karyopherin alpha 1
LocusID (NCBI) 3836
Atlas_Id 41096
Location 3q21.1  [Link to chromosome band 3q21]
Location_base_pair Starts at 122421904 and ends at 122514939 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KPNA1 (3q21.1) / CD86 (3q13.33)KPNA1 (3q21.1) / GMPS (3q25.31)KPNA1 (3q21.1) / KPNA1 (3q21.1)
KPNA1 (3q21.1) / SMC1B (22q13.31)KPNA1 3q21.1 / CD86 3q13.33KPNA1 3q21.1 / GMPS 3q25.31
KPNA1 3q21.1 / SMC1B 22q13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KPNA1   6394
Cards
Entrez_Gene (NCBI)KPNA1    karyopherin subunit alpha 1
AliasesIPOA5; NPI-1; RCH2; SRP1
GeneCards (Weizmann)KPNA1
Ensembl hg19 (Hinxton)ENSG00000114030 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114030 [Gene_View]  ENSG00000114030 [Sequence]  chr3:122421904-122514939 [Contig_View]  KPNA1 [Vega]
ICGC DataPortalENSG00000114030
TCGA cBioPortalKPNA1
AceView (NCBI)KPNA1
Genatlas (Paris)KPNA1
SOURCE (Princeton)KPNA1
Genetics Home Reference (NIH)KPNA1
Genomic and cartography
GoldenPath hg38 (UCSC)KPNA1  -     chr3:122421904-122514939 -  3q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KPNA1  -     3q21.1   [Description]    (hg19-Feb_2009)
GoldenPathKPNA1 - 3q21.1 [CytoView hg19]  KPNA1 - 3q21.1 [CytoView hg38]
ImmunoBaseENSG00000114030
Genome Data Viewer NCBIKPNA1 [Mapview hg19]  
OMIM600686   
Gene and transcription
Genbank (Entrez)AA689229 AF035311 AI216375 AK125626 AK128280
RefSeq transcript (Entrez)NM_002264
Consensus coding sequences : CCDS (NCBI)KPNA1
Gene ExpressionKPNA1 [ NCBI-GEO ]   KPNA1 [ EBI - ARRAY_EXPRESS ]   KPNA1 [ SEEK ]   KPNA1 [ MEM ]
Gene Expression Viewer (FireBrowse)KPNA1 [ Firebrowse - Broad ]
GenevisibleExpression of KPNA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3836
GTEX Portal (Tissue expression)KPNA1
Human Protein AtlasENSG00000114030-KPNA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52294   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52294  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52294
PhosPhoSitePlusP52294
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Arm_3    Armadillo    Importin-a_IBB    Importin-a_IBB_sf    Importin_alpha   
Domain families : Pfam (Sanger)Arm (PF00514)    Arm_3 (PF16186)    IBB (PF01749)   
Domain families : Pfam (NCBI)pfam00514    pfam16186    pfam01749   
Domain families : Smart (EMBL)ARM (SM00185)  
Conserved Domain (NCBI)KPNA1
PDB (RSDB)2JDQ    3TJ3    4B18    6WX9   
PDB Europe2JDQ    3TJ3    4B18    6WX9   
PDB (PDBSum)2JDQ    3TJ3    4B18    6WX9   
PDB (IMB)2JDQ    3TJ3    4B18    6WX9   
Structural Biology KnowledgeBase2JDQ    3TJ3    4B18    6WX9   
SCOP (Structural Classification of Proteins)2JDQ    3TJ3    4B18    6WX9   
CATH (Classification of proteins structures)2JDQ    3TJ3    4B18    6WX9   
SuperfamilyP52294
AlphaFold pdb e-kbP52294   
Human Protein Atlas [tissue]ENSG00000114030-KPNA1 [tissue]
HPRD02819
Protein Interaction databases
DIP (DOE-UCLA)P52294
IntAct (EBI)P52294
BioGRIDKPNA1
STRING (EMBL)KPNA1
ZODIACKPNA1
Ontologies - Pathways
QuickGOP52294
Ontology : AmiGOregulation of DNA recombination  protein binding  nucleus  nucleus  nuclear pore  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  apoptotic DNA fragmentation  NLS-bearing protein import into nucleus  nuclear localization sequence binding  postsynaptic density  skeletal muscle satellite cell proliferation  satellite cell activation involved in skeletal muscle regeneration  modulation by virus of host cellular process  dendrite  regulation of apoptotic process  host cell  regulation of canonical Wnt signaling pathway  nuclear import signal receptor activity  intracellular transport of virus  glutamatergic synapse  postsynapse to nucleus signaling pathway  
Ontology : EGO-EBIregulation of DNA recombination  protein binding  nucleus  nucleus  nuclear pore  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  apoptotic DNA fragmentation  NLS-bearing protein import into nucleus  nuclear localization sequence binding  postsynaptic density  skeletal muscle satellite cell proliferation  satellite cell activation involved in skeletal muscle regeneration  modulation by virus of host cellular process  dendrite  regulation of apoptotic process  host cell  regulation of canonical Wnt signaling pathway  nuclear import signal receptor activity  intracellular transport of virus  glutamatergic synapse  postsynapse to nucleus signaling pathway  
Pathways : KEGGInfluenza A   
NDEx NetworkKPNA1
Atlas of Cancer Signalling NetworkKPNA1
Wikipedia pathwaysKPNA1
Orthology - Evolution
OrthoDB3836
GeneTree (enSembl)ENSG00000114030
Phylogenetic Trees/Animal Genes : TreeFamKPNA1
Homologs : HomoloGeneKPNA1
Homology/Alignments : Family Browser (UCSC)KPNA1
Gene fusions - Rearrangements
Fusion : MitelmanKPNA1/CD86 [3q21.1/3q13.33]  
Fusion : MitelmanKPNA1/GMPS [3q21.1/3q25.31]  
Fusion : MitelmanKPNA1/SMC1B [3q21.1/22q13.31]  
Fusion : QuiverKPNA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKPNA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KPNA1
dbVarKPNA1
ClinVarKPNA1
MonarchKPNA1
1000_GenomesKPNA1 
Exome Variant ServerKPNA1
GNOMAD BrowserENSG00000114030
Varsome BrowserKPNA1
ACMGKPNA1 variants
VarityP52294
Genomic Variants (DGV)KPNA1 [DGVbeta]
DECIPHERKPNA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKPNA1 
Mutations
ICGC Data PortalKPNA1 
TCGA Data PortalKPNA1 
Broad Tumor PortalKPNA1
OASIS PortalKPNA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKPNA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKPNA1
Mutations and Diseases : HGMDKPNA1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKPNA1
DgiDB (Drug Gene Interaction Database)KPNA1
DoCM (Curated mutations)KPNA1
CIViC (Clinical Interpretations of Variants in Cancer)KPNA1
Cancer3DKPNA1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600686   
Orphanet
DisGeNETKPNA1
MedgenKPNA1
Genetic Testing Registry KPNA1
NextProtP52294 [Medical]
GENETestsKPNA1
Target ValidationKPNA1
Huge Navigator KPNA1 [HugePedia]
ClinGenKPNA1
Clinical trials, drugs, therapy
MyCancerGenomeKPNA1
Protein Interactions : CTDKPNA1
Pharm GKB GenePA30185
PharosP52294
Clinical trialKPNA1
Miscellaneous
canSAR (ICR)KPNA1
HarmonizomeKPNA1
DataMed IndexKPNA1
Probes
Litterature
PubMed235 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKPNA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:15:19 CEST 2021

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