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KPNA3 (karyopherin subunit alpha 3)

Identity

Alias_nameskaryopherin alpha 3 (importin alpha 4)
karyopherin alpha 3
Alias_symbol (synonym)SRP1gamma
SRP4
hSRP1
IPOA4
Other aliasSRP1
HGNC (Hugo) KPNA3
LocusID (NCBI) 3839
Atlas_Id 41098
Location 13q14.2  [Link to chromosome band 13q14]
Location_base_pair Starts at 49699307 and ends at 49792921 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EBPL (13q14.2) / KPNA3 (13q14.2)KPNA3 (13q14.2) / FGF2 (4q27)KPNA3 (13q14.2) / RP11-47I22.3 ()
KPNA3 (13q14.2) / RP11-47I22.4 ()KPNA3 (13q14.2) / SND1 (7q32.1)LAMB1 (7q31.1) / KPNA3 (13q14.2)
SMG1 (16p12.3) / KPNA3 (13q14.2)KPNA3 13q14.2 / FGF2 4q27KPNA3 13q14.2 RP11-47I22.3
KPNA3 13q14.2 RP11-47I22.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KPNA3   6396
Cards
Entrez_Gene (NCBI)KPNA3  3839  karyopherin subunit alpha 3
AliasesIPOA4; SRP1; SRP1gamma; SRP4; 
hSRP1
GeneCards (Weizmann)KPNA3
Ensembl hg19 (Hinxton)ENSG00000102753 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102753 [Gene_View]  chr13:49699307-49792921 [Contig_View]  KPNA3 [Vega]
ICGC DataPortalENSG00000102753
TCGA cBioPortalKPNA3
AceView (NCBI)KPNA3
Genatlas (Paris)KPNA3
WikiGenes3839
SOURCE (Princeton)KPNA3
Genetics Home Reference (NIH)KPNA3
Genomic and cartography
GoldenPath hg38 (UCSC)KPNA3  -     chr13:49699307-49792921 -  13q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KPNA3  -     13q14.2   [Description]    (hg19-Feb_2009)
EnsemblKPNA3 - 13q14.2 [CytoView hg19]  KPNA3 - 13q14.2 [CytoView hg38]
Mapping of homologs : NCBIKPNA3 [Mapview hg19]  KPNA3 [Mapview hg38]
OMIM601892   
Gene and transcription
Genbank (Entrez)AF005263 AF034756 AI309735 AK223480 AK290528
RefSeq transcript (Entrez)NM_002267
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KPNA3
Cluster EST : UnigeneHs.527919 [ NCBI ]
CGAP (NCI)Hs.527919
Alternative Splicing GalleryENSG00000102753
Gene ExpressionKPNA3 [ NCBI-GEO ]   KPNA3 [ EBI - ARRAY_EXPRESS ]   KPNA3 [ SEEK ]   KPNA3 [ MEM ]
Gene Expression Viewer (FireBrowse)KPNA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3839
GTEX Portal (Tissue expression)KPNA3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00505   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00505  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00505
Splice isoforms : SwissVarO00505
PhosPhoSitePlusO00505
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Arm_3    Armadillo    Importin-a_IBB    Importing_su_alpha   
Domain families : Pfam (Sanger)Arm (PF00514)    Arm_3 (PF16186)    IBB (PF01749)   
Domain families : Pfam (NCBI)pfam00514    pfam16186    pfam01749   
Domain families : Smart (EMBL)ARM (SM00185)  
Conserved Domain (NCBI)KPNA3
DMDM Disease mutations3839
Blocks (Seattle)KPNA3
SuperfamilyO00505
Human Protein AtlasENSG00000102753
Peptide AtlasO00505
HPRD03536
IPIIPI00299033   IPI00643131   
Protein Interaction databases
DIP (DOE-UCLA)O00505
IntAct (EBI)O00505
FunCoupENSG00000102753
BioGRIDKPNA3
STRING (EMBL)KPNA3
ZODIACKPNA3
Ontologies - Pathways
QuickGOO00505
Ontology : AmiGOprotein binding  nuclear pore  nucleoplasm  nucleoplasm  cytosol  cytosol  protein complex assembly  NLS-bearing protein import into nucleus  protein C-terminus binding  nuclear localization sequence binding  protein transporter activity  modulation by virus of host process  viral entry into host cell  viral penetration into host nucleus  intracellular transport of virus  
Ontology : EGO-EBIprotein binding  nuclear pore  nucleoplasm  nucleoplasm  cytosol  cytosol  protein complex assembly  NLS-bearing protein import into nucleus  protein C-terminus binding  nuclear localization sequence binding  protein transporter activity  modulation by virus of host process  viral entry into host cell  viral penetration into host nucleus  intracellular transport of virus  
NDEx NetworkKPNA3
Atlas of Cancer Signalling NetworkKPNA3
Wikipedia pathwaysKPNA3
Orthology - Evolution
OrthoDB3839
GeneTree (enSembl)ENSG00000102753
Phylogenetic Trees/Animal Genes : TreeFamKPNA3
HOVERGENO00505
HOGENOMO00505
Homologs : HomoloGeneKPNA3
Homology/Alignments : Family Browser (UCSC)KPNA3
Gene fusions - Rearrangements
Fusion : MitelmanKPNA3/FGF2 [13q14.2/4q27]  
Fusion: TCGAKPNA3 13q14.2 FGF2 4q27 BLCA
Fusion: TCGAKPNA3 13q14.2 RP11-47I22.3 BRCA
Fusion: TCGAKPNA3 13q14.2 RP11-47I22.4 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKPNA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KPNA3
dbVarKPNA3
ClinVarKPNA3
1000_GenomesKPNA3 
Exome Variant ServerKPNA3
ExAC (Exome Aggregation Consortium)KPNA3 (select the gene name)
Genetic variants : HAPMAP3839
Genomic Variants (DGV)KPNA3 [DGVbeta]
DECIPHERKPNA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKPNA3 
Mutations
ICGC Data PortalKPNA3 
TCGA Data PortalKPNA3 
Broad Tumor PortalKPNA3
OASIS PortalKPNA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKPNA3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKPNA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KPNA3
DgiDB (Drug Gene Interaction Database)KPNA3
DoCM (Curated mutations)KPNA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KPNA3 (select a term)
intoGenKPNA3
Cancer3DKPNA3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601892   
Orphanet
MedgenKPNA3
Genetic Testing Registry KPNA3
NextProtO00505 [Medical]
TSGene3839
GENETestsKPNA3
Target ValidationKPNA3
Huge Navigator KPNA3 [HugePedia]
snp3D : Map Gene to Disease3839
BioCentury BCIQKPNA3
ClinGenKPNA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3839
Chemical/Pharm GKB GenePA30187
Clinical trialKPNA3
Miscellaneous
canSAR (ICR)KPNA3 (select the gene name)
Probes
Litterature
PubMed101 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKPNA3
EVEXKPNA3
GoPubMedKPNA3
iHOPKPNA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:14:49 CEST 2017

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