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KPNA4 (karyopherin subunit alpha 4)

Identity

Alias_nameskaryopherin alpha 4 (importin alpha 3)
karyopherin alpha 4
Alias_symbol (synonym)QIP1
SRP3
IPOA3
MGC12217
MGC26703
Other alias
HGNC (Hugo) KPNA4
LocusID (NCBI) 3840
Atlas_Id 41099
Location 13q14.2  [Link to chromosome band 13q14]
Location_base_pair Starts at 160494995 and ends at 160565588 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EPHA5 (4q13.1) / KPNA4 (3q25.33)FTL (19q13.33) / KPNA4 (3q25.33)KPNA4 (3q25.33) / ANO10 (3p22.1)
KPNA4 (3q25.33) / LIG1 (19q13.33)KPNA4 (3q25.33) / PALM2 (9q31.3)KPNA4 (3q25.33) / PLXNC1 (12q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;9)(q25;q31) KPNA4/PALM2


External links

Nomenclature
HGNC (Hugo)KPNA4   6397
Cards
Entrez_Gene (NCBI)KPNA4  3840  karyopherin subunit alpha 4
AliasesIPOA3; QIP1; SRP3
GeneCards (Weizmann)KPNA4
Ensembl hg19 (Hinxton)ENSG00000186432 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186432 [Gene_View]  ENSG00000186432 [Sequence]  chr3:160494995-160565588 [Contig_View]  KPNA4 [Vega]
ICGC DataPortalENSG00000186432
TCGA cBioPortalKPNA4
AceView (NCBI)KPNA4
Genatlas (Paris)KPNA4
WikiGenes3840
SOURCE (Princeton)KPNA4
Genetics Home Reference (NIH)KPNA4
Genomic and cartography
GoldenPath hg38 (UCSC)KPNA4  -     chr3:160494995-160565588 -  13q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KPNA4  -     13q14.2   [Description]    (hg19-Feb_2009)
EnsemblKPNA4 - 13q14.2 [CytoView hg19]  KPNA4 - 13q14.2 [CytoView hg38]
Mapping of homologs : NCBIKPNA4 [Mapview hg19]  KPNA4 [Mapview hg38]
OMIM602970   
Gene and transcription
Genbank (Entrez)AB002533 AF038199 AK021602 AK055675 AK129841
RefSeq transcript (Entrez)NM_002268
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KPNA4
Cluster EST : UnigeneHs.467866 [ NCBI ]
CGAP (NCI)Hs.467866
Alternative Splicing GalleryENSG00000186432
Gene ExpressionKPNA4 [ NCBI-GEO ]   KPNA4 [ EBI - ARRAY_EXPRESS ]   KPNA4 [ SEEK ]   KPNA4 [ MEM ]
Gene Expression Viewer (FireBrowse)KPNA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3840
GTEX Portal (Tissue expression)KPNA4
Human Protein AtlasENSG00000186432-KPNA4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00629   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00629  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00629
Splice isoforms : SwissVarO00629
PhosPhoSitePlusO00629
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Arm_3    Armadillo    Importin-a_IBB    Importin-a_IBB_sf    Importing_su_alpha   
Domain families : Pfam (Sanger)Arm (PF00514)    Arm_3 (PF16186)    IBB (PF01749)   
Domain families : Pfam (NCBI)pfam00514    pfam16186    pfam01749   
Domain families : Smart (EMBL)ARM (SM00185)  
Conserved Domain (NCBI)KPNA4
DMDM Disease mutations3840
Blocks (Seattle)KPNA4
PDB (SRS)4UAE    5TBK    5XZX   
PDB (PDBSum)4UAE    5TBK    5XZX   
PDB (IMB)4UAE    5TBK    5XZX   
PDB (RSDB)4UAE    5TBK    5XZX   
Structural Biology KnowledgeBase4UAE    5TBK    5XZX   
SCOP (Structural Classification of Proteins)4UAE    5TBK    5XZX   
CATH (Classification of proteins structures)4UAE    5TBK    5XZX   
SuperfamilyO00629
Human Protein Atlas [tissue]ENSG00000186432-KPNA4 [tissue]
Peptide AtlasO00629
HPRD04275
IPIIPI00012578   IPI00386807   IPI00386960   IPI00946316   
Protein Interaction databases
DIP (DOE-UCLA)O00629
IntAct (EBI)O00629
FunCoupENSG00000186432
BioGRIDKPNA4
STRING (EMBL)KPNA4
ZODIACKPNA4
Ontologies - Pathways
QuickGOO00629
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytosol  NLS-bearing protein import into nucleus  modulation by virus of host process  nuclear membrane  response to hydrogen peroxide  nuclear import signal receptor activity  nuclear import signal receptor activity  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytosol  NLS-bearing protein import into nucleus  modulation by virus of host process  nuclear membrane  response to hydrogen peroxide  nuclear import signal receptor activity  nuclear import signal receptor activity  
NDEx NetworkKPNA4
Atlas of Cancer Signalling NetworkKPNA4
Wikipedia pathwaysKPNA4
Orthology - Evolution
OrthoDB3840
GeneTree (enSembl)ENSG00000186432
Phylogenetic Trees/Animal Genes : TreeFamKPNA4
HOVERGENO00629
HOGENOMO00629
Homologs : HomoloGeneKPNA4
Homology/Alignments : Family Browser (UCSC)KPNA4
Gene fusions - Rearrangements
Fusion : MitelmanKPNA4/PALM2 [3q25.33/9q31.3]  
Fusion : QuiverKPNA4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKPNA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KPNA4
dbVarKPNA4
ClinVarKPNA4
1000_GenomesKPNA4 
Exome Variant ServerKPNA4
ExAC (Exome Aggregation Consortium)ENSG00000186432
GNOMAD BrowserENSG00000186432
Varsome BrowserKPNA4
Genetic variants : HAPMAP3840
Genomic Variants (DGV)KPNA4 [DGVbeta]
DECIPHERKPNA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKPNA4 
Mutations
ICGC Data PortalKPNA4 
TCGA Data PortalKPNA4 
Broad Tumor PortalKPNA4
OASIS PortalKPNA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKPNA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKPNA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KPNA4
DgiDB (Drug Gene Interaction Database)KPNA4
DoCM (Curated mutations)KPNA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KPNA4 (select a term)
intoGenKPNA4
Cancer3DKPNA4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602970   
Orphanet
DisGeNETKPNA4
MedgenKPNA4
Genetic Testing Registry KPNA4
NextProtO00629 [Medical]
TSGene3840
GENETestsKPNA4
Target ValidationKPNA4
Huge Navigator KPNA4 [HugePedia]
snp3D : Map Gene to Disease3840
BioCentury BCIQKPNA4
ClinGenKPNA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3840
Chemical/Pharm GKB GenePA30188
Clinical trialKPNA4
Miscellaneous
canSAR (ICR)KPNA4 (select the gene name)
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKPNA4
EVEXKPNA4
GoPubMedKPNA4
iHOPKPNA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Aug 16 11:10:16 CEST 2018

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