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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

Donate (in Euros)

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KPNA4 (karyopherin alpha 4 (importin alpha 3))

Identity

Other namesIPOA3
QIP1
SRP3
HGNC (Hugo) KPNA4
LocusID (NCBI) 3840
Location 3q25.33
Location_base_pair Starts at 160212783 and ends at 160283376 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)KPNA4   6397
Cards
Entrez_Gene (NCBI)KPNA4  3840  karyopherin alpha 4 (importin alpha 3)
GeneCards (Weizmann)KPNA4
Ensembl hg19 (Hinxton)ENSG00000186432 [Gene_View]  chr3:160212783-160283376 [Contig_View]  KPNA4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000186432 [Gene_View]  chr3:160212783-160283376 [Contig_View]  KPNA4 [Vega]
ICGC DataPortalENSG00000186432
cBioPortalKPNA4
AceView (NCBI)KPNA4
Genatlas (Paris)KPNA4
WikiGenes3840
SOURCE (Princeton)KPNA4
Genomic and cartography
GoldenPath hg19 (UCSC)KPNA4  -     chr3:160212783-160283376 -  3q25.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KPNA4  -     3q25.33   [Description]    (hg38-Dec_2013)
EnsemblKPNA4 - 3q25.33 [CytoView hg19]  KPNA4 - 3q25.33 [CytoView hg38]
Mapping of homologs : NCBIKPNA4 [Mapview hg19]  KPNA4 [Mapview hg38]
OMIM602970   
Gene and transcription
Genbank (Entrez)AB002533 AF038199 AK021602 AK055675 AK129841
RefSeq transcript (Entrez)NM_002268
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NT_005612 NW_001838884 NW_004929311
Consensus coding sequences : CCDS (NCBI)KPNA4
Cluster EST : UnigeneHs.467866 [ NCBI ]
CGAP (NCI)Hs.467866
Alternative Splicing : Fast-db (Paris)GSHG0022198
Alternative Splicing GalleryENSG00000186432
Gene ExpressionKPNA4 [ NCBI-GEO ]     KPNA4 [ SEEK ]   KPNA4 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00629 (Uniprot)
NextProtO00629  [Medical]
With graphics : InterProO00629
Splice isoforms : SwissVarO00629 (Swissvar)
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Armadillo    Importin-a_IBB    Importing_su_alpha   
Related proteins : CluSTrO00629
Domain families : Pfam (Sanger)Arm (PF00514)    IBB (PF01749)   
Domain families : Pfam (NCBI)pfam00514    pfam01749   
Domain families : Smart (EMBL)ARM (SM00185)  
DMDM Disease mutations3840
Blocks (Seattle)O00629
Human Protein AtlasENSG00000186432
Peptide AtlasO00629
HPRD04275
IPIIPI00012578   IPI00386807   IPI00386960   IPI00946316   
Protein Interaction databases
DIP (DOE-UCLA)O00629
IntAct (EBI)O00629
FunCoupENSG00000186432
BioGRIDKPNA4
IntegromeDBKPNA4
STRING (EMBL)KPNA4
Ontologies - Pathways
QuickGOO00629
Ontology : AmiGOprotein binding  nucleoplasm  cytosol  NLS-bearing protein import into nucleus  protein transporter activity  cytokine-mediated signaling pathway  extracellular vesicular exosome  
Ontology : EGO-EBIprotein binding  nucleoplasm  cytosol  NLS-bearing protein import into nucleus  protein transporter activity  cytokine-mediated signaling pathway  extracellular vesicular exosome  
Protein Interaction DatabaseKPNA4
DoCM (Curated mutations)KPNA4
Wikipedia pathwaysKPNA4
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerKPNA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KPNA4
dbVarKPNA4
ClinVarKPNA4
1000_GenomesKPNA4 
Exome Variant ServerKPNA4
SNP (GeneSNP Utah)KPNA4
SNP : HGBaseKPNA4
Genetic variants : HAPMAPKPNA4
Genomic Variants (DGV)KPNA4 [DGVbeta]
Mutations
ICGC Data PortalENSG00000186432 
Somatic Mutations in Cancer : COSMICKPNA4 
CONAN: Copy Number AnalysisKPNA4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:160212783-160283376
Mutations and Diseases : HGMDKPNA4
OMIM602970   
MedgenKPNA4
NextProtO00629 [Medical]
GENETestsKPNA4
Disease Genetic AssociationKPNA4
Huge Navigator KPNA4 [HugePedia]  KPNA4 [HugeCancerGEM]
snp3D : Map Gene to Disease3840
DGIdb (Drug Gene Interaction db)KPNA4
General knowledge
Homologs : HomoloGeneKPNA4
Homology/Alignments : Family Browser (UCSC)KPNA4
Phylogenetic Trees/Animal Genes : TreeFamKPNA4
Chemical/Protein Interactions : CTD3840
Chemical/Pharm GKB GenePA30188
Clinical trialKPNA4
Cancer Resource (Charite)ENSG00000186432
Other databases
Probes
Litterature
PubMed94 Pubmed reference(s) in Entrez
CoreMineKPNA4
GoPubMedKPNA4
iHOPKPNA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 14 16:29:29 CET 2015

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