Identity
HGNC
LOCATION
13q14.2
LOCUSID
ALIAS
IPOA4,SRP1,SRP1gamma,SRP4,hSRP1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3839
MIM: 601892
HGNC: 6396
Ensembl: ENSG00000102753
Variants:
dbSNP: 3839
ClinVar: 3839
TCGA: ENSG00000102753
COSMIC: KPNA3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000102753 | ENST00000261667 | O00505 |
| ENSG00000102753 | ENST00000261667 | A0A024RDV7 |
| ENSG00000102753 | ENST00000436760 | H0Y4S9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36593106 | 2023 | KPNA3 promotes epithelial-mesenchymal transition by regulating TGF-β and AKT signaling pathways in MDA-MB-231, a triple-negative breast cancer cell line. | 0 |
| 37575080 | 2023 | SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis. | 1 |
| 36593106 | 2023 | KPNA3 promotes epithelial-mesenchymal transition by regulating TGF-β and AKT signaling pathways in MDA-MB-231, a triple-negative breast cancer cell line. | 0 |
| 37575080 | 2023 | SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis. | 1 |
| 34564892 | 2021 | Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia. | 2 |
| 34564892 | 2021 | Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia. | 2 |
| 29476013 | 2018 | Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3. | 22 |
| 30098595 | 2018 | LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3. | 74 |
| 29476013 | 2018 | Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3. | 22 |
| 30098595 | 2018 | LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3. | 74 |
| 28179530 | 2017 | Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB. | 59 |
| 28179530 | 2017 | Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB. | 59 |
| 26245896 | 2015 | Karyopherin α 3 and karyopherin α 4 proteins mediate the nuclear import of methyl-CpG binding protein 2. | 15 |
| 26245896 | 2015 | Karyopherin α 3 and karyopherin α 4 proteins mediate the nuclear import of methyl-CpG binding protein 2. | 15 |
| 22960338 | 2012 | KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. | 11 |
Citation
Dessen P
KPNA3 (karyopherin subunit alpha 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41098/kpna3
